Patents by Inventor Lori Friedman

Lori Friedman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Sppls as Modifiers of the P53 Pathway and Methods of Use
    Publication number: 20070286852
    Abstract: Human SPPL genes are identified as modulators of the p53 pathway, and thus are therapeutic targets for disorders associated with defective p53 function. Methods for identifying modulators of p53, comprising screening for agents that modulate the activity of SPPL are provided.
    Type: Application
    Filed: June 18, 2004
    Publication date: December 13, 2007
    Applicant: Exelixis, Inc.
    Inventors: Marcia Belvin, Helen Francis-Lang, Lori Friedman, Gregory Plowman, Monique Nicoll, Timothy Heuer
  • Man2as as Modifiers of the Igfr Pathway and Methods of Use
    Publication number: 20070264268
    Abstract: Human MIGFR genes are identified as modulators of the IGFR pathway, and thus are therapeutic targets for disorders associated with defective IGFR function. Methods for identifying modulators of IGFR, comprising screening for agents that modulate the activity of MIGFR are provided.
    Type: Application
    Filed: January 27, 2005
    Publication date: November 15, 2007
    Applicant: EXELIXIS, INC.
    Inventors: Lori Friedman, Helen Francis-Lang, Annette Parks, Kenneth Shaw, HaiGuang Zhang, Timothy Heuer
  • HPRP4s Modifiers of the p53 Pathway and Methods of Use
    Publication number: 20070160539
    Abstract: Human hPRP4 genes are identified as modulators of the p53 pathway, and thus are therapeutic targets for disorders associated with defective p53 function. Methods for identifying modulators of p53, comprising screening for agents that modulate the activity of hPRP4 are provided.
    Type: Application
    Filed: January 26, 2007
    Publication date: July 12, 2007
    Applicant: EXELIXIS, INC.
    Inventors: Lori Friedman, Gregory Plowman, Tak Hung, Helen Francis-Lang, Danxi Li, Roel Funke, Michael Costa
  • Sphks as modifiers of the p53 pathway and methods of use
    Publication number: 20060252035
    Abstract: Human SPHK genes are identified as modulators of the p53 pathway, and thus are therapeutic targets for disorders associated with defective p53 function. Methods for identifying modulators of p53, comprising screening for agents that modulate the activity of SPHK are provided.
    Type: Application
    Filed: August 2, 2002
    Publication date: November 9, 2006
    Inventors: Lori Friedman, Gregory Plowman, Michael Costa, Danxi Li, Roel Funke, Tak Hung
  • LIMKs as modifiers of p53 pathway and methods of use
    Publication number: 20060160764
    Abstract: Human LIMK genes are identified as modulators of the p53 pathway, and thus are therapeutic targets for disorders associated with defective p53 function. Methods for identifying modulators of p53, comprising screening for agents that modulate the activity of LIMK are provided.
    Type: Application
    Filed: March 17, 2006
    Publication date: July 20, 2006
    Applicant: Exelixis, Inc.
    Inventors: Lori Friedman, Gregory Plowman, Marcia Belvin, Helen Francis-Lang, Danxi Li, Roel Funke
  • Gfats as modifiers of the p53 pathway and methods of use
    Publication number: 20060121457
    Abstract: Human GFAT genes are identified as modulators of the p53 pathway, and thus are therapeutic targets for disorders associated with defective p53 function. Methods for identifying modulators of p53, comprising screening for agents that modulate the activity of GFAT are provided.
    Type: Application
    Filed: June 2, 2002
    Publication date: June 8, 2006
    Inventors: Lori Friedman, Gregory Plowman, Marcia Belvin, Helen Francis-Lang, Danxi Li, Roel Funke
  • Gpcs as modifiers of the irrtk p21 pathways and methods of use
    Publication number: 20060121041
    Abstract: Human GPC genes are identified as modulators of the IRRTK or p21 pathways, and thus are therapeutic targets for disorders associated with defective IRRTK or p21 function. Methods for identifying modulators of IRRTK or p21, comprising screening for agents that modulate the activity of GPC are provided.
    Type: Application
    Filed: July 10, 2002
    Publication date: June 8, 2006
    Inventors: Lori Friedman, Gregory Plowman, Tom Kidd, Roel Funke, Danxi Li, Siobhan Roche
  • PRMTs as modifiers of the p53 pathway and methods of use
    Patent number: 7049088
    Abstract: Human PRMT genes are identified as modulators of the p53 pathway, and thus are therapeutic targets for disorders associated with defective p53 function. Methods for identifying modulators of p53, comprising screening for agents that modulate the activity of PRMT are provided.
    Type: Grant
    Filed: June 5, 2002
    Date of Patent: May 23, 2006
    Assignee: Exelixis, INC
    Inventors: Lori Friedman, Gregory D. Plowman, Marcia Belvin, Helen Francis-Lang, Danxi Li, Roel P. Funke, Rolf Peter Ryseck, Lata Jayaraman, David K. Bol, Matthew Lorenzi
  • Rors as modifiers of the p21 pathway and methods of use
    Publication number: 20060101530
    Abstract: Human ROR genes are identified as modulators of the p21 pathway, and thus are therapeutic targets for disorders associated with defective p21 function. Methods for identifying modulators of p21, comprising screening for agents that modulate the activity of ROR are provided.
    Type: Application
    Filed: September 15, 2003
    Publication date: May 11, 2006
    Inventors: Helen Francis-Lang, Lori Friedman, Thomas Kidd, Siobhan Roche, Haiquang Zhang
  • Flj20647s as modifiers of the p21 pathway and methods of use
    Publication number: 20060063710
    Abstract: Human FLJ20647 genes are identified as modulators of the p21 pathway, and thus are therapeutic targets for disorders associated with defective p21 function. Methods for identifying modulators of p21, comprising screening for agents that modulate the activity of FLJ20647 are provided.
    Type: Application
    Filed: September 15, 2003
    Publication date: March 23, 2006
    Inventors: Helen Francis-Lang, Lori Friedman, Thomas Kidd, Siohan Roche, Kim Lickteig
  • PRMTs as modifiers of the p53 pathway and methods of use
    Publication number: 20060024665
    Abstract: Human PRMT genes are identified as modulators of the p53 pathway, and thus are therapeutic targets for disorders associated with defective p53 function. Methods for identifying modulators of p53, comprising screening for agents that modulate the activity of PRMT are provided.
    Type: Application
    Filed: September 30, 2005
    Publication date: February 2, 2006
    Inventors: Lori Friedman, Gregory Plowman, Marcia Belvin, Helen Francis-Lang, Danxi Li, Roel Funke, Rolf Ryseck, Lata Jayaraman, David Bol, Matthew Lorenzi
  • Slc2as as modifiers of the p53 pathway and methods of use
    Publication number: 20060024673
    Abstract: Human SLC2A genes are identified as modulators of the p53 pathway, and thus as therapeutic targets for disorders associated with defective p53 function. Methods for identifying modulators of p53, comprising screening for agents that modulate the activity of SLC2A are provided.
    Type: Application
    Filed: June 3, 2002
    Publication date: February 2, 2006
    Inventors: Lori Friedman, Gregory Plowman, Marcia Belvin, Helen Francis-Lang, Danxi Li, Roel Funke
  • RRP sequences and knockout mice and uses thereof
    Patent number: 6972179
    Abstract: RRP genes are identified as modulators of the p53 or p21 pathway, and thus are therapeutic targets for disorders associated with defective p53 or p21 function. Methods for identifying modulators of p53 or p21, comprising screening for agents that modulate the activity of RRP are provided. Modulating agents identified using the methods of the invention can be used to specifically inhibit growth of tumor cells that overexpress an RRP protein. mRRP1 knockout mice are also provided.
    Type: Grant
    Filed: January 23, 2002
    Date of Patent: December 6, 2005
    Assignee: Exelixis, Inc.
    Inventors: Lori Friedman, Marcia Belvin, Jeffrey S. Larson, Helen Francis-Lang, Gregory D. Plowman
  • Csnk1gs as modifiers of the p21 pathway and methods of use
    Publication number: 20050251870
    Abstract: Human CSNK1G genes are identified as modulators of the p21 pathway, and thus are therapeutic targets for disorders associated with defective p21 function. Methods for identifying modulators of p21, comprising screening for agents that modulate the activity of CSNK1G are provided.
    Type: Application
    Filed: August 6, 2003
    Publication date: November 10, 2005
    Applicant: Exelixis, Inc.
    Inventors: Helen Francis-Lang, Lori Friedman, Thomas Kidd
  • Map3ks as modifiers of the p53 pathway and methods of use
    Publication number: 20050227228
    Abstract: Human MAP3K genes are identified as modulators of the p53 pathway, and thus are therapeutic targets for disorders associated with defective p53 function. Methods for identifying modulators of p53, comprising screening for agents that modulate the activity of MAP3K are provided.
    Type: Application
    Filed: June 3, 2002
    Publication date: October 13, 2005
    Inventors: Lori Friedman, Gregory Plowman, Marcia Belvin, Helen Francis-Lang, Danxi Li, Roel Funke
  • PRMTs as modifiers of the p53 pathway and methods of use
    Publication number: 20050186566
    Abstract: Human PRMT genes are identified as modulators of the p53 pathway, and thus are therapeutic targets for disorders associated with defective p53 function. Methods for identifying modulators of p53, comprising screening for agents that modulate the activity of PRMT are provided.
    Type: Application
    Filed: June 5, 2002
    Publication date: August 25, 2005
    Inventors: Lori Friedman, Gregory Plowman, Marcia Belvin, Helen Francis-Lang, Danxi Li, Roel Funke, Rolf Ryseck, Lata Jayaraman, David Bol, Matthew Lorenzi
  • HADHs as modifiers of the p21 pathway and methods of use
    Publication number: 20050186200
    Abstract: Human HADH genes are identified as modulators of the p21 pathway, and thus are therapeutic targets for disorders associated with defective p21 function. Methods for identifying modulators of p21, comprising screening for agents that modulate the activity of HADH are provided.
    Type: Application
    Filed: April 11, 2005
    Publication date: August 25, 2005
    Inventors: Lori Friedman, Gregory Plowman, Roel Funke, Marcia Belvin, Danxi Li, Stephanie Robertson
  • HADHs as modifiers of the p21 pathway and methods of use
    Publication number: 20050181481
    Abstract: Human HADH genes are identified as modulators of the p21 pathway, and thus are therapeutic targets for disorders associated with defective p21 function. Methods for identifying modulators of p21, comprising screening for agents that modulate the activity of HADH are provided.
    Type: Application
    Filed: April 11, 2005
    Publication date: August 18, 2005
    Inventors: Lori Friedman, Gregory Plowman, Roel Funke, Marcia Belvin, Danxi Li, Stephanie Robertson
  • HADHs as modifiers of the p21 pathway and methods of use
    Patent number: 6927022
    Abstract: Human HADH genes are identified as modulators of the p21 pathway, and thus are therapeutic targets for disorders associated with defective p21 function. Methods for identifying modulators of p21, comprising screening for agents that modulate the activity of HADH are provided.
    Type: Grant
    Filed: July 10, 2002
    Date of Patent: August 9, 2005
    Assignee: Exelixis, Inc.
    Inventors: Lori Friedman, Gregory D. Plowman, Roel P. Funke, Marcia Belvin, Danxi Li, Stephanie A. Robertson
  • Chds as modifiers of the p53 pathway and methods of use
    Publication number: 20050170344
    Abstract: Human CHD genes are identified as modulators of the p53 pathway, and thus are therapeutic targets for disorders associated with defective p53 function. Methods for identifying modulators of p53, comprising screening for agents that modulate the activity of CHD are provided.
    Type: Application
    Filed: June 3, 2002
    Publication date: August 4, 2005
    Inventors: Lori Friedman, Gregory Plowman, Marcia Belvin, Helen Francis-Lang, Danxi Li, Roel Funke, Mario Lioubin