Patents by Inventor Lorinda D. Zigan

Lorinda D. Zigan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • High stability porous metal oxide spherules used for one-step antibody purifications
    Patent number: 6846410
    Abstract: The present invention describes the use of porous metal oxides for the preparative purification of antibodies and biomolecules within a range of particle physical characteristics. Typically, particles from 15 to 100 microns in average diameter with pores sizes ranging from 400 to 600 angstroms and surface areas from 10 to 50 square meters per gram, and pore volumes from 0.1 to 0.4 mL/gram can be used for purification processes. The metal oxide particles that fall within this range of physical properties show enhanced utility and greater chromatographic capacity for antibodies than materials oxide particles falling outside of this range. Metal oxides such as zirconia, titania and alumina can all be modified with a multi-Lewis base moiety such as an organophosphate ethylenediamine-N,N-tetra(methylenephosphonic) acid (EDTPA), to produce a bio-compatible purification media for, biomolecules.
    Type: Grant
    Filed: May 2, 2003
    Date of Patent: January 25, 2005
    Assignee: ZirChrom Separations, Inc.
    Inventors: Clayton V. McNeff, Peter W. Carr, Steven J. Rupp, Dwight R. Stoll, Danielle R. Hawker, Lorinda D. Zigan, Kerry G. Johnson
  • High stability porous metal oxide spherules used for one-step antibody purifications
    Publication number: 20040007530
    Abstract: The present invention describes the use of porous metal oxides for the preparative purification of antibodies and biomolecules within a range of particle physical characteristics. Typically, particles from 15 to 100 microns in average diameter with pores sizes ranging from 400 to 600 angstroms and surface areas from 10 to 50 square meters per gram, and pore volumes from 0.1 to 0.4 mL/gram can be used for purification processes. The metal oxide particles that fall within this range of physical properties show enhanced utility and greater chromatographic capacity for antibodies than materials oxide particles falling outside of this range. Metal oxides such as zirconia, titania and alumina can all be modified with a multi-Lewis base moiety such as an organophosphate ethylenediamine-N,N-tetra(methylenephosphonic) acid (EDTPA), to produce a bio-compatible purification media for, biomolecules.
    Type: Application
    Filed: May 2, 2003
    Publication date: January 15, 2004
    Inventors: Clayton V. McNeff, Peter W. Carr, Steven J. Rupp, Dwight R. Stoll, Danielle R. Hawker, Lorinda D. Zigan, Kerry G. Johnson