Patents by Inventor Lorena Pizzuto
Lorena Pizzuto has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20250084066Abstract: The present invention relates to the field of optical imaging. More particularly, it relates to compounds of the cyanine family with near-infrared emission characterized by improved physico-chemical and biological properties and to conjugates with biological ligands thereof. The invention also relates to the use of these compounds as optical diagnostic agents in imaging or therapy of solid tumors, to the methods for their preparation and to the compositions comprising them.Type: ApplicationFiled: November 25, 2024Publication date: March 13, 2025Applicant: BRACCO IMAGING S.P.A.Inventors: Francesco BLASI, Federica BUONSANTI, Federico CRIVELLIN, Andrea FERRARIS, Laura ORIO, Lorena PIZZUTO, Roberta NAPOLITANO, Giovanni VALBUSA
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Patent number: 12187708Abstract: The present invention relates to the field of optical imaging. More particularly, it relates to compounds of the cyanine family with near-infrared emission characterized by improved physico-chemical and biological properties and to conjugates with biological ligands thereof. The invention also relates to the use of these compounds as optical diagnostic agents in imaging or therapy of solid tumors, to the methods for their preparation and to the compositions comprising them.Type: GrantFiled: November 10, 2023Date of Patent: January 7, 2025Assignee: BRACCO IMAGING S.P.A.Inventors: Francesco Blasi, Federica Buonsanti, Federico Crivellin, Andrea Ferraris, Laura Orio, Lorena Pizzuto, Roberta Napolitano, Giovanni Valbusa
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Publication number: 20240083880Abstract: The present invention relates to the field of optical imaging. More particularly, it relates to compounds of the cyanine family with near-infrared emission characterized by improved physico-chemical and biological properties and to conjugates with biological ligands thereof. The invention also relates to the use of these compounds as optical diagnostic agents in imaging or therapy of solid tumors, to the methods for their preparation and to the compositions comprising them.Type: ApplicationFiled: November 10, 2023Publication date: March 14, 2024Applicant: BRACCO IMAGING S.P.A.Inventors: Francesco BLASI, Federica BUONSANTI, Federico CRIVELLIN, Andrea FERRARIS, Laura ORIO, Lorena PIZZUTO, Roberta NAPOLITANO, Giovanni VALBUSA
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Patent number: 11851421Abstract: The present invention relates to the field of optical imaging. More particularly, it relates to compounds of the cyanine family with near-infrared emission characterized by improved physico-chemical and biological properties and to conjugates with biological ligands thereof. The invention also relates to the use of these compounds as optical diagnostic agents in imaging or therapy of solid tumors, to the methods for their preparation and to the compositions comprising them.Type: GrantFiled: June 22, 2021Date of Patent: December 26, 2023Assignee: BRACCO IMAGING S.P.A.Inventors: Francesco Blasi, Federica Buonsanti, Federico Crivellin, Andrea Ferraris, Laura Orio, Lorena Pizzuto, Roberta Napolitano, Giovanni Valbusa
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Publication number: 20230312523Abstract: The present invention relates to the field of optical imaging. More particularly, it relates to compounds of the cyanine family with near- infrared emission characterized by improved physico-chemical and biological properties and to conjugates with biological ligands thereof. The invention also relates to the use of these compounds as optical diagnostic agents in imaging or therapy of solid tumors, to the methods for their preparation and to the compositions comprising them.Type: ApplicationFiled: June 22, 2021Publication date: October 5, 2023Applicant: BRACCO IMAGING S.P.A.Inventors: Francesco BLASI, Federica BUONSANTI, Federico CRIVELLIN, Andrea FERRARIS, Laura ORIO, Lorena PIZZUTO, Roberta NAPOLITANO, Giovanni VALBUSA
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Publication number: 20220242853Abstract: The present invention relates to the field of optical imaging More particularly, it relates to compounds of the cyanine family characterized by improved physico-chemical and biological properties and to their conjugates with biological ligands thereof. The invention also relates to the use of these compounds as optical diagnostic agents in imaging or therapy of solid tumors, to the methods for their preparation and to the compositions comprising them.Type: ApplicationFiled: May 12, 2020Publication date: August 4, 2022Applicant: BRACCO IMAGING S.P.A.Inventors: Francesco BLASI, Chiara BRIOSCHI, Federica BUONSANTI, Luigi MIRAGOLI, Roberta NAPOLITANO, Laura ORIO, Lorena PIZZUTO, Giovanni VALBUSA
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Patent number: 10870649Abstract: The application relates to a process for the synthesis of a Near Infra-Red (NIR) fluorescent probe which is a cRGD-Cy5.5 conjugate of formula (I) known as DA364 comprising an aza-bicycloalkane based cyclic peptide labelled with a Cy5.5 dye moiety and used in the guided surgery of tumors and pathologic regions.Type: GrantFiled: April 10, 2018Date of Patent: December 22, 2020Assignee: BRACCO IMAGING SPAInventors: Luciano Lattuada, Federica Buonsanti, Federico Crivellin, Fulvio Ferretti, Federico Maisano, Laura Orio, Lorena Pizzuto
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Publication number: 20200055855Abstract: The application relates to a process for the synthesis of a Near Infra-Red (NIR) fluorescent probe which is a cRGD-Cy5.5 conjugate of formula (I) known as DA364 comprising an aza-bicycloalkane based cyclic peptide labelled with a Cy5.5 dye moiety and used in the guided surgery of tumors and pathologic regions.Type: ApplicationFiled: April 10, 2018Publication date: February 20, 2020Applicant: BRACCO IMAGING SPAInventors: Luciano LATTUADA, Federica BUONSANTI, Federico CRIVELLIN, Fulvio FERRETTI, Federico MAISANO, Laura ORIO, Lorena PIZZUTO
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Patent number: 8877738Abstract: The present invention relates to monomeric and multimeric peptidic compounds which have antipathogenic, in particular antiviral or/and antibacterial activity. In a preferred aspect, the peptide compounds of the invention have an activity in respect of a broad spectrum of viruses, both DNA and RNA viruses, irrespective of whether they possess virus envelope or not. Further, the present invention refers to compositions comprising said peptidic compounds for medical use, i.e. for the treatment or prevention of pathogenic, in particular viral or/and bacterial infections.Type: GrantFiled: August 5, 2010Date of Patent: November 4, 2014Assignee: Spiderbiotech S.r.L.Inventors: Andrea Giuliani, Giovanna Pirri, Lorena Pizzuto, Santo Landolfo, Giorgio Gribaudo, David Lembo, Davide Gibellini
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Publication number: 20120121623Abstract: The present invention relates to monomeric and multimeric peptidic compounds which have antipathogenic, in particular antiviral or/and antibacterial activity. In a preferred aspect, the peptide compounds of the invention have an activity in respect of a broad spectrum of viruses, both DNA and RNA viruses, irrespective of whether they possess virus envelope or not. Further, the present invention refers to compositions comprising said peptidic compounds for medical use, i.e. for the treatment or prevention of pathogenic, in particular viral or/and bacterial infections.Type: ApplicationFiled: August 5, 2010Publication date: May 17, 2012Applicant: SPIDERBIOTCH S.r.L.Inventors: Andrea Giuliani, Giovanna Pirri, Lorena Pizzuto, Santo Landolfo, Giorgio Gribaudo, David Lembo, Davide Gibellini