Patents by Inventor Lori A. Schretzman

Lori A. Schretzman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Heteroarylakanoic acids as intergrin receptor antagonists
    Patent number: 7119098
    Abstract: The present invention relates to a class of compounds represented by formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of Formula (I), and methods of selectively antagonizing the ???3 and/or the ???5 integrin without significantly antagonizing the IIb/IIIa integrin.
    Type: Grant
    Filed: June 15, 2001
    Date of Patent: October 10, 2006
    Assignee: Pharmacia Corporation
    Inventors: Srinivasan Raj Nagarajan, Ish Kumar Khanna, Michael B. Tollefson, Scott B. Mohler, Barbara B. Chen, Mark Russell, Balekudru Devadas, Thomas D. Penning, Lori A. Schretzman, Dale P. Spangler, Mark L. Boys, Nizal S. Chandrakumar, Hwang-Fun Lu
  • Heteroarylalkanoic acids as integrin receptor antagonists
    Patent number: 6933304
    Abstract: The present invention relates to a class of compounds represented by the Formula I or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the Formula I, and methods of selectively antagonizing the ?V?3 and/or the ?V?5 integrin without significantly antagonizing the IIb/IIIa or ?V?6 integrin.
    Type: Grant
    Filed: June 15, 2001
    Date of Patent: August 23, 2005
    Assignee: Pharmacia Corporation
    Inventors: Srinivasan Raj Nagarajan, Ish Kumar Khanna, Michael B. Tollefson, Scott B. Mohler, Barbara Chen, Mark Russell, Balekudru Devadas, Thomas D. Penning, Lori A. Schretzman, Dale P. Spangler, Mark Laurence Boys, Nizal Samuel Chandrakumar, Hung-Fun Lu
  • Heteroarylalkanoic acids as integrin receptor antagonists derivatives
    Publication number: 20050043344
    Abstract: The present invention relates to pharmaceutical compositions comprising compounds of the Formula I, or a pharmaceutically acceptable salt thereof, and methods of selectively inhibiting or antagonizing the ?V?3 and/or the ?V?5 integrin without significantly inhibiting the ?V?6 integrin.
    Type: Application
    Filed: December 22, 2003
    Publication date: February 24, 2005
    Inventors: Mark Boys, Lori Schretzman, Michael Tollefson, Nizal Chandrakumar, Ish Khanna, Maria Nguyen, Victoria Downs, Scott Mohler, Glen Gesicki, Thomas Penning, Barbara Chen, Yaping Wang, Albert Khilevich, Bipinchandra Desai, Yi Yu, John Wendt, Heather Stenmark, Hongwei Wu, Renee Huff, Srinivasan Nagarajan, Balekudru Devadas, Hwang-Fun Lu, Mark Russell, Dale Spangler, Mihir Parikh
  • 2-amino-benzoxazinones for the treatment of viral infections
    Publication number: 20050032793
    Abstract: A class of compounds for the treatment of viral infections. Compounds of particular interest are defined by Formula I wherein R-R4 are as defined herein, or a pharmaceutically-acceptable salt thereof.
    Type: Application
    Filed: December 8, 2003
    Publication date: February 10, 2005
    Applicant: G.D. Searle & Co.
    Inventors: Norman Abood, Daniel Flynn, Daniel Becker, Brian Bax, Hui Li, Roger Nosal, Lori Schretzman, Clara Villamil
  • Heteroarylakanoic acids as intergrin receptor antagonists
    Publication number: 20040092497
    Abstract: The present invention relates to a class of compounds represented by formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of Formula (I), and methods of selectively antagonizing the &agr;&ngr;&bgr;3 and/or the &agr;&ngr;&bgr;5 integrin without significantly antagonizing the IIb/IIIa integrin.
    Type: Application
    Filed: September 5, 2003
    Publication date: May 13, 2004
    Inventors: Srinivasan Raj Nagarajan, Ish Kumar Khanna, Michael B. Tollefson, Scott B, Mohler, Barbara B. Chen, Mark Russell, Balekudru Devadas, Thomas D. Penning, Lori A. Schretzman, Dale P. Spangler, Mark L. Boys, Nizal S. Chandrakumar, Hwang-Fun Lu
  • Gem-substituted alpha v beta 3 antagonists
    Publication number: 20040043994
    Abstract: The present invention relates to a class of compounds represented by the Formula I.
    Type: Application
    Filed: January 21, 2003
    Publication date: March 4, 2004
    Inventors: Ish Kumar Khanna, Yi Yu, Hwang-Fun Lu, Nizal S. Chandrakumar, Renee M. Huff, Mark Russell, Mark L. Boys, Lori A. Schretzman, Barbara B. Chen, Bipinchandra N. Desai, Srinivasan Raj Nagarajan, Alan F. Gasiecki, Thomas D. Penning, Thomas Rogers, John Adam Wendt, Albert Khilevich, Yaping Wang
  • 2-Amino-benzoxazinones for the treatment of viral infections
    Patent number: 6683077
    Abstract: A class of compounds for the treatment of viral infections. Compounds of particular interest are defined by Formula I wherein R-R4 are as defined herein, or a pharmaceutically-acceptable salt thereof.
    Type: Grant
    Filed: January 4, 2002
    Date of Patent: January 27, 2004
    Assignee: G.D. Searle & Co.
    Inventors: Norman Abood, Daniel L. Flynn, Daniel P. Becker, Brian M. Bax, Hui Li, Roger A. Nosal, Lori A. Schretzman, Clara I. Villamil
  • Gem-substituted &agr;v&bgr;3 antagonists
    Patent number: 6531494
    Abstract: The present invention relates to a class of compounds represented by the Formula I. or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the Formula I, and methods of selectively inhibiting or antagonizing the &agr;V&bgr;3 and/or the &agr;V&bgr;5 integrin.
    Type: Grant
    Filed: August 29, 2001
    Date of Patent: March 11, 2003
    Assignee: Pharmacia Corporation
    Inventors: Ish Kumar Khanna, Yi Yu, Balekudru Devadas, Hwang-Fun Lu, Nizal S Chandrakumar, Renee M. Huff, Bipinchandra N. Desai, Srinivasan Raj Nagarajan, Alan F. Gasiecki, Thomas D. Penning, Mark A. Russell, Mark L. Boys, Lori A. Schretzman, Barbara B. Chen, Thomas Rogers, John Adam Wendt, Albert Khilevich, Yaping Wang
  • 2-Amino-benzoxazinones for the treatment of viral infections
    Publication number: 20030022895
    Abstract: A class of compounds for the treatment of viral infections.
    Type: Application
    Filed: January 4, 2002
    Publication date: January 30, 2003
    Applicant: G.D. Searle & Co.
    Inventors: Norman Abood, Daniel L. Flynn, Daniel P. Becker, Brian M. Bax, Hui Li, Roger A. Nosal, Lori A. Schretzman, Clara I. Villamil
  • Heteroarylalkanoic acids as integrin receptor antagonists
    Publication number: 20020133023
    Abstract: The present invention relates to a class of compounds represented by the Formula I 1
    Type: Application
    Filed: June 15, 2001
    Publication date: September 19, 2002
    Inventors: Srinivasan Raj Nagarajan, Ish Kumar Khanna, Michael B. Tollefson, Scott B. Mohler, Barbara Chen, Mark Russell, Balekudru Devadas, Thomas D. Penning, Lori A. Schretzman, Dale P. Spangler, Mark Laurence Boys, Nizal Samuel Chandrakumar, Hung-Fun Lu
  • 2-amino benzoxazinones for the treatment of viral infections
    Patent number: 6380189
    Abstract: A class of compounds for the treatment of viral infections. Compounds of particular interest are defined by Formula I wherein R-R4 are as defined herein, or a pharmaceutically-acceptable salt thereof.
    Type: Grant
    Filed: February 11, 2000
    Date of Patent: April 30, 2002
    Assignee: G.D. Searle & Co.
    Inventors: Norman Abood, Daniel L. Flynn, Daniel P. Becker, Brian M. Bax, Hui Li, Roger A. Nosal, Lori A. Schretzman, Clara I. Villamil
  • Double prodrugs of potent GP IIb/IIIa antagonists
    Patent number: 6025358
    Abstract: The present invention relates to double prodrugs of pharmacologically active glycoprotein IIb/IIIa antagonists of the formula ##STR1## wherein R.sub.1 is selected from the group consisting of lower alkyl of about 2 to about 8 carbon atoms, cycloalkyl, and aralkyl; R is selected from the group consisting of alkoxy, ##STR2## wherein R.sup.50 is H or alkyl; and ##STR3## wherein R.sup.50 is H or alkyl; and pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: May 19, 1999
    Date of Patent: February 15, 2000
    Assignee: G. D. Searle & Co.
    Inventors: Norman Anthony Abood, Michael J. Bennett, Lori A. Schretzman
  • 2-amino-benzoxazinones for the treatment of viral infections
    Patent number: 5985872
    Abstract: A class of compounds for the treatment of viral infections. Compounds of particular interest are defined by Formula II ##STR1## wherein R.sup.28 is selected from (a) amino substituted with one or two radicals selected from alkyl, aralkyl, heterocycoalkyl, heterocyclo, and aryl, and (b) amino acid residues and derivatives thereof; wherein R.sup.29 is selected from hydrido, alkyl, halo, ##STR2## wherein R.sup.30 is selected from alkyl, alkoxy, alkylamino, carboxyalkyl, alkoxyalkyl, alkylaminoalkyl, cycloalkyl, heterocyclo, heterocycloalkyl, heterocycloalkoxy, alkylaminoalkoxy, alkylaminoalkylamino, heterocycloalkylamino, and N-aralkylamino; wherein R.sup.31 is alkyl; wherein R.sup.32 is alkyl and aryl; or a pharmaceutically-acceptable salt thereof.
    Type: Grant
    Filed: May 24, 1995
    Date of Patent: November 16, 1999
    Assignee: G.D. Searle & Co.
    Inventors: Norman Anthony Abood, Daniel L. Flynn, Daniel P. Becker, Brian M. Bax, Hui Li, Roger A. Nosal, Lori A Schretzman, Clara I Villamil
  • Process for the preparation of amidino phenyl pyrrolidine beta-alanine urea analogs
    Patent number: 5610296
    Abstract: The invention herein is directed to a process for producing a lactam of the formula ##STR1## from a methionine analog of the formula ##STR2## by treating the methionine analog with trimethylsulfonium halide or trimethylsulfoxonium halide in the presence of a base in a suitable aprotic solvent.The invention herein is further directed to the preparation of amidinophenyl pyrrolidinyl .beta.-alanine urea analogs using such methionine and lactam compounds as intermediates, which .beta.-alanine urea analogs are useful as antithrombotics.
    Type: Grant
    Filed: December 5, 1994
    Date of Patent: March 11, 1997
    Assignee: G. D. Searle & Co.
    Inventors: Norman A. Abood, Daniel L. Flynn, Scott A. Laneman, Roger Nosal, Lori A. Schretzman
  • Process for the preparation of amidino phenyl pyrrolidine .beta.-alanine urea analogs
    Patent number: 5576447
    Abstract: The invention herein is directed to a process for producing a lactam of the formula ##STR1## from a methionine analog of the formula ##STR2## by treating the methionine analog with trimethylsulfonium halide or trimethylsulfoxonium halide in the presence of a base in a suitable aprotic solvent.The invention herein is further directed to the preparation of amidinophenyl pyrrolidinyl .beta.-alanine urea analogs using such methionine and lactam compounds as intermediates, which .beta.-alanine urea analogs are useful as antithrombotics.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: November 19, 1996
    Assignee: G. D. Searle & Co.
    Inventors: Norman A. Abood, Daniel L. Flynn, Scott A. Laneman, Roger Nosal, Lori A. Schretzman
  • Process for the preparation of amidino phenyl pyrrolidine .beta.-alanine urea analogs
    Patent number: 5484946
    Abstract: The invention herein is directed to a process for producing a lactam of the formula ##STR1## from a methionine analog of the formula ##STR2## by treating the methionine analog with trimethylsulfonium halide or trimethylsulfoxonium halide in the presence of a base in a suitable aprotic solvent.The invention herein is further directed to the preparation of amidinophenyl pyrrolidinyl .beta.-alanine urea analogs using such methionine and lactam compounds as intermediates, which .beta.-alanine urea analogs are useful as antithrombotics.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: January 16, 1996
    Assignee: G. D. Searle & Co.
    Inventors: Norman A. Abood, Daniel L. Flynn, Scott A. Laneman, Roger Nosal, Lori A. Schretzman
  • Phenyl amidines derivatives useful as platelet aggregation inhibitors
    Patent number: 5481021
    Abstract: This invention relates to phenyl amidine derivatives having the following formula ##STR1## or a pharmaceutically acceptable salt which are useful in the inhibition of platelet aggregation. This invention also relates to pharmaceutical compositions of such phenyl amidine derivatives.
    Type: Grant
    Filed: December 22, 1994
    Date of Patent: January 2, 1996
    Assignee: G. D. Searle & Co.
    Inventors: Robert B. Garland, Masateru Miyano, Jeffery A. Zablocki, Lori A. Schretzman