Abstract: A heat pump system is provided. The heat pump system includes a first compressor and a second compressor and a first heat exchanger, a second heat exchanger, and a third heat exchanger. The system further includes a first expansion device, a second expansion device, and a third expansion device. When the system operates in a cascade heating mode, the third heat exchanger is configured to: receive a first portion of refrigerant from the first compressor and a second portion of refrigerant from the second compressor, and provide a first consistent flow of refrigerant to the first compressor and a second consistent flow of refrigerant to the second compressor so as to improve an efficiency of the system.

Abstract: Disclosed herein are apparatuses and methods for treating neurological disorders by electro-stimulation. The apparatus (10) for treating neurological disorders includes at least one electrode (12) implantable in the brain of a patient, and a processing and stimulation device (14) connected to the at least one electrode (12). The processing and stimulation device (14) may include a stimulation module (16) configured to generate a stimulation signal to be sent to the at least one electrode (12), and an acquisition module (20) that measures cerebral activity coming from the brain of the patient. The acquisition module (20) may have a front-end block (27) configured to amplify the potential difference of its input signals (V1a, V2a) and to filter a stimulus artifact and may include a multi-stage fully-differential switched capacitor circuit (e.g., an integrated circuit) configured for discrete-time signal processing.

Abstract: The present disclosure relates to apparatuses and methods for treating neurological disorders by electro-stimulation. In some embodiments, the apparatus includes a stimulation module configured to generate a stimulation signal to be sent to at least one implantable electrode, and an acquisition module configured to acquire a signal measured by the at least one implantable electrode from a patient. The acquisition module may include a front-end block configured to amplify a potential difference of input signals (V1a, V2a) received by the acquisition module and to filter a stimulus artifact by cutting off frequencies above a predefined frequency band. The front-end block may include a multi-stage fully-differential switched capacitor circuit configured for discrete-time signal processing.

Abstract: In some variations provided herein, a system for deep brain stimulation includes an implantable device that acquire and store neural activity signal records and apply electrical stimulation. The system further includes a personal controller device that establishes a first wireless connection to the implantable device. The personal controller device transmits power to the implantable device, and the implantable device transmits neural activity signal records to the personal controller device over the first wireless connection. The system further includes a clinician programmer device that receive the neural activity signal records from the implantable device by establishing a second wireless connection based on activation of the first wireless connection. The clinician programmer device sets one or more stimulation parameters based on the neural activity signal records.

Abstract: Disclosed herein are compositions, methods, and kits for suppression in huanglongbing (HLB) in a subject having HLB (or otherwise for treatment of symptoms of HLB in a subject in need thereof. In embodiments, compositions and methods as described herein comprise compositions relating to oak leaf extract to applied to or around citrus plants having or suspected of having HLB.

Abstract: Disclosed herein are apparatuses and methods for treating neurological disorders by electro-stimulation. The apparatus (10) for treating neurological disorders includes at least one electrode (12) implantable in the brain of a patient, and a processing and stimulation device (14) connected to the at least one electrode (12). The processing and stimulation device (14) may include a stimulation module (16) configured to generate a stimulation signal to be sent to the at least one electrode (12), and an acquisition module (20) that measures cerebral activity coming from the brain of the patient. The acquisition module (20) may have a front-end block (27) configured to amplify the potential difference of its input signals (V1a, V2a) and to filter a stimulus artifact and may include a multi-stage fully-differential switched capacitor circuit (e.g., an integrated circuit) configured for discrete-time signal processing.

Abstract: Disclosed herein are apparatuses and methods for treating neurological disorders by electro-stimulation. The apparatus for treating neurological disorders includes at least one electrode implantable in the brain of a patient, and a processing and stimulation device connected to the at least one electrode. The processing and stimulation device may include a stimulation module configured to generate a stimulation signal to be sent to the at least one electrode, and an acquisition module that measures cerebral activity coming from the brain of the patient. The acquisition module may have a front-end block configured to amplify the potential difference of its input signals (V1a, V2a) and to filter a stimulus artifact and may include a multi-stage fully-differential switched capacitor circuit (e.g., an integrated circuit) configured for discrete-time signal processing.

Abstract: The present invention concerns an apparatus for treating neurological disorders comprising (i) at least one electrode implantable in the brain of a patient and (ii) a processing and stimulation device connected to the at least one electrode, wherein the processing and stimulation device comprises (a) at least one stimulation module adapted to generate a stimulation signal to be sent to the at least one electrode, the stimulation signal being characterised by a plurality of parameters, (b) at least one acquisition module of a signal characteristic of cerebral activity coming from the brain of the patient adapted to determine its power in at least one frequency band, and (c) at least one control module of at least one parameter of the stimulation signal as a function of the power of the signal characteristic of cerebral activity acquired, based on a transfer function having a saturating trend, wherein the transfer function is such as to set the at least one parameter (Va, Vd, Vf) of the stimulation signal (Vsti

Abstract: The method for handling goods involves providing an automated guided vehicle (1), provided with a three-dimensional laser sensor, and carrying out the calibration of said automated guided vehicle (1). The next step involves moving said automated guided vehicle (1) within a workplace where said goods are stored, and collecting data relating to the three-dimensional spatial configuration of said workplace using said three-dimensional laser sensor. Said collected data are then compared with a three-dimensional map of said workplace stored in a storage memory of an internal control unit of said automated guided vehicle (1) and the absolute position of said automated guided vehicle (1) is detected.

Abstract: An apparatus for treating neurological disorders comprising at least one electrode implantable in a patient's brain and a processing and stimulation device connected to the at least one electrode. The processing and stimulation device comprises at least one stimulation module adapted to generate a stimulation signal characterised by a plurality of parameters; at least one acquisition module adapted to acquire a signal characteristic of cerebral activity and determine its power in at least one frequency band; and at least one control module of at least one parameter of the stimulation signal as a function of the power of the signal characteristic of cerebral activity acquired, based on a transfer function having a saturating trend, wherein the transfer function is configured to set the at least one parameter of the stimulation signal differently dependent on a plurality of power ranges, by keeping the parameter within a predetermined stimulation range.

Abstract: Disclosed herein are apparatuses and methods for treating neurological disorders by electro-stimulation. The apparatus (10) for treating neurological disorders includes at least one electrode (12) implantable in the brain of a patient, and a processing and stimulation device (14) connected to the at least one electrode (12). The processing and stimulation device (14) may include a stimulation module (16) configured to generate a stimulation signal to be sent to the at least one electrode (12), and an acquisition module (20) that measures cerebral activity coming from the brain of the patient. The acquisition module (20) may have a front-end block (27) configured to amplify the potential difference of its input signals (V1a,V2a) and to filter a stimulus artifact and may include a multi-stage fully-differential switched capacitor circuit (e.g., an integrated circuit) configured for discrete-time signal processing.

Abstract: An apparatus for treating neurological disorders comprising at least one electrode implantable in a patient's brain and a processing and stimulation device connected to the at least one electrode. The processing and stimulation device comprises at least one stimulation module adapted to generate a stimulation signal characterised by a plurality of parameters; at least one acquisition module adapted to acquire a signal characteristic of cerebral activity and determine its power in at least one frequency band; and at least one control module of at least one parameter of the stimulation signal as a function of the power of the signal characteristic of cerebral activity acquired, based on a transfer function having a saturating trend, wherein the transfer function is configured to set the at least one parameter of the stimulation signal differently dependent on a plurality of power ranges, by keeping the parameter within a predetermined stimulation range.

Abstract: The invention proposes a system and a method for controlling the process of prescription and administration of direct current stimulation treatments in humans. In the proposed system, the stimulation parameters are all set by a specialist whose credentials are verified through a specific control device different from the device that delivers electrical stimulation. The stimulating device can deliver the stimulation only if the credentials of the specialized subject making the prescription are verified and if the prescription is made according to safety criteria. The system is composed by at least one device for the administration of electrical current connected to two electrodes applied over the skin and by a control device. The control device is connected to one or more devices for the administration of the direct current through a communication channel. The specialist gives his own credentials and is authorized at making the prescription and, accordingly, programming the stimulating device.

Abstract: A method for diagnosing or prognosticating hepatocellular carcinoma, also in the early stages, or for assessing the risk of developing hepatocellular carcinoma, or for monitoring the effectiveness of an anti-tumour therapy against hepatocellular carcinoma by measuring the expression level of at least one miRNA gene product in a peripheral blood sample or in a biological fluid sample. Said method comprises measuring, in an isolated sample of peripheral blood or biological fluid, the expression level of at least one miRNA gene product, and comparing said measured expression level with a reference level. Such method can also be used to diagnose or assess the risk of developing liver cirrhosis in patients affected by chronic hepatitis, or to prognosticate the evolution of cirrhosis in patients affected by cirrhosis, or to monitor the effectiveness of a pharmacological therapy against liver cirrhosis.

Abstract: An apparatus and a related method for the deep brain stimulation have been invented wherein the parameters of the stimulation supplied at the human nervous system level are adjusted and optimized continuously by the analysis of the bioelectric signals coming from the tissue adjacent the stimulation electrode itself, adapting the therapy continuously and in line to the patient's clinical state. The apparatus is constituted at least by an electro-catheter (1) implantable in a patient's brain and equipped with four contacts (4, 5, 6, 7). Then, there is at least a stimulation module (9) which generates the stimulating signal (15) sent to the electro-catheter (1) and in particular to one of the contacts thereof (6). The electro-catheter (1) contemporarily sends a signal characterizing the brain activity coming from the tissue involved by the stimulating signal (15) to an acquisition module (8).

Abstract: The invention proposes a system and a method for controlling the process of prescription and administration of direct current stimulation treatments in humans. In the proposed system, the stimulation parameters are all set by a specialist whose credentials are verified through a specific control device different from the device that delivers electrical stimulation. The stimulating device can deliver the stimulation only if the credentials of the specialized subject making the prescription are verified and if the prescription is made according to safety criteria. The system is composed by at least one device for the administration of electrical current connected to two electrodes applied over the skin and by a control device. The control device is connected to one or more devices for the administration of the direct current through a communication channel. The specialist gives his own credentials and is authorized at making the prescription and, accordingly, programming the stimulating device.

Abstract: An apparatus and a related method for the deep brain stimulation have been invented wherein the parameters of the stimulation supplied at the human nervous system level are adjusted and optimized continuously by the analysis of the bioelectric signals coming from the tissue adjacent the stimulation electrode itself, adapting the therapy continuously and in line to the patient's clinical state. The apparatus is constituted at least by an electro-catheter (1) implantable in a patient's brain and equipped with four contacts (4, 5, 6, 7). Then, there is at least a stimulation module (9) which generates the stimulating signal (15) sent to the electro-catheter (1) and in particular to one of the contacts thereof (6). The electro-catheter (1) contemporarily sends a signal characterizing the brain activity coming from the tissue involved by the stimulating signal (15) to an acquisition module (8).