Patents by Inventor Lorena S. Beese

Lorena S. Beese has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ENGINEERED POLYMERASES AND METHODS OF USING THE SAME
    Publication number: 20240052325
    Abstract: The present invention relates to fusion proteins and methods of using the same. Specifically, invention relates to fusion proteins comprising an intein and a DNA polymerase, and methods of using the same for DNA synthesis.
    Type: Application
    Filed: January 26, 2021
    Publication date: February 15, 2024
    Inventors: Lorena S. BEESE, You WANG, Yuqian SHI
  • Geranylgeranyl transferase type I (GGTase-I) structure and uses thereof
    Patent number: 7467046
    Abstract: Protein geranylgeranyl transferase type I (GGTase-I), a Ca1a2X prenyltransferase, is an essential enzyme in eukaryotes. GGTase-I catalyzes the carboxyl-terminal lipidation of over one hundred proteins, including many GTP-binding regulatory proteins (G proteins). The presently disclosed subject matter comprises a plurality of crystal structures of mammalian GGTase-I in complex with substrates and products that provide the first structural information for this enzyme, facilitating the elucidation of a generalized method of action for all protein prenyltransferases; the method includes a role in product transport. The structures reveal specificity determinants that allow classification of putative protein prenyltransferase sequences and can facilitate optimization of GGTase-I and FTase modulators.
    Type: Grant
    Filed: October 1, 2004
    Date of Patent: December 16, 2008
    Assignee: Duke University
    Inventors: Jeffrey S. Taylor, T. Scott Reid, Lorena S. Beese