Patents by Inventor Lorenzo F. Sempere

Lorenzo F. Sempere has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • VISTA Antagonist and Methods of Use
    Publication number: 20240158507
    Abstract: The present invention is directed to synergic or additive therapies comprising the administration of a VISTA antagonist and a PD-1, PD-L1 or POD-L3 antagonist; or the combination of a VISTA agonist and a -1, PD-L1 or POD-L3 agonist which combinations respectively elicit an additive or synergistic effect at promoting T cell immunity or inhibiting T cell immunity, i.e., CD4, CD8 or Th1 immunity. The agonists and antagonists may be in the same or separate compositions and may be administered together or separately administered in either order.
    Type: Application
    Filed: November 20, 2023
    Publication date: May 16, 2024
    Inventors: Randolph J. Noelle, Li Wang, Thomas Broughton, Lorenzo F. Sempere, Janet Louise Lines
  • Multi-Modal Contrast Agent For Medical Imaging
    Publication number: 20220031873
    Abstract: A nanoparticle is provided. The nanoparticle includes a magnetic core including a magnetic nanocrystal, a fluorophore coupled to the magnetic core, at least one chelating compound coupled to the magnetic core, the at least one chelating compound being a compound that chelates copper-64 (64Cu), a compound that chelates technetium-99m (99mTc), or a combination thereof, and an iodine chelator coupled to the magnetic core. Methods of making the nanoparticle and of using the nanoparticle as a multi-modal contrast agent are also provided.
    Type: Application
    Filed: July 23, 2021
    Publication date: February 3, 2022
    Applicant: Board of Trustees of Michigan State University
    Inventors: Anna V. MOORE, Lorenzo F. SEMPERE, Neil M. ROBERTSON
  • VISTA Antagonist and Methods of Use
    Publication number: 20210253708
    Abstract: The present invention is directed to synergic or additive therapies comprising the administration of a VISTA antagonist and a PD-1, PD-L1 or POD-L3 antagonist; or the combination of a VISTA agonist and a-1, PD-L1 or POD-L3 agonist which combinations respectively elicit an additive or synergistic effect at promoting T cell immunity or inhibiting T cell immunity, i.e., CD4, CD8 or Th1 immunity. The agonists and antagonists may be in the same or separate compositions and may be administered together or separately administered in either order.
    Type: Application
    Filed: November 9, 2020
    Publication date: August 19, 2021
    Inventors: Randolph J. Noelle, Li Wang, Thomas Broughton, Lorenzo F. Sempere, Janet Louise Lines
  • VISTA Agonist and Methods of Use
    Publication number: 20180237525
    Abstract: The present invention is directed to synergic or additive therapies comprising the administration of a VISTA antagonist and a PD-1, PD-L1 or POD-L3 antagonist; or the combination of a VISTA agonist and a -1, PD-L1 or POD-L3 agonist which combinations respectively elicit an additive or synergistic effect at promoting T cell immunity or inhibiting T cell immunity, i.e., CD4, CD8 or Th1 immunity. The agonists and antagonists may be in the same or separate compositions and may be administered together or separately administered in either order.
    Type: Application
    Filed: April 14, 2015
    Publication date: August 23, 2018
    Inventors: Randolph J. Noelle, Li Wang, Thomas Broughton, Lorenzo F. Sempere, Janet Louise Lines
  • VISTA Antagonist and Methods of Use
    Publication number: 20160083472
    Abstract: The present invention is directed to synergic or additive therapies comprising the administration of a VISTA antagonist and a PD-1, PD-L1 or POD-L3 antagonist; or the combination of a VISTA agonist and a -1, PD-L1 or POD-L3 agonist which combinations respectively elicit an additive or synergistic effect at promoting T cell immunity or inhibiting T cell immunity, i.e., CD4, CD8 or Th1 immunity. The agonists and antagonists may be in the same or separate compositions and may be administered together or separately administered in either order.
    Type: Application
    Filed: April 14, 2015
    Publication date: March 24, 2016
    Inventors: Randolph J. Noelle, Li Wang, Thomas Broughton, Lorenzo F. Sempere, Janet Louise Lines
  • MicroRNA biomarkers for human breast and lung cancer
    Patent number: 9056135
    Abstract: The present invention relates to novel molecular markers for diagnosis and classification of human breast cancer and lung cancer.
    Type: Grant
    Filed: May 23, 2012
    Date of Patent: June 16, 2015
    Assignees: Trustees of Dartmouth College, Koebenhavns Universitet (University of Copenhagen)
    Inventors: Ethan Dmitrovsky, Xi Liu, Sarah Freemantle, Lorenzo F. Sempere, Charles Cole, Sakari Kauppinen, Mads Bak, Mette Christensen
  • METHOD FOR MULTICOLOR CODETECTION OF MICRORNA AND PROTEINS
    Publication number: 20140147838
    Abstract: The present invention is directed to systems and methods of conducting a purchase transaction of eligible goods or services using a stored value associated with an indicia.
    Type: Application
    Filed: June 16, 2011
    Publication date: May 29, 2014
    Applicant: TRUSTEES OF DARTMOUTH COLLEGE
    Inventors: Lorenzo F. Sempere, Murray Korc
  • Methods for determining response to neoadjuvant therapy and survival using MicroRNA-10b
    Patent number: 8580513
    Abstract: The present invention provides methods for determining response to neoadjuvant therapy and metastasis-free survival in pancreatic ductal adenocarcinoma based upon the level of microRNA expression and optionally the presence of a protein cancer cell marker in biological samples such as formalin-fixed paraffin-embedded specimens using in situ hybridization and optionally an immunohistochemical assay.
    Type: Grant
    Filed: June 29, 2011
    Date of Patent: November 12, 2013
    Assignee: Trustees of Dartmouth College
    Inventors: Lorenzo F. Sempere, Murray Korc, Meir Preis
  • METHODS FOR SCREENING FOR DRUG RESISTANCE IN CANCER TREATMENT
    Publication number: 20130295578
    Abstract: The present invention includes methods for screening for drug resistance in cancer tissue ex vivo which comprises a novel 3-dimensional cell culture system that mimics the tumor microenvironment.
    Type: Application
    Filed: January 10, 2012
    Publication date: November 7, 2013
    Applicant: TRUSTEES OF DARTMOUTH COLLEGE
    Inventors: Lorenzo F. Sempere, Murray Korc
  • microRNA Biomarkers for Human Breast and Lung Cancer
    Publication number: 20130296399
    Abstract: The present invention relates to novel molecular markers for diagnosis and classification of human breast cancer and lung cancer.
    Type: Application
    Filed: May 23, 2012
    Publication date: November 7, 2013
    Inventors: Ethan Dmitrovsky, Xi Liu, Sarah Freemantle, Lorenzo F. Sempere, Charles Cole, Sakari Kauppinen, Mads Bak, Mette Christensen
  • Methods for Determining Response to Neoadjuvant Therapy and Survival Using MicroRNA-10b
    Publication number: 20120021415
    Abstract: The present invention provides methods for determining response to neoadjuvant therapy and metastasis-free survival in pancreatic ductal adenocarcinoma based upon the level of microRNA expression and optionally the presence of a protein cancer cell marker in biological samples such as formalin-fixed paraffin-embedded specimens using in situ hybridization and optionally an immunohistochemical assay.
    Type: Application
    Filed: June 29, 2011
    Publication date: January 26, 2012
    Applicant: TRUSTEES OF DARTMOUTH COLLEGE
    Inventors: Lorenzo F. Sempere, Murray Korc, Meir Preis