Patents by Inventor Loris MORETTI

Loris MORETTI has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOUNDS AS MODULATORS OF STAT6 AND USES THEREOF
    Publication number: 20260166047
    Abstract: Disclosed herein are compounds useful for the inhibition of STAT6. The compounds have a general Formula (I) or (II) or pharmaceutically acceptable salts thereof, wherein the variables of Formula (I) and (II) are as defined herein. Also provided herein are pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, diseases/disorders related to the activity of STAT6, such as an allergic disease or an inflammatory disease, including but not limited to atopic dermatitis or bronchial asthma. Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula (I) and (II).
    Type: Application
    Filed: December 16, 2025
    Publication date: June 18, 2026
    Applicant: AMGEN INC.
    Inventors: Liping H. PETTUS, Ana Sydelle BULGER, John Charles STELLWAGEN, Fabien EMMETIERE, Thomas FLAGSTAD, Emil GLIBSTRUP, Jeffrey JACKSON, Qingyian LIU, Quentin TERCENIO, Primali Vasundera NAVARATNE, Adriano BAUER, Slavko RAST, Andrew SMALIGO, Yujia TAO, Zhichen WU, Ningxin XU, John Gordon ALLEN, Dora TOLEDO WARSHAVIAK, Mona SHARAFI, Jason YU, Garrick Paul SMITH, Loris MORETTI, Visnja POLJAK, Adili ALAFATE, Matthew John COOK, Imelda Hot, David Huang, Jose Miguel MEDINA, Milauni Mehta UNDURTY, Cesar Nicolas PRIETO KULLMER, Hui-Ling WANG, Jingjing XIE, Nuria A. TAMAYO, Alexander James Pickrell, Minghao Wang, Wenhan Zhang
  • Indole derivatives as histone demethylase inhibitors
    Patent number: 10980777
    Abstract: The present application relates to compounds of formula (I), wherein A, R, R1, and R2 are as defined in the specification, pharmaceutical compositions containing such compounds and to their use in therapy.
    Type: Grant
    Filed: August 17, 2018
    Date of Patent: April 20, 2021
    Assignee: Istituto Europeo di Oncologia S.r.l.
    Inventors: Mario Varasi, Anna Cappa, Paola Vianello, Loris Moretti, Luca Sartori, Ciro Mercurio
  • INDOLE DERIVATIVES AS HISTONE DEMETHYLASE INHIBITORS
    Publication number: 20200289463
    Abstract: The present application relates to compounds of formula (I), wherein A, R, R1, and R2 are as defined in the specification, pharmaceutical compositions containing such compounds and to their use in therapy.
    Type: Application
    Filed: August 17, 2018
    Publication date: September 17, 2020
    Inventors: Mario VARASI, Anna CAPPA, Paola VIANELLO, Loris MORETTI, Luca SARTORI, Ciro MERCURIO
  • Thienopyrroles as histone demethylase inhibitors
    Patent number: 10183952
    Abstract: The present application relates to thienopyrrole derivatives, compounds of Formulas (I) and (Ia), wherein R, R1, R2 and R3 are as defined in the specification, pharmaceutical compositions containing such compounds and to their use in therapy. The compounds of the application can be useful for inhibiting KDM1 and the prevention and/or treatment of cancer, infectious disease, or a disease characterized by aberration of cellular energy metabolism, e.g., obesity.
    Type: Grant
    Filed: September 4, 2015
    Date of Patent: January 22, 2019
    Assignee: Istituto Europeo di Oncologia S.r.l.
    Inventors: Paola Vianello, Luca Sartori, Mario Varasi, Ciro Mercurio, Elisa Zagarri, Anna Cappa, Alessia Romussi, Manuela Villa, Giuseppe Meroni, Loris Moretti
  • THIENOPYRROLES AS HISTONE DEMETHYLASE INHIBITORS
    Publication number: 20170260197
    Abstract: The present application relates to thienopyrrole derivatives, compounds of Formulas (I) and (Ia), wherein R, R1, R2 and R3 are as defined in the specification, pharmaceutical compositions containing such compounds and to their use in therapy. The compounds of the application can be useful for inhibiting KDM1 and the prevention and/or treatment of cancer, infectious disease, or a disease characterized by aberration of cellular energy metabolism, e.g., obesity.
    Type: Application
    Filed: September 4, 2015
    Publication date: September 14, 2017
    Inventors: Paola VIANELLO, Luca SARTORI, Mario VARASI, Ciro MERCURIO, Elisa ZAGARRI, Anna CAPPA, Alessia ROMUSSI, Manuela VILLA, Giuseppe MERONI, Loris MORETTI