Patents by Inventor Loreto Gesualdo

Loreto Gesualdo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMBINATION OF A UBIQUITIN-CONJUGATING ENZYME COMPLEX INHIBITOR AND ANTIHYPERTENSIVE AND/OR HYPOGLYCEMIC DRUGS IN DIABETIC KIDNEY DISEASE
    Publication number: 20210015785
    Abstract: The present invention relates to a composition comprising at least one inhibitor of the enzymatic complex conjugating ubiquitin Ubc13/Uev1a and at least one anti-hypertensive agent inhibiting the renin-angiotensin-aldosterone system and/or a hypoglycemic agent. Medical uses and pharmaceutical compositions comprising this composition also fall within the scope of the present invention. In particular, this composition can be used for the treatment or prevention of the renal fibrotic damage, in particular in patients suffering from diabetes.
    Type: Application
    Filed: March 28, 2019
    Publication date: January 21, 2021
    Inventors: Loreto GESUALDO, Paola PONTRELLI
  • Renal carcinoma cell line and uses thereof
    Patent number: 8128923
    Abstract: The present invention relates to a renal carcinoma cell line capable of activating the immune system in an antigen-specific manner. According to a further aspect, the invention also includes derivatives of the cell line that maintain said activation capacity. The invention also comprises a method for targeting and activating immune system cells against cells of clear cell renal carcinoma. Said method comprises the co-incubation of isolated immune system cells (dendritic cells, CD4+, CD8+ lymphocytes etc.) with cells of the RCC BA85#21 line in accordance with the invention in a suitable culture medium, for a time sufficient to obtain antigen specific cells.
    Type: Grant
    Filed: October 20, 2006
    Date of Patent: March 6, 2012
    Assignees: Universita' Degli Studi Di Bari, Universita' Degli Studi Di Foggia
    Inventors: Elena Ranieri, Michele Battaglia, Herr Wolfgang, Loreto Gesualdo
  • Renal Carcinoma Cell Line and Uses thereof
    Publication number: 20090136458
    Abstract: The present invention relates to a renal carcinoma cell line capable of activating the immune system in an antigen-specific manner. According to a further aspect, the invention also includes derivatives of the cell line that maintain said activation capacity. The invention also comprises a method for targeting and activating immune system cells against cells of clear cell renal carcinoma. Said method comprises the co-incubation of isolated immune system cells (dendritic cells, CD4+, CD8+ lymphocytes etc.) with cells of the RCC BA85#21 line in accordance with the invention in a suitable culture medium, for a time sufficient to obtain antigen specific cells.
    Type: Application
    Filed: October 20, 2006
    Publication date: May 28, 2009
    Inventors: Elena Ranieri, Michele Battaglia, Herr Wolfgang, Loreto Gesualdo