Patents by Inventor Lorelei P. Westin

Lorelei P. Westin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Anchored strand displacement amplification on an electronically addressable microchip
    Publication number: 20030219804
    Abstract: Methods and compositions of matter are provided for the strand displacement amplification of target nucleic acids of interest using primer pair sets that are anchored to electronically addressable capture sites on a microarray. The primer pair sets may be individually bound to the capture sites or may comprise a unique branched primer pair moiety. The anchored primers allow for the simultaneous multiplex capture, amplification and detection of a target nucleic acid derived from any sample source.
    Type: Application
    Filed: March 11, 2003
    Publication date: November 27, 2003
    Applicant: Nanogen, Inc.
    Inventors: Michael I. Nerenberg, Carl F. Edman, Lorelei P. Westin, Lana L. Feng, Geoffrey C. Landis, Ronald G. Sosnowski
  • Multiplex amplification and separation of nucleic acid sequences on a bioelectronic microchip using asymmetric structures
    Patent number: 6589742
    Abstract: A method for amplifying nucleic acids is provided wherein detection of amplified species is enhanced by the use of asymmetric amplification. Such amplification is made asymmetric by using divergent ratios of amplification primers or by using non-extending and/or non-cleavable amplification primers. Detection of the amplicons is improved because maintenance of single stranded species of amplicons during amplification facilitates their direct capture by immobilized probes without having to include denaturing steps.
    Type: Grant
    Filed: September 17, 2001
    Date of Patent: July 8, 2003
    Assignee: Nanogen, Inc.
    Inventors: Carl F. Edman, Michael I. Nerenberg, Lorelei P. Westin, John J. Carrino
  • Multiplex amplification and separation of nucleic acid sequences on a bioelectronic microchip using asymmetric structures
    Publication number: 20030049629
    Abstract: A method for amplifying nucleic acids is provided wherein detection of amplified species is enhanced by the use of asymmetric amplification. Such amplification is made asymmetric by using divergent ratios of amplification primers or by using non-extending and/or non-cleavable amplification primers. Detection of the amplicons is improved because maintenance of single stranded species of amplicons during amplification facilitates their direct capture by immobilized probes without having to include denaturing steps.
    Type: Application
    Filed: September 17, 2001
    Publication date: March 13, 2003
    Inventors: Carl F. Edman, Michael I. Nerenberg, Lorelei P. Westin, John J. Carrino
  • Anchored strand displacement amplification on an electronically addressable microchip
    Patent number: 6531302
    Abstract: Methods and compositions of matter are provided for the strand displacement amplification of target nucleic acids of interest using primer pair sets that are anchored to electronically addressable capture sites on a microarray. The primer pair sets may be individually bound to the capture sites or may comprise a unique branched primer pair moiety. The anchored primers allow for the simultaneous multiplex capture, amplification and detection of a target nucleic acid derived from any sample source.
    Type: Grant
    Filed: April 12, 1999
    Date of Patent: March 11, 2003
    Assignee: Nanogen/Becton Dickinson Partnership
    Inventors: Michael I. Nerenberg, Carl F. Edman, Lorelei P. Westin, Lana L. Feng, Geoffrey C. Landis, Ronald G. Sosnowski
  • Magnetic bead-based array for genetic detection
    Publication number: 20020119470
    Abstract: This invention provides a bead array counter system that combines strand displacement amplification with magnetoresistive micro sensor chips and magnetic beads. The system allows for detection of target nucleic acids in highly dilute samples. The system further provides a means to detect specific nucleic acid sequences comprising SNPs and STRs.
    Type: Application
    Filed: October 5, 2001
    Publication date: August 29, 2002
    Inventors: Michael I. Nerenberg, Geoffrey C. Landis, Lorelei P. Westin, James P. O'Connell, Ling Wang, Ray R. Radtkey, Lana L. Feng
  • Multiplex amplification and separation of nucleic acid sequences on a bioelectronic microchip using asymmetric structures
    Patent number: 6309833
    Abstract: A method for amplifying nucleic acids is provided wherein detection of amplified species is enhanced by the use of asymmetric amplification. Such amplification is made asymmetric by using divergent ratios of amplification primers or by using non-extending and/or non-cleavable amplification primers. Detection of the amplicons is improved because maintenance of single stranded species of amplicons during amplification facilitates their direct capture by immobilized probes without having to include denaturing steps.
    Type: Grant
    Filed: April 12, 1999
    Date of Patent: October 30, 2001
    Assignee: Nanogen/Becton Dickinson Partnership
    Inventors: Carl F. Edman, Michael I. Nerenberg, Lorelei P. Westin, John J. Carrino