Patents by Inventor Lori Ann Jones

Lori Ann Jones has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Chimeric receptors for the generation of selectively-activatable TH-independent cytotoxic T cells
    Patent number: 6083751
    Abstract: The invention provides cytotoxic T lymphocytes that express a chimeric cell surface receptor. The chimeric receptor enables the lymphocytes to become activated and to proliferate (via a T.sub.H -independent autocrine cycle) in response to adhesion between the lymphocyte and an antigen displaying cell (ADC) that might not normally activate the T cell. The chimeric receptors of the present invention comprise fusion polypeptides of the following structure:XC--TM--IC28wherein (XC) is an extracellular region derived from a receptor for a ligand that is expressed on the surface of an antigen-displaying cell, fused via a transmembrane region is (TM) to an intracellular region (IC28) which is derived from the intracellular region of the CD28 receptor.
    Type: Grant
    Filed: November 1, 1995
    Date of Patent: July 4, 2000
    Assignee: Targeted Genetics Corporation
    Inventors: Andrew Lawrence Feldhaus, Lori Ann Jones