Abstract: A method of promoting and accelerating the healing of bones in animals utilizing an effective amount of a GHL-(Cu) pharmicuetical composition is disclosed. Also methods of inducing the formulation of granulation tissue in affected bones of animals using a GHL-(Cu) composition is disclosed.

Abstract: A variety of compositions suitable for use with methods for (a) reducing the formation of stomach ulcers in warm-blooded animals, (b) reducing the secretion of stomach acid in warm-blooded animals, (c) increasing the secretion of cytoprotective mucous in the stomach of warm-blooded animals, and (d) healing established stomach or intestinal ulcers in warm-blooded animals are disclosed. The compositions include glycyl-L-histidyl-L-lysine, L-lysyl-L-histidyl-glycine, L-lysyl-L-histidyl-glycine:copper(II), glycyl-L-histidyl-L-lysine:copper(II), and derivatives thereof.

Abstract: Methods are disclosed for enhancing the healing of a variety of wounds in horses. The methods generally comprise administering to the wound a therapeutically effective amount of a composition comprising GHL:Cu or a derivative thereof in combination with a physiologically acceptable carrier or diluent.

Abstract: Derivatives of GHL-Cu possessing greater resistance to proteolytic enzyme breakdown are disclosed. These derivatives can be taliored to increase their fat solubility, making them more useful in the formation of pharmaceutical creams and gels. Further, the derivatives of the present invention possess significant superoxide dismustase activity, making them useful for enhancing the wound-healing process in animals.

Abstract: Methods are disclosed for (a) enhancing the formation of a natural biological dressing composed primarily of serum proteins; (b) enhancing the reestablishment for free, full-thickness skin grafts in warm-blooded animals; (c) enhancing the establishment of split-thickness skin grafts; and (d) increasing the rate of wound closure in warm-blooded animals. The methods utilize GHL-Cu or a derivative thereof.

Abstract: A variety of compositions suitable for use within methods for (a) reducing the formation of stomach ulcers in warm-blooded animals, (b) reducing the secretion of stomach acid in warm-blooded animals, and (c) increasing the secretion of ctyoprotective mucous in the stomach of warm-blooded animals are disclosed. The compositions include glycyl-L-histidyl-L-lysine, glycyl-L-histidyl-L-lysine: copper(II), and derivatives thereof.

Abstract: A method of enhancing the wound-healing process in animals utilizing glycyl-1-histidyl-1-lysine: copper(II) (GHL-Cu) is disclosed. GHL-Cu functions as a superoxide dismutase which detoxifies tissue-damaging oxygen radicals, but does not evoke an antigenic response. A method of treating inflammatory conditions in animals and a method of reducing the traumatic effects in animals occurring subsequent to major tissue damage utilizing GHL-Cu is also disclosed.

Abstract: Derivatives of GHL-Cu possessing greater resistance to proteolytic enzyme breakdown are disclosed. These derivatives can be tailored to increse their fat solubility, making them more useful in the formation of pharmaceutical creams and gels. Further, the derivatives of the present invention possess significant superoxide dismustase activity, making them useful for enhancing the wound-healing process in animals.