Patents by Inventor Lorenzo Polenzani
Lorenzo Polenzani has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220211699Abstract: The present invention relates to a pharmaceutical composition which comprises (a) a combination of (i) trazodone or a salt thereof, and (ii) gabapentin or pregabalin or mirogabalin or a salt thereof or a prodrug thereof, and (b) at least one pharmaceutically acceptable excipient, for use in the treatment of neuropathic pain, wherein said pharmaceutical composition comprises a weight ratio of trazodone:gabapentin or pregabalin or mirogabalin between 1:40 and 1:100, preferably lower than 1:40 and up to 1:100.Type: ApplicationFiled: May 6, 2020Publication date: July 7, 2022Applicant: AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO - A.C.R.A.F. S.P.A.Inventors: Lorenzo POLENZANI, Fabrizio CALISTI, Paola LIPONE, Serena TONGIANI
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Patent number: 8686021Abstract: Use of a benzoyl derivative of 3-aminocarbazole to produce a drug for the preventive or therapeutic treatment of a disorder selected form the group comprising inflammatory processes, pain, fever, tumors, Alzheimer's disease and atherosclerosis. Method for the preventive or therapeutic treatment of a disorder selected from the group comprising inflammatory processes, pain, fever, tumors, Alzheimer's disease and atherosclerosis in which a therapeutically effective quantity of a benzoyl derivative of 3-aminocarbazole according to the invention is administered to an individual.Type: GrantFiled: May 3, 2006Date of Patent: April 1, 2014Assignee: Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.p.A.Inventors: Lorenzo Polenzani, Giorgina Mangano, Isabella Coletta, Maria Alessandra Alisi, Nicola Cazzolla, Guido Furlotti, Caterina Maugeri
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Patent number: 8686147Abstract: Compound of formula (I) in which R1, R2 and R3 are defined in the following description, and the pharmaceutically acceptable acid-addition or base-addition salts thereof. The invention also relates to a process and an intermediate for preparing it, and to a pharmaceutical composition comprising it. The invention also relates to the use of a novel 2H-pyrrolo[3,4-c]quinoline compound for preparing a pharmaceutical composition that is active in the treatment of disturbances of the serotoninergic system.Type: GrantFiled: July 17, 2009Date of Patent: April 1, 2014Assignee: Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.p.A.Inventors: Maria Alessandra Alisi, Nicola Cazzolla, Roberta Costi, Roberto Di Santo, Guido Furlotti, Angelo Guglielmotti, Lorenzo Polenzani
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Patent number: 8519139Abstract: The present invention relates to compounds of formula (II)Type: GrantFiled: October 28, 2009Date of Patent: August 27, 2013Assignee: Aziende Chimeche Riunite Angelini Francesco A.C.R.A.F. S.p.A.Inventors: Maria Alessandra Alisi, Nicola Cazzolla, Angelo Guglielmotti, Guido Furlotti, Giuseppe Luna, Lorenzo Polenzani
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Patent number: 8507528Abstract: 2-Alkyl-indazole compound and its pharmaceutically acceptable salts of acid addition, method and intermediates for preparing them, a pharmaceutical composition containing them and use of the latter. The 2-alkyl-indazole compound has the following general formula (I) in which R1, R2, R3, R4, R6, R7, X, Y, W, n, p, and m have the meanings stated in the description.Type: GrantFiled: November 19, 2007Date of Patent: August 13, 2013Assignee: Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.p.A.Inventors: Maria Alessandra Alisi, Nicola Cazzolla, Guido Furlotti, Caterina Maugeri, Rosella Ombrato, Lorenzo Polenzani
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Patent number: 8455519Abstract: The present invention relates to a compound of formula (I): in which: R is a linear or branched alkyl group containing between 1 and 3 carbon atoms, Y is CH or N, and p is an integer between 0 and 3 and preferably 0 and 1, and salts thereof, either acid-addition salts with a pharmaceutically acceptable organic or mineral acid, or base-addition salts with a pharmaceutically acceptable organic or mineral base. The invention also relates to a process for preparing the compound of formula (I), and to a pharmaceutical composition comprising it. The invention also relates to the use of an indazole for preparing a pharmaceutical composition that is active in the treatment of neuropathic pain.Type: GrantFiled: November 6, 2008Date of Patent: June 4, 2013Assignee: Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.p.A.Inventors: Maria Alessandra Alisi, Nicola Cazzolla, Guido Furlotti, Angelo Guglielmotti, Lorenzo Polenzani
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Patent number: 8415476Abstract: An intermediate of formula (II)Type: GrantFiled: December 15, 2009Date of Patent: April 9, 2013Assignee: Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.p.A.Inventors: Maria Alessandra Alisi, Nicola Cazzolla, Guido Furlotti, Angelo Guglielmotti, Lorenzo Polenzani
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Patent number: 8207214Abstract: A method for treating an inflammatory process selected from the group consisting of oedema, erythema, articular inflammation, rheumatoid arthritis, arthrosis, a colorectal tumor, a pulmonary carcinoma, an adenocarcinoma, and combinations thereof, in a person in need thereof, the method comprising administering to the person in need thereof, in an amount sufficient to treat the inflammatory process, a 3-aminocarbazole or a salt thereof.Type: GrantFiled: October 28, 2010Date of Patent: June 26, 2012Assignee: Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.p.A.Inventors: Maria Alessandra Alisi, Patrizia Dragone, Guido Furlotti, Nicola Cazzolla, Vincenzo Russo, Giorgina Mangano, Isabella Coletta, Lorenzo Polenzani
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Patent number: 8017644Abstract: A 2-arylindole compound substituted in position 5, of formula (I): in which X, Y, Z, W, A, R and R? have the meanings given in the description, a pharmaceutical composition comprising it, and also intermediate compounds and a preparation process therefor.Type: GrantFiled: June 14, 2007Date of Patent: September 13, 2011Assignee: Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.p.A.Inventors: Maria Alessandra Alisi, Nicola Cazzolla, Barbara Garofalo, Guido Furlotti, Caterina Maugeri, Rosella Ombrato, Isabella Coletta, Lorenzo Polenzani, Giorgina Mangano, Beatrice Garrone, Angelo Guglielmotti
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Publication number: 20110160201Abstract: Compound of formula (I) in which R1, R2 and R3 are defined in the following description, and the pharmaceutically acceptable acid-addition or base-addition salts thereof. The invention also relates to a process and an intermediate for preparing it, and to a pharmaceutical composition comprising it. The invention also relates to the use of a novel 2H-pyrrolo[3,4-c]quinoline compound for preparing a pharmaceutical composition that is active in the treatment of disturbances of the serotoninergic system.Type: ApplicationFiled: July 17, 2009Publication date: June 30, 2011Applicant: AZIENDE CHIMI. RIUN. ANG. FRANC. A.C.R.A.F. S.p.A.Inventors: Maria Alessandra Alisi, Nicola Cazzolla, Roberta Costi, Roberto Di Santo, Guido Furlotti, Angelo Guglielmotti, Lorenzo Polenzani
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Publication number: 20110046197Abstract: A method for treating an inflammatory process selected from the group consisting of oedema, erythema, articular inflammation, rheumatoid arthritis, arthrosis, a colorectal tumor, a pulmonary carcinoma, an adenocarcinoma, and combinations thereof, in a person in need thereof, the method comprising administering to the person in need thereof, in an amount sufficient to treat the inflammatory process, a 3-aminocarbazole or a salt thereof.Type: ApplicationFiled: October 28, 2010Publication date: February 24, 2011Applicant: AZIENDE CHIMICHE RIUNITE ANGELINI FRANCEInventors: Maria Alessandra ALISI, Patrizia Dragone, Guido Furlotti, Nicola Cazzolla, Vincenzo Russo, Giorgina Mangano, Isabella Coletta, Lorenzo Polenzani
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Patent number: 7879900Abstract: A compound of formula (I), in which R1, R2, R3, R4, R5, R6, X and Y have the meanings indicated in the description, and the pharmaceutically acceptable salts thereof. A pharmaceutical composition containing a compound of formula (I) or a pharmaceutically acceptable salt thereof. A method for preparing the abovementioned compound of formula (I) and the pharmaceutically acceptable salts thereof.Type: GrantFiled: July 25, 2006Date of Patent: February 1, 2011Assignee: Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.p.A.Inventors: Maria Alessandra Alisi, Patrizia Dragone, Guido Furlotti, Nicola Cazzolla, Vincenzo Russo, Giorgina Mangano, Isabella Coletta, Lorenzo Polenzani
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Publication number: 20100215742Abstract: The present invention relates to a compound of formula (I): in which: R is a linear or branched alkyl group containing between 1 and 3 carbon atoms, Y is CH or N, and p is an integer between 0 and 3 and preferably 0 and 1, and salts thereof, either acid-addition salts with a pharmaceutically acceptable organic or mineral acid, or base-addition salts with a pharmaceutically acceptable organic or mineral base. The invention also relates to a process for preparing the compound of formula (I), and to a pharmaceutical composition comprising it. The invention also relates to the use of an indazole for preparing a pharmaceutical composition that is active in the treatment of neuropathic pain.Type: ApplicationFiled: November 6, 2008Publication date: August 26, 2010Applicant: AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.p.A.Inventors: Maria Alessandra Alisi, Nicola Cazzolla, Guido Furlotti, Angelo Guglielmotti, Lorenzo Polenzani
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Publication number: 20100094015Abstract: An intermediate of formula (II)Type: ApplicationFiled: December 15, 2009Publication date: April 15, 2010Applicant: AZIENDE CHIM. RIUN. ANGEL. FRA. A.C.R.A.F. S.p.A.Inventors: Maria Alessandra Alisi, Nicola Cazzolla, Guido Furlotti, Angelo Guglielmotti, Lorenzo Polenzani
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Publication number: 20100056573Abstract: 2-Alkyl-indazole compound and its pharmaceutically acceptable salts of acid addition, method and intermediates for preparing them, a pharmaceutical composition containing them and use of the latter. The 2-alkyl-indazole compound has the following general formula (I) in which R1, R2, R3, R4, R6, R7, X, Y, W, n, p, and m have the meanings stated in the description.Type: ApplicationFiled: November 19, 2007Publication date: March 4, 2010Applicant: AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A.Inventors: Maria Alessandra Alisi, Nicola Cazzolla, Guido Furlotti, Caterina Maugeri, Rosella Ombrato, Lorenzo Polenzani
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Publication number: 20100048907Abstract: The present invention relates to compounds of formula (II)Type: ApplicationFiled: October 28, 2009Publication date: February 25, 2010Applicant: AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO S.P.A.Inventors: Maria Alessandra ALISI, Nicola Cazzolla, Angelo Guglielmotti, Guido Furlotti, Giuseppe Luna, Lorenzo Polenzani
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Patent number: 7662836Abstract: An indazole having analgesic activity, a method for the preparation thereof and a pharmaceutical composition containing the same; the indazole has the following general formula: where X, Ra, Rb, Rc and Rd have the meanings stated in the description.Type: GrantFiled: April 23, 2004Date of Patent: February 16, 2010Assignee: Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.p.A.Inventors: Maria Alessandra Alisi, Nicola Cazzolla, Guido Furlotti, Angelo Guglielmotti, Lorenzo Polenzani
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Patent number: 7638534Abstract: Use of a compound of formula (I), wherein X is CH or N, and when X is CH, R is H, OH, a linear or branched alkyl chain having from 1 to 3 carbon atoms, a linear or branched alkoxy chain having from 1 to 3 carbon atoms, or a halogen atom, and when X is N, R is H, or an acid addition salt thereof with a pharmaceutically acceptable organic or inorganic acid, to prepare a pharmaceutical composition active in the treatment of neuropathic pain.Type: GrantFiled: July 8, 2004Date of Patent: December 29, 2009Assignee: Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.p.A.Inventors: Angelo Guglielmotti, Lorenzo Polenzani, Alessandra Alisi, Nicola Cazzolla
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Patent number: 7632849Abstract: An indazolamide (I), wherein X, R1, R2, R3, R4, R5, R6, R7 and R8 have the meanings given in the description, and addition salts thereof with a pharmaceutically acceptable acid, a method for the preparation thereof and a pharmaceutical composition containing the same.Type: GrantFiled: January 26, 2004Date of Patent: December 15, 2009Assignee: Aziende Chimiche Riunite Angelini Francesco A.C.R.A.F. S.p.A.Inventors: Maria Alessandra Alisi, Nicola Cazzolla, Angelo Guglielmotti, Guido Furlotti, Giuseppe Luna, Lorenzo Polenzani
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Publication number: 20090186922Abstract: A 2-arylindole compound substituted in position 5, of formula (I): in which X, Y, Z, W, A, R and R? have the meanings given in the description, a pharmaceutical composition comprising it, and also intermediate compounds and a preparation process therefor.Type: ApplicationFiled: June 14, 2007Publication date: July 23, 2009Applicant: AZIENDE CHIM. RIUN. ANG. FRANC. A.C.R.A.F. S.p.A.Inventors: Maria Alessandra Alisi, Nicola Cazzolla, Barbara Garofalo, Guido Furlotti, Caterina Maugeri, Rosella Ombrato, Isabella Coletta, Lorenzo Polenzani, Giorgina Mangano, Beatrice Garrone, Angelo Guglielmotti