Patents by Inventor Lorin Thompson

Lorin Thompson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Hydroxyalkanoylaminolactams and related structures as inhibitors of A-beta protein production
    Publication number: 20030166636
    Abstract: This invention relates to novel lactams having the formula (I): 1
    Type: Application
    Filed: November 4, 2002
    Publication date: September 4, 2003
    Inventors: Richard E. Olson, Hong Liu, Lorin A. Thompson
  • Amino lactam sulfonamides as inhibitors of A-beta protein production
    Publication number: 20030130251
    Abstract: This invention relates to novel lactams having the Formula (I): 1
    Type: Application
    Filed: November 4, 2002
    Publication date: July 10, 2003
    Inventors: Lorin A. Thompson, Amy Qi Han
  • Succinoylamino heterocycles as inhibitors of a beta protein production
    Publication number: 20030073701
    Abstract: This invention relates to novel succinoylamino heterocycles having drug and bio-affecting properties, their pharmaceutical compositions and methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more specifically, inhibit the production of A&bgr;-peptide, thereby acting to prevent the formation of neurological deposits of amyloid protein. More particularly, the present invention relates to the treatment of neurological disorders related to &bgr;-amyloid production such as Alzheimer's disease and Down's Syndrome.
    Type: Application
    Filed: March 31, 2001
    Publication date: April 17, 2003
    Inventors: Lorin A. Thompson, Padmaja Kasireddy
  • Lactams as inhibitors of A-&bgr; protein production
    Patent number: 6495540
    Abstract: This invention relates to novel lactams having the Formula (I): to their pharmaceutical compositions and to their methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more specifically, inhibit the production of A&bgr;-peptide, thereby acting to prevent the formation of neurological deposits of amyloid protein. More particularly, the present invention relates to the treatment of neurological disorders related to &bgr;-amyloid production such as Alzheimer's disease and Down's Syndrome.
    Type: Grant
    Filed: March 27, 2001
    Date of Patent: December 17, 2002
    Assignee: Bristol - Myers Squibb Pharma Company
    Inventor: Lorin A. Thompson
  • Use of small molecule radioligands to discover inhibitors of amyloid-beta peptide production and for diagnostic imaging
    Publication number: 20020159947
    Abstract: This invention relates to a method of using radiolabelled and/or radiopharmaceutical small molecule inhibitors of beta-amyloid peptide production for the diagnosis of neurological and other disorders involving APP processing and beta-amyloid production. Furthermore, radiolabelled small molecule inhibitors identified by the methods of the present invention would be useful in the diagnosis of neurological disorders, such as Alzheimer's disease, which involve elevated levels of A&bgr; peptides.
    Type: Application
    Filed: May 17, 2001
    Publication date: October 31, 2002
    Inventors: Robert Zaczek, Richard E. Olson, Dietmar A. Seiffert, Lorin A. Thompson
  • Succinoylamino carbocycles and heterocycles as inhibitors of a-beta protein production
    Publication number: 20020055501
    Abstract: This invention relates to novel carbocycles and heterocycles having drug and bio-affecting properties, their pharmaceutical compositions and methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more specifically, inhibit the production of A&bgr;-peptide, thereby acting to prevent the formation of neurological deposits of amyloid protein. More particularly, the present invention relates to the treatment of neurological disorders related to &bgr;-amyloid production such as Alzheimer's disease and Down's Syndrome.
    Type: Application
    Filed: February 16, 2001
    Publication date: May 9, 2002
    Inventors: Richard E. Olson, Thomas P. Maduskuie, Lorin A. Thompson, Andrew J. Tebben, Nenghui Wang, Wei Deng, Hong Liu
  • Hydroxyalkanoylaminolactams and related structures as inhibitors of a beta protein production
    Publication number: 20020052360
    Abstract: This invention relates to novel lactams having the formula (I): 1
    Type: Application
    Filed: March 14, 2001
    Publication date: May 2, 2002
    Inventors: Richard E. Olson, Hong Liu, Lorin A. Thompson III
  • Lactams as inhibitors of A-beta protein production
    Publication number: 20020010172
    Abstract: This invention relates to novel lactams having the Formula (I): 1
    Type: Application
    Filed: March 27, 2001
    Publication date: January 24, 2002
    Inventor: Lorin A. Thompson