Patents by Inventor Lorenza Fugazza

Lorenza Fugazza has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Stable, concentrated radionuclide complex solutions
    Publication number: 20200030465
    Abstract: The present invention relates to radionuclide complex solutions of high concentration and of high chemical stability, that allows their use as drug product for diagnostic and/or therapeutic purposes. The stability of the drug product is achieved by at least one stabilizer against radiolytic degradation. The use of two stabilizers introduced during the manufacturing process at different stages was found to be of particular advantage.
    Type: Application
    Filed: July 25, 2018
    Publication date: January 30, 2020
    Inventors: Francesco de Palo, Lorenza Fugazza, Donato Barbato, Maurizio Mariani, Daniela Chicco, Giovanni Tesoriere, Clementina Brambati
  • Stable, concentrated radionuclide complex solutions
    Publication number: 20200030464
    Abstract: The present invention relates to radionuclide complex solutions of high concentration and of high chemical stability, that allows their use as drug product for diagnostic and/or therapeutic purposes. The stability of the drug product is achieved by at least one stabilizer against radiolytic degradation. The use of two stabilizers introduced during the manufacturing process at different stages was found to be of particular advantage.
    Type: Application
    Filed: October 30, 2018
    Publication date: January 30, 2020
    Inventors: Francesco de Palo, Lorenza Fugazza, Donato Barbato, Maurizio Mariani, Daniela Chicco, Giovanni Tesoriere, Clementina Brambati
  • Process for the purification of Ga-68 from eluate deriving from Ge/Ga generators and chromatographic columns for use in said process
    Patent number: 10483008
    Abstract: Chromatography columns for the purification of eluates from 68Ge/68Ga generators comprising silica as stationary phase and purification processes that use said columns are described.
    Type: Grant
    Filed: January 28, 2016
    Date of Patent: November 19, 2019
    Assignee: Advanced Accelarator Applications International S.A.
    Inventors: Lorenza Fugazza, Maurizio Franco Mariani
  • Process for the preparation of complexes of Ga
    Patent number: 9907868
    Abstract: A process for the preparation of complexes containing 68Ga wherein a buffer formic acid/formate in the presence of compounds capable to sequester metal cations is used in the complexation reaction.
    Type: Grant
    Filed: May 24, 2016
    Date of Patent: March 6, 2018
    Assignee: Advanced Accelerator Applications International S.A.
    Inventors: Lorenza Fugazza, Maria Azzurra Filannino, Maurizio Franco Mariani
  • PROCESS FOR THE PURIFICATION OF GA-68 FROM ELUATE DERIVING FROM 68GE/68GA GENERATORS AND CHROMATOGRAPHIC COLUMNS FOR USE IN SAID PROCESS
    Publication number: 20180005719
    Abstract: Chromatography columns for the purification of eluates from 68Ge/68Ga generators comprising silica as stationary phase and purification processes that use said columns are described.
    Type: Application
    Filed: January 28, 2016
    Publication date: January 4, 2018
    Inventors: Lorenza FUGAZZA, Maurizio Franco MARIANI
  • PROCESS FOR THE PREPARATION OF COMPLEXES OF 68GA
    Publication number: 20160263259
    Abstract: A process for the preparation of complexes containing 68Ga wherein a buffer formic acid/formate in the presence of compounds capable to sequester metal cations is used in the complexation reaction.
    Type: Application
    Filed: May 24, 2016
    Publication date: September 15, 2016
    Inventors: Lorenza Fugazza, Maria Azzurra Filannino, Maurizio Franco Mariani
  • Process for the preparation of complexes of Ga
    Patent number: 9375498
    Abstract: A process for the preparation of complexes containing 68Ga wherein a buffer formic acid/formate in the presence of compounds capable to sequester metal cations is used in the complexion reaction.
    Type: Grant
    Filed: August 10, 2012
    Date of Patent: June 28, 2016
    Assignee: Advanced Accelerator Applications S.A.
    Inventors: Lorenza Fugazza, Maria Azzurra Filannino, Maurizio Franco Mariani
  • PROCESS FOR THE PREPARATION OF COMPLEXES OF 68GA
    Publication number: 20140171637
    Abstract: A process for the preparation of complexes containing 68Ga wherein a buffer formic acid/formate in the presence of compounds capable to sequester metal cations is used in the complexion reaction.
    Type: Application
    Filed: August 10, 2012
    Publication date: June 19, 2014
    Applicant: Advamced Accelerator Applications S.A.
    Inventors: Lorenza Fugazza, Maria Azzurra Filannino, Maurizio Franco Mariani
  • Process for preparing cyclohexanediacetic acid monoamide
    Patent number: 7381823
    Abstract: A new process is described for synthesising cyclohexanediacetic acid monoamide, a key compound in the synthesis of grabapentin precursors. The process of the invention is characterised by reacting cyclohexanone with cynoacetamide and immediately after, with a suitable malonic acid ester. A new intermediate (5-cyano-2,4-dioxo-3-azaspiro[5,5]undecane-1-carboxylic acid ester) is obtained which is convertible, under mild reaction conditions, into cyclohexanediacetic acid monoamide.
    Type: Grant
    Filed: March 17, 2005
    Date of Patent: June 3, 2008
    Assignee: Serichim S.R.L.
    Inventors: Bruno Danieli, Pietro Delogu, Sabrina De Rosa, Lorenza Fugazza
  • PROCESS FOR PREPARING CYCLOHEXANEDIACETIC ACID MONOAMIDE
    Publication number: 20070208175
    Abstract: A new process is described for synthesising cyclohexanediacetic acid monoamide, a key compound in the synthesis of grabapentin precursors. The process of the invention is characterised by reacting cyclohexanone with cynoacetamide and immediately after, with a suitable malonic acid ester. A new intermediate (5-cyano-2,4-dioxo-3-azaspiro[5,5]undecane-1-carboxylic acid ester) is obtained which is convertible, under mild reaction conditions, into cyclohexanediacetic acid monoamide.
    Type: Application
    Filed: March 17, 2005
    Publication date: September 6, 2007
    Inventors: Bruno Danieli, Pietro Delogu, Sabrina de Rosa, Lorenza Fugazza