Patents by Inventor Lorna W. Role

Lorna W. Role has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • A-form of cytoplasmic domain of nARIA (CRD-neuregulin) and uses thereof
    Patent number: 6933122
    Abstract: This invention provides nARIA-based assays for defining whether a subject has or is predisposed to developing a neoplastic disease. This invention further provides a nARIA-based method for maintaining synaptic connections between a neuron and a target cell.
    Type: Grant
    Filed: May 14, 1999
    Date of Patent: August 23, 2005
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Lorna W. Role, David Talmage, Jianxin Bao
  • Splice variants of the heregulin gene, nARIA and uses thereof
    Patent number: 6284535
    Abstract: This invention provides an isolated nucleic acid molecule encoding an nARIA polypeptide, including human nARIA (hnARIA) and chicken nARIA (cnARIA). These nucleic acid molecules may be DNA, cDNA, or RNA. This invention also provides for a purified nARIA polypeptide. This invention provides for a replicable vector comprising an nARIA sequence and host cells comprising this vector. This invention provides for a composition comprising the nARIA polypeptide and a pharmaceutically acceptable carrier. One embodiment of this invention is a method for inducing the formation of a synaptic junction between a neuron and a target cell comprising contacting the target cell with an nARIA polypeptide or a nucleic acid molecule encoding nARIA in an amount sufficient to induce the formation of a synaptic junction.
    Type: Grant
    Filed: September 4, 1996
    Date of Patent: September 4, 2001
    Assignee: The Trustees of Columbia University in the City of New York
    Inventor: Lorna W. Role