Patents by Inventor Lorne A. Clarke

Lorne A. Clarke has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Mucopolysaccharidosis (MPS) diagnostic methods, systems, kits and assays associated therewith
    Patent number: 8105788
    Abstract: Methods, systems, kits and assays for diagnosing, monitoring or screening for mucopolysaccharidosis (MPS) and methods and systems for assaying test compounds for therapeutic activity are described, whereby MPS marker protein levels are assayed as an indication of MPS.
    Type: Grant
    Filed: December 8, 2006
    Date of Patent: January 31, 2012
    Assignee: The University of British Columbia
    Inventors: Lorne A. Clarke, Derrick Raymond Randall, Graham Sinclair
  • MUCOPOLYSACCHARIDOSIS (MPS) DIAGNOSTIC METHODS, SYSTEMS, KITS AND ASSAYS ASSOCIATED THEREWITH
    Publication number: 20090092996
    Abstract: Methods, systems, kits and assays for diagnosing, monitoring or screening for mucopolysaccharidosis (MPS) and methods and systems for assaying test compounds for therapeutic activity are described, whereby MPS marker protein levels are assayed as an indication of MPS.
    Type: Application
    Filed: December 8, 2006
    Publication date: April 9, 2009
    Inventors: Lorne A. Clarke, Derrick Raymond Randall, Graham Sinclair
  • Production Of A Protein Localized To The Endoplasmic Reticulum Protein Bodies In A Transgenic Plant And Seed
    Publication number: 20080034455
    Abstract: A nucleotide sequence is provided for expression of a heterologous protein of interest that is localized to the endoplasmic reticulum protein bodies in transgenic plants, plant cells, and seeds. Said nucleotide sequence comprises a promoter, the 5? untranslated region from the maize ?-zein gene, the ?-zein signal peptide sequence, a sequence encoding a heterologous protein of interest, and the 3? untranslated region from the maize ?-zein gene, operatively linked.
    Type: Application
    Filed: May 19, 2005
    Publication date: February 7, 2008
    Applicant: SIMON FRASER UNIVERSITY
    Inventors: Allison Kermode, Xu He, Lorne Clarke
  • Transgenic mouse model for iduronidase deficiency and methods of making and using same
    Patent number: 6002067
    Abstract: A mouse which is homozygous for a disruption in the IDUA gene, but which has normal expression for the SAT-1 gene can be used for evaluating therapeutic agents for use in treating mucopolysaccharidosis Type I, by administering the therapeutic agent to the mouse, and evaluating the mouse for tissue pathology associated with iduronidase deficiency. The mouse can also be used for evaluating the ability of a targeting system to deliver a therapeutic agent to selected tissues or organs by administering an effective iduronidase replacement therapy coupled to the targeting system to a mouse which is homozygous for a disruption in the IDUA gene, but which has normal expression for the SAT-1 gene; and evaluating at least the selected tissue or organ from the mouse for pathology associated with iduronidase deficiency. Targeting systems which can be evaluated using this methodology include targeting moieties which selectively bind to or associate with selected cell types and in vivo and ex vivo gene therapy systems.
    Type: Grant
    Filed: May 20, 1997
    Date of Patent: December 14, 1999
    Assignee: The University of British Columbia
    Inventors: Lorne A. Clarke, Frank Jirik