Patents by Inventor Longfei Xie

Longfei Xie has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Tubulysin analogs and methods for their preparation
    Patent number: 10723727
    Abstract: The present invention is directed to novel cytotoxic tubulysin analogs and derivatives, to antibody drug conjugates thereof, and to methods for using the same to treat medical conditions including cancer.
    Type: Grant
    Filed: January 27, 2017
    Date of Patent: July 28, 2020
    Assignee: Pfizer Inc.
    Inventors: Chakrapani Subramanyam, Lawrence N. Tumey, Longfei Xie, Carolyn Leverett, Beth C. Vetelino, Sai Chetan K. Sukuru, Sarah Hudson, Venkata Ramana Doppalapudi, Abhijit S. Bhat
  • TUBULYSIN ANALOGS AND METHODS FOR THEIR PREPARATION
    Publication number: 20180362519
    Abstract: The present invention is directed to novel cytotoxic tubulysin analogs and derivatives, to antibody drug conjugates thereof, and to methods for using the same to treat medical conditions including cancer.
    Type: Application
    Filed: January 27, 2017
    Publication date: December 20, 2018
    Applicants: PFIZER INC., CovX Technologies Ireland Limited
    Inventors: Chakrapani SUBRAMANYAM, Lawrence N. TUMEY, Longfei XIE, Carolyn LEVERETT, Beth C. VETELINO, Sai Chetan K. SUKURU, Sarah HUDSON, Venkata Ramana DOPPALAPUDI, Abhijit S. BHAT
  • Coumarin-amide derivatives and its preparation, said drug composition and its use
    Patent number: 8338401
    Abstract: The present invention relates to novel coumarin derivatives, their carboxamides, pharmaceutical compositions containing them and their uses as drugs for kidney protection, treating drugs of hypertension, cardio-cerebrovascular diseases, non-insulin dependent diabetes, tumor, pre-cancerous lesion, and edemas.
    Type: Grant
    Filed: December 5, 2003
    Date of Patent: December 25, 2012
    Assignee: Institute of Materia Medica Chinese Academy of Medical Sciences
    Inventors: Shiping Xu, Xiaoguang Chen, Song Xu, Lanmin Li, Longfei Xie, Hongyan Li, Yan Li, Guifang Cheng
  • TETRAHYDROFURANYL SULFONAMIDES AND PHARMACEUTICAL COMPOSITIONS THEREOF
    Publication number: 20110178165
    Abstract: The invention is directed to a class of compounds, including the pharmaceutically acceptable salts of the compounds, having the structure of formula (I): as defined in the specification. The invention is also directed to compositions containing the compounds of formula (I). They are useful in the treatment of CNS disorders.
    Type: Application
    Filed: September 25, 2009
    Publication date: July 21, 2011
    Inventors: Kimberly Gail Estep, Christopher John O'Donnell, Longfei Xie
  • Oxopiperdinyl And Pyranyl Sulfonamides and Pharmaceutical Compositions Thereof
    Publication number: 20110172297
    Abstract: The invention is directed to a class of compounds, including the pharmaceutically acceptable salts of the compounds, having the structure of Formula (I): as defined in the specification. The invention is also directed to compositions containing the compounds of Formula (I) as AMPA modulators.
    Type: Application
    Filed: September 18, 2009
    Publication date: July 14, 2011
    Inventors: Kimberly Gail Estep, Antone F.J. Fliri, Randall James Gallaschun, Christopher John O'Donnell, Nandini Chaturbhai Patel, Jacob Bradley Schwarz, Longfei Xie