Patents by Inventor Long Pan

Long Pan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20260125667
    Abstract: Provided are an enzyme immobilization carrier and a preparation method therefor, an immobilized enzyme and a preparation method therefor, and use thereof. The enzyme immobilization carrier comprises a resin matrix and a divinyl sulfone group modified on the resin matrix by means of a covalent bond. In order to realize the directed immobilization of an enzyme, the divinyl sulfone group is loaded on the resin matrix by means of the covalent bond. In a subsequent enzyme immobilization reaction, by using specific binding of the divinyl sulfone group to a histidine tag, the divinyl sulfone group in the enzyme immobilization carrier is connected to a specific amino acid residue in an enzyme molecule by means of a covalent bond, without reacting with an active group in the enzyme molecule, thereby effectively avoiding excessive influence of the enzyme immobilization carrier on enzyme conformation, and thus retaining a high catalytic activity of the enzyme.
    Type: Application
    Filed: May 19, 2023
    Publication date: May 7, 2026
    Inventors: Hao HONG, Gage JAMES, Yi XIAO, Long PAN, Liteng MA, Yuxia CUI, Bingyang HOU
  • Publication number: 20260109726
    Abstract: An immobilized 4,5-dicyanoimidazole, and a preparation method and application thereof. The immobilized 4,5-dicyanoimidazole is obtained through a free radical copolymerization reaction of a first comonomer, a second comonomer, and a third comonomer. The first comonomer is divinyl benzene or ethylene glycol dimethacrylate. The second comonomer is styrene or methyl methacrylate.
    Type: Application
    Filed: March 24, 2023
    Publication date: April 23, 2026
    Inventors: Hao HONG, Gage JAMES, Yi XIAO, Long PAN, Yuchen SUN, Hangfei ZHANG
  • Publication number: 20260083650
    Abstract: The present disclosure relates to stabilized oral care compositions comprising amino acids and traditionally incompatible flavor components. Methods of making and use are further provided.
    Type: Application
    Filed: December 1, 2025
    Publication date: March 26, 2026
    Applicant: Colgate-Palmolive Company
    Inventors: Zhigang HAO, Erin LASKOWSKI, Victoria YEUNG, Mania BANKOVA, Long PAN, Yun XU, Peng YAN, Fusong SUN, Zheng YANG, Chi-Yuan CHENG, Tatiana BRINZARI
  • Patent number: 12486091
    Abstract: A coated packaging article may include a packaging article and a coating. The packaging article may include a body having an interior surface, and the coating may be disposed over at least one portion of the interior surface of the body. The coating may include an edible oil and a surfactant. The coating may be in a liquid state on the interior surface inside the packaging article. The coating may be in direct contact with the at least one portion of the interior surface of the body.
    Type: Grant
    Filed: December 15, 2022
    Date of Patent: December 2, 2025
    Assignee: Colgate-Palmolive Company
    Inventors: Zhigang Hao, Long Pan, Shiyou Xu
  • Patent number: 12485073
    Abstract: A stabilized oral care composition comprises amino acids and traditionally incompatible flavor components. Methods of making and use are further provided.
    Type: Grant
    Filed: April 25, 2019
    Date of Patent: December 2, 2025
    Assignee: Colgate-Palmolive Company
    Inventors: Zhigang Hao, Erin Laskowski, Victoria Yeung, Mania Bankova, Long Pan, Yun Xu, Peng Yan, Fusong Sun, Zheng Yang, Chi-Yuan Cheng, Tatiana Brinzari
  • Publication number: 20250236861
    Abstract: Provided are an enzyme immobilization carrier and a preparation method therefor, and an immobilized enzyme and a preparation method therefor. The enzyme immobilization carrier includes a resin ball matrix, an —N(CH2OOH)2 group linked on the resin ball matrix by means of a chemical bond, and a metal ion adsorbed on the —N(CH2OOH)2 group in a chelating manner through coordination. The resin ball matrix is an amino-type methacrylic resin and/or an epoxy-type methacrylic resin, and the resin ball matrix has a particle size of 200-700 ?m. Therefore, the problems in the related art that an enzyme immobilization carrier is relatively poor in enzyme compatibility and poor in immobilization effect, and an immobilized enzyme is relatively poor in activity, and relatively poor in stability during repeated use are solved.
    Type: Application
    Filed: November 11, 2019
    Publication date: July 24, 2025
    Inventors: Hao Hong, Gage James, Yi Xiao, Na Zhang, Williams Vyasa, Jiadong Zhao, Long Pan, Liteng Ma, Yuxia Cui
  • Publication number: 20250170565
    Abstract: Provided are a catalyst loaded with a TEMPO-type compound, and a preparation method and use thereof. The catalyst loaded with the TEMPO-type compound uses a polymer resin as a carrier, and the polymer resin is a polystyrene resin containing a chloromethyl or bromomethyl, herein the content of the chloromethyl or bromomethyl in the polymer resin is 0.5-5.0 mmol g?1.
    Type: Application
    Filed: March 2, 2022
    Publication date: May 29, 2025
    Inventors: Hao HONG, Gage JAMES, Yi XIAO, Long PAN, Yuchen SUN, Liteng MA, Hangfei ZHANG, Bingyang HOU
  • Patent number: 12264706
    Abstract: The present invention relates to a flow control method for a high-accuracy and high-stiffness hydrostatic device, comprising: a main body and an auxiliary body; the upper surface of the main body forms a first flow channel, and a lug boss is formed on the first flow channel; the upper surface of the main body forms a second flow channel; the middle of the main body is concave down to form a pressure stabilizing cavity; the end of the first flow channel is provided with first throttling holes; the second flow channel is provided with a main oil hole; the first flow channel is provided with an oil distribution channel; the lug boss is provided with a second throttling hole; a bump matched with a bearing platform is formed on the bottom of the auxiliary body; a film sheet is arranged between the bump and the bearing platform; and the surface of the bump is provided with a groove.
    Type: Grant
    Filed: April 2, 2022
    Date of Patent: April 1, 2025
    Assignee: Haixi (Fujian) Institute, China Academy of Machinery Science&Technology Group
    Inventors: Wenzhi Liu, Chao Jiang, Hong Chen, Long Pan, Hengfeng Zhu, Fuhua Yu, Hongrong Lin, Xiufang Zheng, Jiajing Lin, Yuan Gao
  • Publication number: 20250075199
    Abstract: Provided are an immobilized enzyme and an application thereof in continuous production. The immobilized enzyme is a Polyethyleneimine (PEI)-modified immobilized enzyme, and includes: an enzyme, which includes Amine Dehydrogenase (AmDH) and/or Formate Dehydrogenase (FDH); and a carrier, which is a cyanuric chloride-activated amino carrier. The problem in the prior art of poor performance of an immobilized enzyme is solved, the catalytic activity and reusability of the immobilized enzyme are improved, and the immobilized enzyme is suitable for the field of enzyme immobilization.
    Type: Application
    Filed: February 14, 2022
    Publication date: March 6, 2025
    Inventors: Hao Hong, Gage James, Yi Xiao, Na Zhang, Long Pan, Liteng Ma, Yuxia Cui, Yanyan Gao
  • Publication number: 20250064697
    Abstract: Described herein are—inter alia—complexes comprising a curcuminoid; and an anionic surfactant. Methods of making and using same are also described.
    Type: Application
    Filed: November 13, 2024
    Publication date: February 27, 2025
    Applicant: Colgate-Palmolive Company
    Inventors: Payal ARORA, Harsh Mahendra TRIVEDI, Zhigang HAO, Paul THOMSON, Manish MANDHARE, Yu WANG, Chi-Yuan CHENG, Long PAN
  • Patent number: 12161743
    Abstract: The present disclosure provides a chlorhexidine-cyclamate complex having a formula [C22H32Cl2N10][C6H12NO3S]2 having antibacterial and antiplaque properties, together with oral care compositions comprising the complex, and methods of making and using these complexes and compositions.
    Type: Grant
    Filed: March 15, 2022
    Date of Patent: December 10, 2024
    Assignee: Colgate-Palmolive Company
    Inventors: Zhigang Hao, Chi-Yuan Cheng, Long Pan, Ravi Subramanyam
  • Publication number: 20240384757
    Abstract: The present invention relates to a flow control method for a high-accuracy and high-stiffness hydrostatic device, comprising: a main body and an auxiliary body; the upper surface of the main body forms a first flow channel, and a lug boss is formed on the first flow channel; the upper surface of the main body forms a second flow channel; the middle of the main body is concave down to form a pressure stabilizing cavity; the end of the first flow channel is provided with first throttling holes; the second flow channel is provided with a main oil hole; the first flow channel is provided with an oil distribution channel; the lug boss is provided with a second throttling hole; a bump matched with a bearing platform is formed on the bottom of the auxiliary body; a film sheet is arranged between the bump and the bearing platform; and the surface of the bump is provided with a groove.
    Type: Application
    Filed: April 2, 2022
    Publication date: November 21, 2024
    Applicant: Haixi (Fujian) Institute,China Academy of Machinery Science&Technology Group
    Inventors: WENZHI LIU, CHAO JIANG, HONG CHEN, LONG PAN, HENGFENG ZHU, FUHUA YU, HONGRONG LIN, XIUFANG ZHENG, JIAJING LIN, YUAN GAO
  • Patent number: 12109285
    Abstract: An oral care composition having a soluble zinc polyphosphate complex made by combining ingredients including an inorganic zinc salt, and a plurality of long chain polyphosphates having 6 or more phosphate polymer units, the relative amount of inorganic zinc salt and long chain polyphosphates providing a phosphorus to zinc mole ratio of at least 6:1. Further provided is a method of treating a subject suffering from dentinal sensitivity applying the oral care composition to the teeth and gums of the subject.
    Type: Grant
    Filed: December 26, 2014
    Date of Patent: October 8, 2024
    Assignee: Colgate-Palmolive Company
    Inventors: Baohua Qiao, Long Pan, Gregory Szewczyk, Ravi Subramanyam
  • Publication number: 20240325440
    Abstract: A soluble zinc polyphosphate complex made by combining ingredients which include an inorganic zinc salt and a plurality of long chain polyphosphates having 6 or more phosphate polymer units, the relative amount of inorganic zinc salt and long chain polyphosphates providing a phosphorus to zinc mole ratio of at least 6:1. Further provided is a method of making this soluble zinc polyphosphate.
    Type: Application
    Filed: June 10, 2024
    Publication date: October 3, 2024
    Applicant: Colgate-Palmolive Company
    Inventors: Baohua Qiao, Long Pan, Gregory Szewczyk, Ravi Subramanyam
  • Publication number: 20240294320
    Abstract: A bottle with a retractable straw comprises a bottle body, a bottle cap and a straw. The bottle cap comprises a bottom cap, a rotating sleeve and a top cap. The bottom cap covers a mouth of the bottle body and is provided with a first sleeve tube. A spiral slideway is arranged on an inner wall of the first sleeve tube. The rotating sleeve is arranged on an upper surface of the bottom cap. A second sleeve tube is arranged on the rotating sleeve. A vertical sliding groove is formed in a tube wall of the second sleeve tube. Limiting grooves in opposite directions are formed in upper and lower ends of the sliding groove and connected with the sliding groove.
    Type: Application
    Filed: May 13, 2024
    Publication date: September 5, 2024
    Inventor: Long Pan
  • Publication number: 20240199295
    Abstract: A coated packaging article may include a packaging article and a coating. The packaging article may include a body having an interior surface, and the coating may be disposed over at least one portion of the interior surface of the body. The coating may include an edible oil and a surfactant. The coating may be in a liquid state on the interior surface inside the packaging article. The coating may be in direct contact with the at least one portion of the interior surface of the body.
    Type: Application
    Filed: December 15, 2022
    Publication date: June 20, 2024
    Applicant: Colgate-Palmolive Company
    Inventors: Zhigang HAO, Long Pan, Shiyou Xu
  • Publication number: 20240199538
    Abstract: This application relates to a novel chlorhexidine lauryl sulfate salt, which provides enhanced chlorhexidine stability and enhanced anti-bacterial activity, and to formulations and methods utilizing the novel salt.
    Type: Application
    Filed: December 6, 2023
    Publication date: June 20, 2024
    Inventors: Viktor DUBOVOY, Dailin Chen, Zhigang Hao, Xing He, Long Pan, Chi-Yuan Cheng, Yu Wang, Jake Salerno, Tatiana Brinzari
  • Patent number: 12012338
    Abstract: Described herein are zirconium oxychloride clusters comprising zirconium oxychloride and a basic amino acid. Oral care compositions comprising the same; and methods of making and using the same are also described.
    Type: Grant
    Filed: December 11, 2018
    Date of Patent: June 18, 2024
    Assignee: Colgate-Palmolive Company
    Inventors: Viktor Dubovoy, Irene Petrou, Long Pan
  • Publication number: 20240191008
    Abstract: Provided is an amination method for a polystyrene-type resin, and a method for immobilizing an enzyme using an aminated polystyrene-type resin. The amination method includes: in a solvent, a catalyst is used to catalyze a polystyrene-type resin and an enamine salt to perform a Friedel-Crafts alkylation reaction, to obtain an aminated polystyrene-type resin, herein the catalyst is a Lewis acid catalyst. By means of the Friedel-Crafts alkylation reaction, the enamine salt is grafted onto the polystyrene-type resin, and the polystyrene-type resin is aminated. The conditions of the Friedel-Crafts alkylation reaction are easy to control, the post-treatment process is simple, and it is only necessary to remove the catalyst and the unreacted enamine salt by washing. Therefore, the above amination method in the present application has few steps and is simple and easy to implement. Meanwhile, the amination method further avoids the use of a noble metal catalyst, thereby reducing production cost.
    Type: Application
    Filed: May 10, 2021
    Publication date: June 13, 2024
    Inventors: Hao HONG, Yi XIAO, Na ZHANG, Han LIN, Long PAN, Williams VYASA, Liteng MA, Yuxia CUI, Yanyan GAO
  • Patent number: 12005076
    Abstract: A soluble zinc polyphosphate complex made by combining ingredients which include an inorganic zinc salt and a plurality of long chain polyphosphates having 6 or more phosphate polymer units, the relative amount of inorganic zinc salt and long chain polyphosphates providing a phosphorus to zinc mole ratio of at least 6:1. Further provided is a method of making this soluble zinc polyphosphate.
    Type: Grant
    Filed: December 26, 2014
    Date of Patent: June 11, 2024
    Assignee: Colgate-Palmolive Company
    Inventors: Baohua Qiao, Long Pan, Gregory Szewczyk, Ravi Subramanyam