Patents by Inventor Loning Fu

Loning Fu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Uses of circadian gene mPer2
    Publication number: 20040161408
    Abstract: Data presented herein provide a molecular mechanism for circadian gene mPer2 in DNA damage response and tumor suppression in vivo. Mice deficient in mPer2 gene display neoplastic phenotypes. These mice are deficient in p53-mediated apoptosis in thymocytes and have increased tumor occurrences after &ggr;-radiation. Core circadian genes are induced by &ggr;-radiation in wild-type mice but not in mPer2 mutant mice. Temporal expression of genes involved in cell cycle regulation and tumor suppression, such as c-Myc, Cyclin D1, Cyclin A, Mdm-2 and Gadd45&agr; is dependent on mPER2 in vivo.
    Type: Application
    Filed: July 25, 2003
    Publication date: August 19, 2004
    Inventors: Cheng-Chi Lee, Loning Fu, Peng Huang, Jinsong Liu