Patents by Inventor Lorna Duffy

Lorna Duffy has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • QUATERNARY INDAZOLE GLUCOCORTICOID RECEPTOR ANTAGONISTS
    Publication number: 20240150320
    Abstract: The present disclosure provides compounds of Formula I or II. Compounds of Formula I or II may be used in pharmaceutical formulations, and may be used for modulating glucocorticoid receptors.
    Type: Application
    Filed: August 11, 2023
    Publication date: May 9, 2024
    Inventors: Hazel Hunt, Lorna DUFFY, Ian STRUTT, Morgan JOUANNEAU, Thomas HORNSBY, Mark MILLS, Andrew William PHILLIPS, Jon-Paul WARD
  • Aminothiazole Compounds as Inhibitors of CTPS1
    Publication number: 20240010645
    Abstract: Compounds of formula (I): (I) and related aspects.
    Type: Application
    Filed: April 18, 2023
    Publication date: January 11, 2024
    Inventors: Abdul QUDDUS, Andrew NOVAK, David COUSIN, Elli CHATZOPOULOU, Emma BLACKHAM, Geraint JONES, Jennifer THOMAS, Joesph WRIGGLESWORTH, Lorna DUFFY, Louise BIRCH, Pascal GEORGE, Saleh AHMED
  • Quaternary indazole glucocorticoid receptor antagonists
    Patent number: 11787780
    Abstract: The present disclosure provides compounds of Formula I or II. Compounds of Formula I or II may be used in pharmaceutical formulations, and may be used for modulating glucocorticoid receptors.
    Type: Grant
    Filed: June 21, 2021
    Date of Patent: October 17, 2023
    Assignee: Corcept Therapeutics Incorporated
    Inventors: Hazel Hunt, Lorna Duffy, Ian Strutt, Morgan Jouanneau, Thomas Hornsby, Mark Mills, Andrew William Phillips, Jon-Paul Ward
  • BICYCLIC INDAZOLE GLUCOCORTICOID RECEPTOR ANTAGONISTS
    Publication number: 20230242514
    Abstract: The present disclosure provides compounds of Formula I, Ia, Ib, Ib-1, Ib-2, Ic, Ic-1, Id-1, and Id-2. Compounds of Formula I, Ia, Ib, Ib-1, Ib-2, Ic, Ic-1, Id-1, and Id-2 may be used in pharmaceutical formulations, and may be used for modulating glucocorticoid receptors.
    Type: Application
    Filed: December 20, 2022
    Publication date: August 3, 2023
    Inventors: Lorna Duffy, Thomas Hornsby, Morgan Jouanneau, Mark Mills, Andrew William Phillips, Andrew James Smith, Hazel Joan Hunt, Peter Hunt
  • Compounds
    Publication number: 20230192673
    Abstract: Compounds of formula (I): and related aspects.
    Type: Application
    Filed: November 3, 2022
    Publication date: June 22, 2023
    Inventors: Abdul Quddus, Andrew Novak, David Cousin, Emma Blackham, Geraint Jones, Joseph Wrigglesworth, Lorna Duffy, Louise Birch, Pascal George, Saleh Ahmed
  • Compounds
    Publication number: 20230183229
    Abstract: Compounds of formula (I) and related aspects.
    Type: Application
    Filed: October 10, 2022
    Publication date: June 15, 2023
    Inventors: Andrew NOVAK, Geraint JONES, Joseph WRIGGLESWORTH, Lorna DUFFY, Louise BIRCH, Pascal George
  • PYRIMIDINE CYCLOHEXENYL GLUCOCORTICOID RECEPTOR MODULATORS
    Publication number: 20230183186
    Abstract: The present invention provides a class of pyrimidinedione cyclohekenyl compounds and methods of using these compounds as glucocorticoid receptor modulators.
    Type: Application
    Filed: November 16, 2022
    Publication date: June 15, 2023
    Inventors: Hazel Hunt, Damien Francis Philippe Crepin, Joseph Thomas Hill-Cousins, Thomas Matthew Baker, Lorna Duffy
  • Aminothiazole compounds as inhibitors of CTPS1
    Patent number: 11655246
    Abstract: Compounds of formula (I): (I) and related aspects.
    Type: Grant
    Filed: November 30, 2018
    Date of Patent: May 23, 2023
    Assignee: STEP PHARMA S.A.S.
    Inventors: Abdul Quddus, Andrew Novak, David Cousin, Elli Chatzopoulou, Emma Blackham, Geraint Jones, Jennifer Thomas, Joseph Wrigglesworth, Lorna Duffy, Louise Birch, Pascal George, Saleh Ahmed
  • N-(4-(5-chloropyridin-3-yl)phenyl)-2-(2-(cyclopropanesulfonamido)pyrimidin-4-yl) butanamide derivatives and related compounds as human CTPS1 inhibitors for the treatment of proliferative diseases
    Publication number: 20230086703
    Abstract: Compounds of formula (I) wherein ring B is selected from the group consisting of Formula (B-a) and Formula (B-bc) as human cytidine triphosphate synthase 1 (CTPS 1) inhibitors for the treatment of proliferative diseases, such as e.g. cancer, such as e.g. leukemia and lymphoma, e.g. inflammatory skin diseases such as psoriasis, or e.g. multiple sclerosis. The present description discloses the synthesis and characterisation of exemplary compounds as well as pharmacological data thereof (e.g. page 129 to page 302; examples; biological examples 1 and 2; tables 1-17). Specific examples are e.g.: N-(4-(5-Chloropyridin-3-yl)phenyl)-2-(2-(cyclopropane-sulfonamido) pyrimidin-4-yl)butanamide (Formula P1) or 1-(2-(Cyclopropanesulfonamido)pyrimidin-4-yl)-N-(4-(6-ethoxypyrazin-2-yl)phenyl)cyclopentanecarboxamide (Formula P2).
    Type: Application
    Filed: June 4, 2020
    Publication date: March 23, 2023
    Applicant: Step Pharma S.A.S.
    Inventors: Abdul Quddus, Andrew Novak, David Cousin, Emma Blackham, Ellie Chatzopoulou, Geraint Jones, Jennifer Thomas, Joseph Wrigglesworth, Lorna Duffy, Louise Birch, Pascal George, Saleh Ahmed, Gianna Toschi
  • QUATERNARY INDAZOLE GLUCOCORTICOID RECEPTOR ANTAGONISTS
    Publication number: 20230032612
    Abstract: The present disclosure provides compounds of Formula I or II. Compounds of Formula I or II may be used in pharmaceutical formulations, and may be used for modulating glucocorticoid receptors.
    Type: Application
    Filed: June 21, 2021
    Publication date: February 2, 2023
    Inventors: Hazel Hunt, Lorna DUFFY, Ian STRUTT, Morgan JOUANNEAU, Thomas HORNSBY, Mark MILLS, Andrew William PHILLIPS, Jon-Paul WARD
  • SULFONAMIDE INHIBITORS AS CTPS1 INHIBITORS
    Publication number: 20230020663
    Abstract: The invention provides a compound of formula (I) and processes for the manufacture of such compounds, related intermediates, compositions comprising such compounds and the use of such compounds as cytidine triphosphate synthase 1 inhibitors, particularly in the treatment or prophylaxis of disorders associated with cell proliferation.
    Type: Application
    Filed: September 18, 2020
    Publication date: January 19, 2023
    Applicant: Step Pharma S.A.S.
    Inventors: Andrew Novak, Abdul Quddus, David Cousin, Joseph Wrigglesworth, Emma Blackham, Geraint Jones, Lorna Duffy, Louise Birch, Pascal George, Saleh Ahmed
  • SULFONAMIDE DERIVATIVES AS CTPS1 INHIBITORS
    Publication number: 20230002352
    Abstract: The invention provides a compound of formula (I): formula (I) and the use of such compounds as cytidine triphosphate synthase 1 inhibitors, particularly in the treatment or prophylaxis of disorders associated with cell proliferation.
    Type: Application
    Filed: September 18, 2020
    Publication date: January 5, 2023
    Applicant: Step Pharma S.A.S.
    Inventors: Andrew Novak, Abdul Quddus, David Cousin, Joseph Wrigglesworth, Emma Blackham, Geraint Jones, Lorna Duffy, Louise Birch, Pascal George, Saleh Ahmed
  • Pyrimidine cyclohexenyl glucocorticoid receptor modulators
    Patent number: 11542238
    Abstract: The present invention provides a class of pyrimidinedione cyclohexenyl compounds and methods of using these compounds as glucocorticoid receptor modulators.
    Type: Grant
    Filed: June 3, 2019
    Date of Patent: January 3, 2023
    Assignee: Corcept Therapeutics Incorporated
    Inventors: Hazel Hunt, Damien Francis Philippe Crepin, Joseph Thomas Hill-Cousins, Thomas Matthew Baker, Lorna Duffy
  • Compounds
    Patent number: 11505547
    Abstract: Compounds of formula (I) and related aspects.
    Type: Grant
    Filed: November 30, 2018
    Date of Patent: November 22, 2022
    Assignee: STEP PHARMA S.A.S.
    Inventors: Andrew Novak, Geraint Jones, Joseph Wrigglesworth, Lorna Duffy, Louise Birch, Pascal George
  • ADO-resistant cysteamine analogs and uses thereof
    Patent number: 11505550
    Abstract: The present disclosure is directed to methods for treating diseases for which cysteamine is indicated and compounds useful in such methods.
    Type: Grant
    Filed: February 1, 2021
    Date of Patent: November 22, 2022
    Assignee: HORIZON ORPHAN LLC
    Inventors: Todd C. Zankel, John Unitt, Timothy Phillips, Benoit Gourdet, Lorna Duffy
  • N-(5-(6-ethoxypyrazin-2-yl)pyridin-2-yl)-4-(2-(methylsulfonamido)pyrimidin-4-yl) tetrahydro-2H-pyran-4-carboxamide derivatives and related compounds as human CTPS1 inhibitors for the treatment of proliferative diseases
    Publication number: 20220324837
    Abstract: Compounds of formula (I) as human cytidine triphosphate synthase 1 (CTPS1) inhibitors for the treatment of prolifera-tive diseases, such as e.g. cancer, such as e.g. leukemia and lymphoma, e.g. inflammatory skin diseases such as psoriasis, or e.g. multiple sclerosis. The present description discloses the synthesis and characterisa-tion of exemplary compounds as well as pharmacological data thereof (e.g. pages 64 to 80; examples; biological examples 1 and 2; e.g. compounds P140, P231 to P263; tables 1 to 10). Specific examples are e.g.: N-(5-(6-ethoxypyrazin-2-yl)pyridin-2-yl)-4-(2-(methylsulfonami-N do) pyrimidin-4-yl)tetrahydro-2H-pyran-4-carboxamide (Formula (II)), or 1-(2-(cyclopropanesulfonamido)pyrimidin-4-yl)-N-(5-(6-ethoxypyrazin-2-yl)pyridin-2-yl)cyclohexane-1-carboxamide (Formula (III)).
    Type: Application
    Filed: June 4, 2020
    Publication date: October 13, 2022
    Applicant: Step Pharma S.A.S.
    Inventors: Abdul Quddus, Andrew Novak, David Cousin, Emma Blackham, Geraint Jones, Joseph Wrigglesworth, Lorna Duffy, Louise Birch, Pascal George, Saleh Ahmed
  • ADO-RESISTANT CYSTEAMINE ANALOGS AND USES THEREOF
    Publication number: 20220024920
    Abstract: The present disclosure is directed to methods for treating diseases for which cysteamine is indicated and compounds useful in such methods.
    Type: Application
    Filed: February 1, 2021
    Publication date: January 27, 2022
    Inventors: Todd C. Zankel, John Unitt, Timothy Phillips, Benoit Gourdet, Lorna Duffy
  • Compounds
    Publication number: 20210387965
    Abstract: Compounds of formula (I), and related aspects.
    Type: Application
    Filed: October 23, 2019
    Publication date: December 16, 2021
    Applicant: Step Pharma S.A.S.
    Inventors: Abdul Quddus, Andrew Novak, David Cousin, Emma Blackham, Geraint Jones, Joseph Wrigglesworth, Lorna Duffy, Louise Birch, Pascal George, Saleh Ahmed
  • COMPOUNDS
    Publication number: 20210380575
    Abstract: Compounds of formula (I) and related aspects.
    Type: Application
    Filed: November 30, 2018
    Publication date: December 9, 2021
    Inventors: Andrew NOVAK, Geraint JONES, Joseph WRIGGLESWORTH, Lorna DUFFY, Louise BIRCH, Pascal GEORGE
  • PYRIMIDINE CYCLOHEXENYL GLUCOCORTICOID RECEPTOR MODULATORS
    Publication number: 20210238148
    Abstract: The present invention provides a class of pyrimidinedione cyclohekenyl compounds and methods of using these compounds as glucocorticoid receptor modulators.
    Type: Application
    Filed: June 3, 2019
    Publication date: August 5, 2021
    Inventors: Hazel HUNT, Damien Francis Philippe CREPIN, Joseph Thomas HILL-COUSINS, Thomas Matthew BAKER, Lorna DUFFY