Patents by Inventor Loran Marie Killar

Loran Marie Killar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Transgenic animal model for degenerative diseases of cartilage
    Patent number: 7453021
    Abstract: The present invention provides animal model systems for cartilage-degenerative disease, which comprise transgenic animals which can express recombinant matrix-degrading enzymes (MDEs), particularly matrix metalloproteinases (MMPs), in a temporally and spatially regulated manner. The invention also provides methods for producing phenotypic indicators of cartilage-degenerative disease in a mammal and methods for determining the potential of a composition to counteract cartilage-degenerative disease. The invention also provides isolated nucleic acids encoding proMMP polypeptides that exhibit constitutive enzymatic activity and isolated proMMP polypeptides.
    Type: Grant
    Filed: February 27, 2003
    Date of Patent: November 18, 2008
    Assignee: Wyeth
    Inventors: Lisa Ann Neuhold, Loran Marie Killar
  • Transgenic animal model for degenerative diseases of cartilage
    Patent number: 7332646
    Abstract: The present invention provides animal model systems for cartilage-degenerative disease, which comprise transgenic animals which can express recombinant matrix-degrading enzymes (MDEs), particularly matrix metalloproteinases (MMPs), in a temporally and spatially regulated manner. The invention also provides methods for producing phenotypic indicators of cartilage-degenerative disease in a mammal and methods for determining the potential of a composition to counteract cartilage-degenerative disease. The invention also provides isolated nucleic acids encoding proMMP polypeptides that exhibit constitutive enzymatic activity and isolated proMMP polypeptides.
    Type: Grant
    Filed: November 20, 2000
    Date of Patent: February 19, 2008
    Assignee: Wyeth
    Inventors: Lisa Ann Neuhold, Loran Marie Killar
  • Transgenic mouse model for degeneration of type II collagen in joints
    Patent number: 6613958
    Abstract: The present invention provides animal model systems for cartilage-degenerative disease, which comprise transgenic animals which can express recombinant matrix-degrading enzymes (MDEs), particularly matrix metalloproteinases (MMPs), in a temporally and spatially regulated manner. The invention also provides methods for producing phenotypic indicators of cartilage-degenerative disease in a mammal and methods for determining the potential of a composition to counteract cartilage-degenerative disease. The invention also provides isolated nucleic acids encoding proMMP polypeptides that exhibit constitutive enzymatic activity and isolated proMMP polypeptides.
    Type: Grant
    Filed: December 19, 1997
    Date of Patent: September 2, 2003
    Assignee: Wyeth
    Inventors: Lisa Ann Neuhold, Loran Marie Killar
  • Transgenic animal model for degenerative diseases of cartilage
    Publication number: 20030159165
    Abstract: The present invention provides animal model systems for cartilage-degenerative disease, which comprise transgenic animals which can express recombinant matrix-degrading enzymes (MDEs), particularly matrix metalloproteinases (MMPs), in a temporally and spatially regulated manner. The invention also provides methods for producing phenotypic indicators of cartilage-degenerative disease in a mammal and methods for determining the potential of a composition to counteract cartilage-degenerative disease. The invention also provides isolated nucleic acids encoding proMMP polypeptides that exhibit constitutive enzymatic activity and isolated proMMP polypeptides.
    Type: Application
    Filed: February 27, 2003
    Publication date: August 21, 2003
    Applicant: Wyeth
    Inventors: Lisa Ann Neuhold, Loran Marie Killar