Patents by Inventor Lorena de Oñate Monje

Lorena de Oñate Monje has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210139892
    Abstract: The present disclosure provides a system comprising: a) a modified RNA-binding protein (RBP) comprising: i) an RBP; and ii) one or more endosomolytic peptides (ELPs) covalently linked, directly or via a linker, to the RBP; and b) a modified cargo RNA complexed to the RBP, wherein the modified cargo RNA comprises a cargo RNA modified to include one or more RBP binding sites that are bound by the RBP present in the modified RBP. The present disclosure also provides a method of delivering a cargo RNA to a eukaryotic cell, the method comprising contacting the cell with the system of the present disclosure. The present disclosure provides methods of delivering a cargo RNA to the cytoplasm of a cell. The present disclosure provides methods of delivering a cargo RNA to the cytosol of a cell.
    Type: Application
    Filed: July 2, 2019
    Publication date: May 13, 2021
    Inventors: Ross Crawford Wilson, Colleen Amanda McGourty, Lorena de Oñate Monje