Patents by Inventor Lorenzo Franceschini

Lorenzo Franceschini has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • FRONT-LEG ASSISTIVE EXOSKELETON
    Publication number: 20240245569
    Abstract: A front-leg assistive exoskeleton provides the ability to augment a human gait. A shin mount comprising a material secures to a shin of a person such that the shin mount is enabled to push and pull on the shin in a normal direction. A foot mount attaches to a top of a shoe. A connector connects the shin mount to the foot mount. The connector houses an actuator that applies forces that generates torque about an ankle that modifies a gait of the person.
    Type: Application
    Filed: January 25, 2024
    Publication date: July 25, 2024
    Applicant: California Institute of Technology
    Inventors: Lorenzo Franceschini Shaikewitz, Maegan Tucker, Neil C. Janwani, Aaron D. Ames
  • SYNTHETIC DNA TEMPLATE FOR IN VITRO MRNA TRANSCRIPTION
    Publication number: 20230126093
    Abstract: The present invention is related to the manufacturing of mRNA for use in immunotherapy or for use in immunotherapy screening. Compared to existing methods the present approach is plasmid-free, fast and inexpensive, allowing screening of potential neoantigen in immunotherapy.
    Type: Application
    Filed: March 16, 2021
    Publication date: April 27, 2023
    Inventors: Kris Thielemans, Lorenzo Franceschini, Cedric Bogaert
  • Modified nanopores, compositions comprising the same, and uses thereof
    Patent number: 10976300
    Abstract: Provided herein relate to modified or mutant forms of cytolysin A (ClyA) and compositions comprising the same. In particular, the modified or mutant forms of ClyA permits efficient capture and/or translocation of a target negative-charged molecule or polymer through the modified or mutant ClyA nanopores at low or physiological ionic strengths. Thus, methods for using the modified or mutant forms of ClyA and compositions, for example, for characterizing a target negatively-charged analyte, e.g., a target polynucleotide, are also provided.
    Type: Grant
    Filed: December 8, 2016
    Date of Patent: April 13, 2021
    Assignee: Katholieke Universiteit Leuven
    Inventors: Giovanni Maglia, Lorenzo Franceschini, Tine Brouns, Andrew John Heron, Lakmal Nishantha Jayasinghe, Elizabeth Jayne Wallace
  • MODIFIED NANOPORES, COMPOSITIONS COMPRISING THE SAME, AND USES THEREOF
    Publication number: 20180364214
    Abstract: Provided herein relate to modified or mutant forms of cytolysin A (ClyA) and compositions comprising the same. In particular, the modified or mutant forms of ClyA permits efficient capture and/or translocation of a target negative-charged molecule or polymer through the modified or mutant ClyA nanopores at low or physiological ionic strengths. Thus, methods for using the modified or mutant forms of ClyA and compositions, for example, for characterizing a target negatively-charged analyte, e.g., a target polynucleotide, are also provided.
    Type: Application
    Filed: December 8, 2016
    Publication date: December 20, 2018
    Applicant: Katholieke Universiteit Leuven
    Inventors: Giovanni Maglia, Lorenzo Franceschini, Tine Brouns, Andrew John Heron, Lakmal Nishantha Jayasinghe, Elizabeth Jayne Wallace