Patents by Inventor Longchuan Huang

Longchuan Huang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cycloalkyl-dione derivatives and methods of their use
    Patent number: 8530520
    Abstract: The present invention is directed to carboxylic acid-containing pharmaceutical compounds where the carboxylic acid moieties have been substituted with cycloalkyl-dione derivatives, as well as tautomers and pharmaceutically acceptable salt forms thereof. These bioisosteric replacements improve the compound's ability to effectively cross the blood brain barrier and result in improved pharmacokinetic, toxicological, and/or safety profiles.
    Type: Grant
    Filed: June 6, 2012
    Date of Patent: September 10, 2013
    Assignee: The Trustees Of The University Of Pennsylvania
    Inventors: Onur Atasoylu, Carlo Ballatore, Kurt R. Brunden, Longchuan Huang, Donna M. Huryn, Michael James, Virginia M. Y. Lee, Francesco Piscitelli, Amos B. Smith, III, James Soper, John Q. Trojanowski