Abstract: The disclosure relates to modulating pyruvate kinase and provides novel chemical compounds useful as activators of PKR, as well as various uses of these compounds. PKR activating compounds are useful in the treatment of diseases and disorders associated with PKR and/or PKM2, such as pyruvate kinase deficiency (PKD), sickle cell disease (SCD), and thalassemia.

Abstract: A partitioned structure comprising an open topped container and a plurality of dividers having sides positioned within the container. The container has horizontal interior side channels on either side thereof so that each divider having at least one tab disposed on each side thereof slides within one of the horizontal channels and permits movement of the divider relative to the container. Each divider has a projection extending above its top on which information is placed.