Patents by Inventor Lorenz Meinel
Lorenz Meinel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20240122862Abstract: The present invention discloses a therapeutic gas release system for oral administration comprising a therapeutic gas releasing compound A, and a therapeutic gas release triggering compound B, wherein compound A and B are separated from each other by an inner septum during storage of the system, wherein compound A and B are surrounded by an outer membrane, which is a gas-permeable and water- and solid-impermeable membrane, preferably a silicone membrane, and wherein therapeutic gas release from the system is activated before oral administration by breaking the inner septum. The therapeutic gas released from the system of the present invention is suitable for the treatment of (inflammatory) diseases of the gastrointestinal tract.Type: ApplicationFiled: October 13, 2020Publication date: April 18, 2024Applicant: Julius-Maximilians-Universitaet WuerzburgInventors: Cornelius HERMANN, Lorenz MEINEL, Wolfgang SCHMEHL, Kevin POPP, Simon REILAENDER
-
Patent number: 11891352Abstract: The present invention is directed to compounds of the general formula (I) and salts thereof wherein X? is halide, pseudohalide, sulphate, benzoate, acetate, trifluoroacetate, hydroxide, saccharinate or capsaicinate; R10 is hydrogen or C1-C10-alkyl; and R1-R9 independently are hydrogen, halogen, C1-C5-alkyl, C1-C4-alkoxy, C1-C20-alkoxycarbonyl. The invention is furthermore directed to a method for the preparation of these compounds. The compounds can be used as bitter substances in medicine, pharmaceutics and/or diagnostics. They can furthermore be used for the coupling to proteins and peptides by means of forming a peptide bond between the amino-group of the compounds of the present invention and a carboxyl-group of the protein or peptide.Type: GrantFiled: February 20, 2019Date of Patent: February 6, 2024Assignee: Julius-Maximilians-UniversitaetInventors: Lorenz Meinel, Tessa Luehmann, Martina Raschig
-
Publication number: 20230112937Abstract: The present invention discloses a therapeutic system for the topic, transdermal and transcutaneous application of carbon monoxide (CO), comprising: (i) an adhesive layer, (ii) a gas-permeable and liquid- and solid-impermeable membrane, (iii) a reaction chamber comprising a CO releasing molecule A, and (iv) a gas-impermeable backing layer, wherein the transdermal therapeutic system is configured that the CO releasing molecule A can be brought into contact with a CO release triggering compound B in the reaction chamber (iii). The therapeutic system can be used for the treatment of wounds, inflammatory diseases of the skin, and inflammatory diseases of subcutaneous skin tissue, joints and tendons.Type: ApplicationFiled: March 12, 2021Publication date: April 13, 2023Applicant: Julius-Maximilians-Universitaet WuerzburgInventors: Lorenz MEINEL, Matthias RUOPP, Wolfgang SCHMEHL, Marcus Otto GUTMANN
-
Publication number: 20230091608Abstract: The present invention relates to compounds comprising denatonium linked to the C-terminus of a protease-sensitive peptide; or a salt thereof. The compounds are useful in the diagnosis of inflammatory conditions of the oral cavity.Type: ApplicationFiled: March 13, 2020Publication date: March 23, 2023Applicant: Julius-Maximilians-Universitaet WuerzburgInventors: Lorenz MEINEL, Jennifer RITZER, Tobias MIESLER
-
Patent number: 11206824Abstract: The present invention relates to a gas delivery device comprising a gas releasing molecule and a gas permeable membrane. The invention also relates to the use of the gas delivery device for delivery of gas to an extracorporeal transplant, extracorporeal cells, a brain-dead transplant donor or foodstuff and in therapy. The invention further relates to the use of a gas permeable and liquid and solid impermeable membrane to separate a gas releasing molecule and its non-gaseous degradation products from an extracorporeal transplant, extracorporeal cells, a brain-dead transplant donor or foodstuff.Type: GrantFiled: January 7, 2016Date of Patent: December 28, 2021Assignee: Julius-Maximilians-Universitaet WuerzburgInventors: Lorenz Meinel, Christoph Steiger, Christian Wunder
-
Patent number: 11110148Abstract: The present invention provides processes for producing porous silk fibroin scaffold material. The porous silk fibroin scaffold can be used for tissue engineering. The porosity of the silk fibroin scaffolds described herein can be adjusted as to mimic the gradient of densities found in natural tissue. Accordingly, methods for engineering of 3-dimensional tissue, e.g. bone and cartilage, using the silk fibroin scaffold material are also provided.Type: GrantFiled: May 17, 2018Date of Patent: September 7, 2021Assignees: Trustees of Tufts College, Massachusetts Institute of TechnologyInventors: David L. Kaplan, Rina Sears, Gordana Vunjak-Novakovic, Lorenz Meinel
-
Publication number: 20210138043Abstract: The present invention relates to compounds and their use in the treatment of lesions, in tissue regeneration and/or tissue engineering. The compounds act as substrates for enzymes having transglutaminase activity and are suitable for their immobilization and/or attached therapeutic or diagnostic molecules on extracellular matrix (ECM) or synthetic ECM-derived materials, in particular for the immobilization of myostatin inhibitors.Type: ApplicationFiled: May 17, 2019Publication date: May 13, 2021Inventors: LORENZ MEINEL, TESSA LÜHMANN, ALEXANDRA BRAUN
-
Publication number: 20210087138Abstract: The present invention is directed to compounds of the general formula (I) and salts thereof wherein X? is halide, pseudohalide, sulphate, benzoate, acetate, trifluoroacetate, hydroxide, saccharinate or capsaicinate; R10 is hydrogen or C1-C10-alkyl; and R1-R9 independently are hydrogen, halogen, C1-C5-alkyl, C1-C4-alkoxy, C1-C20-alkoxycarbonyl. The invention is furthermore directed to a method for the preparation of these compounds. The compounds can be used as bitter substances in medicine, pharmaceutics and/or diagnostics. They can furthermore be used for the coupling to proteins and peptides by means of forming a peptide bond between the amino-group of the compounds of the present invention and a carboxyl-group of the protein or peptide.Type: ApplicationFiled: February 20, 2019Publication date: March 25, 2021Applicant: Julius-Maximilians-Universitaet WuerzburgInventors: Lorenz MEINEL, Tessa LUEHMANN, Martina RASCHIG
-
Publication number: 20200397965Abstract: The present invention relates to a method for combined administration of carbon monoxide (CO) to an ex-vivo fluid and monitoring of the carbon monoxide administration, said method comprising: (i) generating CO by reacting a CO releasing molecule (CORM) with a release triggering molecule; (ii) administering CO to an ex-vivo fluid by contacting the ex-vivo fluid with the CO generated in step (i) via a gas-permeable membrane; (iii) analyzing carbon monoxide and/or a carbon monoxide marker after administering in step (ii) CO to the ex-vivo fluid by complementary monitoring techniques; (iv) adjusting the CO administration based on the analysis of the carbon monoxide or the carbon monoxide marker carried out in step (iii), if necessary. It furthermore relates to an extracorporeal circuit system for use in the method of the invention.Type: ApplicationFiled: February 7, 2019Publication date: December 24, 2020Applicants: Julius-Maximilians-Universitaet Wuerzburg, Albert-Ludwigs-Universitaet FreiburgInventors: Jakob WOLLBORN, Ulrich GOEBEL, Martin SCHICK, Cornelius HERMANN, Christian WUNDER, Lorenz MEINEL, Christoph STEIGER, Benjamin MERGET
-
Publication number: 20200283494Abstract: The present invention relates to compounds and their use in the treatment of lesions, in tissue regeneration and/or tissue engineering. The compounds act as substrates for enzymes having transglutaminase activity and are suitable for their immobilization on extracellular substrates or matrices.Type: ApplicationFiled: August 7, 2018Publication date: September 10, 2020Inventors: Alexandra BRAUN, Lorenz MEINEL, Tessa LÜHMANN
-
Patent number: 10548981Abstract: The present invention provides for novel sustained release silk-based delivery systems. The invention further provides methods for producing such formulations. In general, a silk fibroin solution is combined with a therapeutic agent to form a silk fibroin article. The article is then treated in such a way as to alter its conformation. The change in conformation increases its crystallinity or liquid crystallinity, thus controlling the release of a therapeutic agent from the formulation. This can be accomplished as single material carriers or in a layer-by-layer fashion to load different therapeutic agents or different concentrations of these agents in each layer.Type: GrantFiled: December 3, 2013Date of Patent: February 4, 2020Assignees: EIDGENOSSISCHES TECHNISCHE HOCHSCHULE (THE SWISS FEDERAL INSTITUTE OF TECHNOLOGY), TRUSTEES OF TUFTS COLLEGEInventors: David L. Kaplan, Lorenz Meinel
-
Publication number: 20190209710Abstract: The subject matter of the invention is a diagnostic sensor that can be formulated into a diagnostic chewing gum that detects relevant concentrations of influenza viruses in the oral cavity. The technical application is the initial diagnosis by those affected themselves, e.g. sore throats manifesting in them. By the detection of the influenza viruses a selective therapy of the infection is possible and employment of antibiotics that only are effective with bacterial diseases can be reduced.Type: ApplicationFiled: August 28, 2017Publication date: July 11, 2019Applicant: Julius-Maximilians-Universitaet WuerzburgInventors: Lorenz MEINEL, Tobias MIESLER, Juergen SEIBEL
-
Publication number: 20190185416Abstract: It is an object of the present invention to introduce carboxylic acid-functionalities suitable for coupling into the denatonium structure by means of simple synthesis, namely the synthesis of bitter principle derivatives based on the denatonium structure according to formula 1: For example, according to the invention, lidocaine derivatives may be reacted with carboxylated benzyl halogenides. The carboxylated denatonium derivatives of the present invention are especially applied in medicine, biology, medical engineering as well as cosmetics, the pharmaceutical, chemical, and foodstuff industry.Type: ApplicationFiled: August 11, 2017Publication date: June 20, 2019Applicant: Julius-Maximilians-Universitaet WuerzburgInventors: Ralf WYRWA, Claudia RODE, Thomas SEEMANN, Lorenz MEINEL, Jennifer RITZER, Matthias SCHNABELRAUCH
-
Publication number: 20190008923Abstract: The present invention provides processes for producing porous silk fibroin scaffold material. The porous silk fibroin scaffold can be used for tissue engineering. The porosity of the silk fibroin scaffolds described herein can be adjusted as to mimic the gradient of densities found in natural tissue. Accordingly, methods for engineering of 3-dimensional tissue, e.g. bone and cartilage, using the silk fibroin scaffold material are also provided.Type: ApplicationFiled: May 17, 2018Publication date: January 10, 2019Inventors: David L. Kaplan, Rina Sears, Gordana Vunjak-Novakovic, Lorenz Meinel
-
Publication number: 20180271086Abstract: The present invention relates to a gas delivery device comprising a gas releasing molecule and a gas permeable membrane. The invention also relates to the use of the gas delivery device for delivery of gas to an extracorporeal transplant, extracorporeal cells, a brain-dead transplant donor or foodstuff and in therapy. The invention further relates to the use of a gas permeable and liquid and solid impermeable membrane to separate a gas releasing molecule and its non-gaseous degradation products from an extracorporeal transplant, extracorporeal cells, a brain-dead transplant donor or foodstuff.Type: ApplicationFiled: January 7, 2016Publication date: September 27, 2018Applicant: Julius-Maximilians-Universitaet WuerzburgInventors: Lorenz MEINEL, Christoph STEIGER, Christian WUNDER
-
Patent number: 9993527Abstract: The present invention provides processes for producing porous silk fibroin scaffold material. The porous silk fibroin scaffold can be used for tissue engineering. The porosity of the silk fibroin scaffolds described herein can be adjusted as to mimic the gradient of densities found in natural tissue. Accordingly, methods for engineering of 3-dimensional tissue, e.g. bone and cartilage, using the silk fibroin scaffold material are also provided.Type: GrantFiled: November 19, 2012Date of Patent: June 12, 2018Assignees: TRUSTEES OF TUFTS COLLEGE, MASSACHUSETTS INSTITUTE OF TECHNOLOGYInventors: David L. Kaplan, Rina Sears, Gordana Vunjak-Novakovic, Lorenz Meinel
-
Patent number: 9669111Abstract: The document proposes a diagnostic chewing gum for identifying the presence of inflammatory tissues in the mouth, in particular in or adjacent to the mandible, the maxilla, an implant or the teeth of a user, comprising a base material or particles (3) embedded and/or attached to the base material; an element (1, 5-7), like e.g. a releasable flavor molecule, attached to the base material and/or the particles, for the generation of a change in the chewing gum directly detectable by the user; wherein the element (1, 5-7) generates the change upon direct or indirect contact with a marker (4), e.g. a proteolytic enzyme, which is released by inflammatory tissue in response to bacterial mediators.Type: GrantFiled: March 7, 2013Date of Patent: June 6, 2017Assignee: THOMMEN MEDICAL AGInventors: Matthias Schnabelrauch, Lorenz Meinel, Falko Schlottig, Ralf Wyrwa
-
Publication number: 20170151278Abstract: The present invention relates to therapeutic gas releasing systems. The system comprises compounds A and B, wherein A is a therapeutic gas releasing molecule, A and B are not in contact with each other in the therapeutic system during storage, and B enhances therapeutic gas release from A when the therapeutic system is administered to a patient.Type: ApplicationFiled: June 12, 2015Publication date: June 1, 2017Inventors: Lorenz MEINEL, Christoph STEIGER
-
Patent number: 9526803Abstract: Described herein is a diagnostic chewing gum for identifying the presence of pathogens detectable via the mouth, in particular pathogens residing in nasal, oropharyngeal, laryngeal, oesophageal, ocular and/or pulmonal tissue of a user, more particularly pathogens selected from among a virus, bacterium, protozoa, prion, fungus or a combination thereof. The inventive diagnostic chewing gum includes a base material or particles (3) embedded and/or attached to the base material and an element (1, 5-7), like e.g. a releasable flavor molecule, attached to the base material and/or the particles, for the generation of a change in the chewing gum directly detectable by the user, wherein the element (1, 5-7) generates the change upon direct or indirect contact with a marker (4) which is released by the pathogens, or, in case of a virus or prion, by the cellular structure hosting it.Type: GrantFiled: March 8, 2013Date of Patent: December 27, 2016Assignee: Julius-Maximilians-Universitaet WuerzburgInventors: Lorenz Meinel, Matthias Schnabelrauch, Falko Schlottig
-
Patent number: 9132197Abstract: The present invention provides processes for producing porous silk fibroin scaffold material. The porous silk fibroin scaffold can be used for tissue engineering. The porosity of the silk fibroin scaffolds described herein can be adjusted as to mimic the gradient of densities found in natural tissue. Accordingly, methods for engineering of 3-dimensional tissue, e.g. bone and cartilage, using the silk fibroin scaffold material are also provided.Type: GrantFiled: February 14, 2013Date of Patent: September 15, 2015Assignees: Massachusetts Institute of Technology, Trustees of Tufts CollegeInventors: David L. Kaplan, Rina Nazarov, Gordana Vunjak-Novakovic, Lorenz Meinel