Abstract: Provided are compounds of Formula I: and pharmaceutically acceptable salts and compositions thereof, which are useful for treating cancers and related conditions.

Abstract: Provided are PROTACs comprised of a targeting moiety designed to bind KRAS (G12D) linked to a degrader-directing moiety designed to bind an E3 ubiquitin-ligase. Pharmaceutical compositions comprising the disclosed PROTACs and their use in treating cancer and related conditions are also provided.

Abstract: Disclosed is a grease-isolating structure for storing a circuit board, the structure being disposed in an outer tube of a solar actuator, in the outer tube being further provided the circuit board, a through-hole running axially through the outer tube being provided for the outer tube, wherein a cavity for storing the circuit board is provided on a wall of the outer tube, the cavity and the through-hole being isolated from each other. Further disclosed is a solar actuator in which the circuit board storage structure is provided.

Abstract: Provided are compounds of Formula (I) and pharmaceutically acceptable salts and compositions thereof, which are useful for treating cancers and related conditions.

Abstract: The present disclosure discloses a strain of Acidomyces acidothermus and its application in leaching copper-containing pollutants from waste circuit boards, belonging to the technical field of bio-leaching. According to the present disclosure, a strain of A. acidothermus is separated from the sludge of a Changzhou sewage treatment plant; and the strain can normally grow under an acidic condition, and copper contained in a system can be leached out in a form of copper ions by adding the strain into waste or pollutants containing heavy metal copper, so that the metal copper in the waste or pollutants is effectively treated. The treatment process is simple, the requirements for the environment and the technology are low, and the treated waste liquid does not contain high-concentration chemical reagents, which facilitates subsequent waste liquid treatment; and therefore, the A. acidothermus is suitable for industrial application.

Abstract: Provided are compounds of Formula: H-L-T and pharmaceutically acceptable salts and compositions thereof, which are useful for treating cancers and related conditions.

Abstract: Provided are compounds of Formula (I) and pharmaceutically acceptable salts and compositions thereof, which are useful for treating cancers and related conditions.

Abstract: An optical imaging lens includes six lens elements positioned sequentially from an object side to an image side along an optical axis. The image-side surface of the first lens element has a concave portion in a vicinity of the periphery of the first lens element and the object-side surface of the sixth lens element has a convex portion in a vicinity of the periphery of the sixth lens element. Gaa is a sum of all five air gaps from the first lens element to the sixth lens element along the optical axis, T5 is a central thickness of the fifth lens element along the optical axis, and Gaa and T5 satisfy the equation Gaa/T5?3.85.

Abstract: An optical imaging lens includes first, second, third, fourth, fifth, and sixth lens elements, each having an object-side surface facing toward an object side and an image-side surface facing toward an image side. The image-side surface of the first lens element includes a concave portion in a vicinity of a periphery of the first lens element. The optical imaging lens as a whole has only the six lens elements having refractive power. The ratio between the f-number of the optical imaging lens and thicknesses of the lens elements satisfies certain relations.

Abstract: Disclosed is a grease-isolating structure for storing a circuit board, the structure being disposed in an outer tube of a solar actuator, in the outer tube being further provided the circuit board, a through-hole running axially through the outer tube being provided for the outer tube, wherein a cavity for storing the circuit board is provided on a wall of the outer tube, the cavity and the through-hole being isolated from each other. Further disclosed is a solar actuator in which the circuit board storage structure is provided.

Abstract: Provided herein are methods and compositions for targeted protein degradation. In one aspect, a protein degradation chimera is provided, comprising: a first moiety that is capable of binding to a chaperone complex component; a second moiety that is capable of binding to a target protein or proteins, wherein the target protein (s) is targeted for degradation; and a tether configured to covalently couple the first moiety and the second moiety.

Abstract: Provided are compounds of Formula I: (I) and pharmaceutically acceptable salts and compositions thereof, which are useful for treating cancers and related conditions.

Abstract: An optical imaging lens includes first, second, third, fourth, fifth, and sixth lens elements, each having an object-side surface facing toward an object side and an image-side surface facing toward an image side. The image-side surface of the first lens element includes a concave portion in a vicinity of a periphery of the first lens element. The optical imaging lens as a whole has only the six lens elements having refractive power. The ratio between the f-number of the optical imaging lens and thicknesses of the lens elements satisfies certain relations.

Abstract: An optical imaging lens includes first, second, third, fourth, fifth, and sixth lens elements, each having an object-side surface facing toward an object side and an image-side surface facing toward an image side. The image-side surface of the first lens element includes a concave portion in a vicinity of the optical axis and a concave portion in a vicinity of a periphery of the first lens element. The image-side surface of the second lens element includes a convex portion in a vicinity of the optical axis. The image-side surface of the third lens element includes a concave portion in a vicinity of a periphery of the third lens element. The object-side surface of the fourth lens element includes a concave portion in a vicinity of the optical axis. The optical imaging lens as a whole has only the six lens elements having refractive power.

Abstract: A standalone and virtual proactive services (vPAS) implementation is described. The vPAS is entirely self-contained, encrypted, and can be hosted within the customer's network. Furthermore, data collected by the vPAS can be analyzed without the data leaving the customer's firewall, thereby providing additional assurance to the network operator's data security and privacy. Moreover, the solution is developed based on an architecture that enables the platform to run in a variety of computing environments, including cloud-based environments. The vPAS system addresses data security and privacy concerns, enables different budgeting options, enables in-line predictive analysis, provides flexible delivery options, and increases the performance of preemptive services.

Abstract: An optical imaging lens includes first, second, third, fourth, fifth, and sixth lens elements, each having an object-side surface facing toward an object side and an image-side surface facing toward an image side. The image-side surface of the first lens element includes a concave portion in a vicinity of the optical axis and a concave portion in a vicinity of a periphery of the first lens element. The image-side surface of the second lens element includes a convex portion in a vicinity of the optical axis. The image-side surface of the third lens element includes a concave portion in a vicinity of a periphery of the third lens element. The object-side surface of the fourth lens element includes a concave portion in a vicinity of the optical axis. The optical imaging lens as a whole has only the six lens elements having refractive power.

Abstract: An optical imaging lens includes first, second, third, fourth, fifth, and sixth lens elements, each having an object-side surface facing toward an object side and an image-side surface facing toward an image side. The image-side surface of the first lens element comprises a concave portion in a vicinity of a periphery of the first lens element and the image-side surface of the second lens element comprises a convex portion in a vicinity of the optical axis. The fourth lens element has positive refractive power. The image-side surface of the sixth lens element comprises a concave portion in a vicinity of the optical axis and the optical imaging lens as a whole has only the six lens elements having refractive power.

Abstract: A standalone and virtual proactive services (vPAS) implementation is described. The vPAS is entirely self-contained, encrypted, and can be hosted within the customer's network. Furthermore, data collected by the vPAS can be analyzed without the data leaving the customer's firewall, thereby providing additional assurance to the network operator's data security and privacy. Moreover, the solution is developed based on an architecture that enables the platform to run in a variety of computing environments, including cloud-based environments. The vPAS system addresses data security and privacy concerns, enables different budgeting options, enables in-line predictive analysis, provides flexible delivery options, and increases the performance of preemptive services.

Abstract: the An optical imaging lens includes four lens elements positioned in order from object side to the image side of the optical imaging lens. Through controlling the convex or concave shape of the surfaces of lens elements, the refracting power of lens elements, the thickness of the at least one lens element, one or more air gaps between lens elements along the optical axis, and a half field of view HFOV of the optical imaging lens, an embodiment satisfies the relation: 4.21?T3/(G12×tan(HFOV))?7.55, for which T3 is the thickness of the third lens element and G12 is the air gap between the first lens element and the second lens element. The optical imaging lens provided by embodiments of the present invention has better optical characteristics and a reduced total length in comparison to conventional lenses.