Abstract: A tubular seal includes an outflow end region and an inflow end region. The inflow end region is a portion of a polymeric web retaining a woven fabric, wherein the woven fabric has a non-linear edge defining an interface between the inflow end region and the outflow end region.

Abstract: A tubular seal includes an outflow end region and an inflow end region. The inflow end region is a portion of a polymeric web retaining a woven fabric, wherein the woven fabric has a non-linear edge defining an interface between the inflow end region and the outflow end region.

Abstract: A tubular seal includes an outflow end region and an inflow end region. The inflow end region is a portion of a polymeric web retaining a woven fabric, wherein the woven fabric has a non-linear edge defining an interface between the inflow end region and the outflow end region.

Abstract: A tubular seal includes an outflow end region and an inflow end region. The inflow end region is a portion of a polymeric web retaining a woven fabric, wherein the woven fabric has a non-linear edge defining an interface between the inflow end region and the outflow end region.

Abstract: A tubular seal includes an outflow end region and an inflow end region. The inflow end region is a portion of a polymeric web retaining a woven fabric, wherein the woven fabric has a non-linear edge defining an interface between the inflow end region and the outflow end region.

Abstract: A first catheter is dimensioned for deployment within a renal artery. A second catheter has a shaft with an outer diameter smaller than an inner diameter of the first catheter's open lumen. A gap is formed between the shaft and the first catheter when the second catheter is situated within the first catheter. The gap facilitates transport of a fluid, such as imaging contrast media, along the first catheter. An electrode arrangement at the distal end of the shaft is configured to deliver ablative energy to perivascular renal nerves, and has an outer diameter about the same size as the inner diameter of the first catheter such that a fit therebetween substantially blocks fluid flow within the gap yet provides for relative movement between the electrode arrangement and the luminal wall. A conductor extends between the proximal and distal ends of the shaft and is coupled to electrode arrangement.

Abstract: Balloon catheters and methods of making and using the same. A balloon catheter may include a catheter shaft and a balloon coupled thereto. A traction member may be coupled to the balloon catheter adjacent the balloon and may extend along a portion or all of the length of the balloon. The traction member can improve traction between the balloon and a target site.

Abstract: Stimulation energy is delivered to one or more renal artery sites in accordance with a predetermined energy delivery protocol. The stimulation energy is sufficient to elicit a physiologic response from the patient but insufficient to ablate renal nerves. Target renal artery sites that elicit a physiologic response are identified, and renal nerve tissue at or proximate the target sites is ablated.

Abstract: A first catheter is dimensioned for deployment within a renal artery. A second catheter has a shaft with an outer diameter smaller than an inner diameter of the first catheter's open lumen. A gap is formed between the shaft and the first catheter when the second catheter is situated within the first catheter. The gap facilitates transport of a fluid, such as imaging contrast media, along the first catheter. An electrode arrangement at the distal end of the shaft is configured to deliver ablative energy to perivascular renal nerves, and has an outer diameter about the same size as the inner diameter of the first catheter such that a fit therebetween substantially blocks fluid flow within the gap yet provides for relative movement between the electrode arrangement and the luminal wall. A conductor extends between the proximal and distal ends of the shaft and is coupled to electrode arrangement.

Abstract: A device for incising tissue to a pre-selected incision depth within a body conduit of a patient includes an elongated balloon catheter and at least one elongated straight blade that is mounted on the balloon. To control the incision depth, each blade has a blunt section formed with a non-incising surface and a cutting edge positioned distally to the blunt section. A proximal portion of the blade is attached to a proximal balloon section, and in operation, the balloon/blade combination is advanced into the body conduit and positioned distal to the target tissue/stenosis. The balloon is then inflated. With this inflation, the blade is inclined relative to the axis of the catheter with an increasing distance between the blade and the axis in a distal direction. The device is then withdrawn, proximally, to incise the tissue/stenosis.

Abstract: Balloon catheters and methods of making and using the same. A balloon catheter may include a catheter shaft and a balloon coupled thereto. A traction member may be coupled to the balloon catheter adjacent the balloon and may extend along a portion or all of the length of the balloon. The traction member can improve traction between the balloon and a target site.

Abstract: Balloon catheters and methods of making and using the same. A balloon catheter may include a catheter shaft and a balloon coupled thereto. A traction member may be coupled to the balloon catheter adjacent the balloon and may extend along a portion or all of the length of the balloon. The traction member can improve traction between the balloon and a target site.

Abstract: A cutting balloon catheter and method of making and using the same. The cutting balloon catheter may include a catheter shaft having a balloon coupled thereto. One or more cutting members or blades may be coupled to the balloon. The cutting members may include two or more sections that are connected via a fracturable or yielding bridge section that increases flexibility when passing through or being utilized in tortuous anatomy.