Patents by Inventor Loren J. Miraglia

Loren J. Miraglia has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antisense modulation of MDM2 expression
    Publication number: 20030203862
    Abstract: Compounds, compositions and methods are provided for inhibiting the expression of human mdm2. The compositions include antisense compounds targeted to nucleic acids encoding mdm2. Methods of using these oligonucleotides for inhibition of mdm2 expression and for treatment of diseases such as cancers associated with overexpression of mdm2 are provided.
    Type: Application
    Filed: December 4, 2001
    Publication date: October 30, 2003
    Inventors: Loren J. Miraglia, Pamela Nero, Mark J. Graham, Brett P. Monia, Erich Koller, Ming Yi Chiang, Muthiah Manoharan
  • Antisense oligonucleotide modulation of human MDM2 expression
    Publication number: 20020151511
    Abstract: Compounds, compositions and methods are provided for inhibiting the expression of human mdm2. The compositions comprise antisense oligonucleotides targeted to nucleic acids encoding mdm2. Methods of using these oligonucleotides for inhibition of mdm2 expression and for treatment of diseases such as cancers associated with overexpression of mdm2 are provided.
    Type: Application
    Filed: May 9, 2001
    Publication date: October 17, 2002
    Inventors: Loren J. Miraglia, Pamela Nero, Mark J. Graham, Brett P. Monia
  • Antisense modulation of human MDM2 expression
    Publication number: 20010016575
    Abstract: Compounds, compositions and methods are provided for inhibiting the expression of human mdm2. The compositions include antisense compounds targeted to nucleic acids encoding mdm2. Methods of using these oligonucleotides for inhibition of mdm2 expression and for treatment of diseases such as cancers associated with overexpression of mdm2 are provided.
    Type: Application
    Filed: January 2, 2001
    Publication date: August 23, 2001
    Inventors: Loren J. Miraglia, Pamela Nero, Mark J. Graham, Brett P. Monia, Lex M. Cowsert
  • Antisense oligonucleotide modulation of human mdm2 expression
    Patent number: 6238921
    Abstract: Compounds, compositions and methods are provided for inhibiting the expression of human mdm2. The compositions comprise antisense oligonucleotides targeted to nucleic acids encoding mdm2. Methods of using these oligonucleotides for inhibition of mdm2 expression and for treatment of diseases such as cancers associated with overexpression of mdm2 are provided.
    Type: Grant
    Filed: March 26, 1998
    Date of Patent: May 29, 2001
    Assignee: Isis Pharmaceuticals, Inc.
    Inventors: Loren J. Miraglia, Pamela Nero, Mark J. Graham, Brett P. Monia
  • Antisense modulation of human mdm2 expression
    Patent number: 6184212
    Abstract: Compounds, compositions and methods are provided for inhibiting the expression of human mdm2. The compositions include antisense compounds targeted to nucleic acids encoding mdm2. Methods of using these oligonucleotides for inhibition of mdm2 expression and for treatment of diseases such as cancers associated with overexpression of mdm2 are provided.
    Type: Grant
    Filed: March 26, 1999
    Date of Patent: February 6, 2001
    Assignee: Isis Pharmaceuticals Inc.
    Inventors: Loren J. Miraglia, Pamela Nero, Mark J. Graham, Brett P. Monia, Lex M. Cowsert