Patents by Inventor Lorne Golub

Lorne Golub has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CURCUMIN ANALOGUES AS ZINC CHELATORS AND THEIR USES
    Publication number: 20240360068
    Abstract: This invention provides a compound having the structure wherein ?, ?, X, Y, and R1-R11 are defined herein. This invention also provides a pharmaceutical composition comprising the above compounds, a method of inhibiting the activity and/or levels of a matrix metalloproteinase (MMP), a method of inhibiting the production of a cytokine in a population of cells, a method of inhibiting the production of a growth factor in a population of cells, and a method of inhibiting NF?-B activation in a population of cells.
    Type: Application
    Filed: July 11, 2024
    Publication date: October 31, 2024
    Applicants: The Research Foundation for the State University of New York, Chem-Master International, Inc.
    Inventors: Francis Johnson, Lorne Golub
  • Curcumin analogues as zinc chelators and their uses
    Patent number: 11608309
    Abstract: This invention provides a compound having the structure wherein ?, ?, X, Y, and R1-R11 are defined herein. This invention also provides a pharmaceutical composition comprising the above compounds, a method of inhibiting the activity and/or levels of a matrix metalloproteinase (MMP), a method of inhibiting the production of a cytokine in a population of cells, a method of inhibiting the production of a growth factor in a population of cells, and a method of inhibiting NF?-B activation in a population of cells.
    Type: Grant
    Filed: May 28, 2020
    Date of Patent: March 21, 2023
    Assignees: THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, CHEM-MASTER INTERNATIONAL INC.
    Inventors: Francis Johnson, Lorne Golub
  • CURCUMIN ANALOGUES AS ZINC CHELATORS AND THEIR USES
    Publication number: 20210053905
    Abstract: This invention provides a compound having the structure wherein ?, ?, X, Y, and R1-R11 are defined herein. This invention also provides a pharmaceutical composition comprising the above compounds, a method of inhibiting the activity and/or levels of a matrix metalloproteinase (MMP), a method of inhibiting the production of a cytokine in a population of cells, a method of inhibiting the production of a growth factor in a population of cells, and a method of inhibiting NF?-B activation in a population of cells.
    Type: Application
    Filed: May 28, 2020
    Publication date: February 25, 2021
    Applicants: THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK, CHEM-MASTER INTERNATIONAL, INC.
    Inventors: Francis Johnson, Lorne Golub
  • Curcumin analogues as zinc chelators and their uses
    Patent number: 10669227
    Abstract: This invention provides a compound having the structure wherein ?, ?, X, Y, and R1-R11 are defined herein. This invention also provides a pharmaceutical composition comprising the above compounds, a method of inhibiting the activity and/or levels of a matrix metalloproteinase (MMP), a method of inhibiting the production of a cytokine in a population of cells, a method of inhibiting the production of a growth factor in a population of cells, and a method of inhibiting NF?-B activation in a population of cells.
    Type: Grant
    Filed: December 19, 2016
    Date of Patent: June 2, 2020
    Assignee: THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK
    Inventors: Francis Johnson, Lorne Golub
  • CURCUMIN ANALOGUES AS ZINC CHELATORS AND THEIR USES
    Publication number: 20170158605
    Abstract: This invention provides a compound having the structure wherein ?, ?, X, Y, and R1-R11 are defined herein. This invention also provides a pharmaceutical composition comprising the above compounds, a method of inhibiting the activity and/or levels of a matrix metalloproteinase (MMP), a method of inhibiting the production of a cytokine in a population of cells, a method of inhibiting the production of a growth factor in a population of cells, and a method of inhibiting NF?-B activation in a population of cells.
    Type: Application
    Filed: December 19, 2016
    Publication date: June 8, 2017
    Applicants: THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK, CHEM-MASTER INTERNATIONAL, INC.
    Inventors: Francis Johnson, Lorne Golub
  • Curcumin analogues as zinc chelators and their uses
    Patent number: 9556105
    Abstract: This invention provides a compound having the structure wherein ?, ?, X, Y, and R1-R11 are defined herein. This invention also provides a pharmaceutical composition comprising the above compounds, a method of inhibiting the activity and/or levels of a matrix metalloproteinase (MMP), a method of inhibiting the production of a cytokine in a population of cells, a method of inhibiting the production of a growth factor in a population of cells, and a method of inhibiting NF?-B activation in a population of cells.
    Type: Grant
    Filed: October 14, 2015
    Date of Patent: January 31, 2017
    Assignees: THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK, CHEM-MASTER INTERNATIONAL, INC.
    Inventors: Francis Johnson, Lorne Golub
  • CURCUMIN ANALOGUES AS ZINC CHELATORS AND THEIR USES
    Publication number: 20160031795
    Abstract: This invention provides a compound having the structure wherein ?, ?, X, Y, and R1-R11 are defined herein. This invention also provides a pharmaceutical composition comprising the above compounds, a method of inhibiting the activity and/or levels of a matrix metalloproteinase (MMP), a method of inhibiting the production of a cytokine in a population of cells, a method of inhibiting the production of a growth factor in a population of cells, and a method of inhibiting NF?-B activation in a population of cells.
    Type: Application
    Filed: October 14, 2015
    Publication date: February 4, 2016
    Applicants: THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK, CHEM-MASTER INTERNATIONAL, INC.
    Inventors: FRANCIS JOHNSON, LORNE GOLUB
  • Curcumin analogues as zinc chelators and their uses
    Patent number: 9187406
    Abstract: This invention provides a compound having the structure wherein ?, ?, X, Y, and R1-R11 are defined herein. This invention also provides a pharmaceutical composition comprising the above compounds, a method of inhibiting the activity and/or levels of a matrix metalloproteinase (MMP), a method of inhibiting the production of a cytokine in a population of cells, a method of inhibiting the production of a growth factor in a population of cells, and a method of inhibiting NF?-B activation in a population of cells.
    Type: Grant
    Filed: May 14, 2010
    Date of Patent: November 17, 2015
    Assignees: The Research Foundation of State University of New York, Chem-Master International, Inc.
    Inventors: Francis Johnson, Lorne Golub
  • SYSTEM AND METHOD FOR DIFFERENTIALLY TIMED LOCAL DELIVERY OF A COMBINATION PHARMACEUTICAL PREPARATION FOR ORAL THERAPY
    Publication number: 20140205662
    Abstract: The present invention is directed to a system and method for treating oral diseases in a subject. This method comprises the following steps; diagnosing the subject, and choosing one or a combination of medications, their dosing and desired time course and then delivering the medications to the desired site in the periodontal pocket by administering a plurality of microcapsules, capsules, the microcapsules comprising one or more pharmaceutical agent(s) that are released in a predetermined manner and in accordance with the pathophysiology of the targeted disease.
    Type: Application
    Filed: November 3, 2011
    Publication date: July 24, 2014
    Applicant: The Research Foundation for The State University of New York
    Inventors: Steven P. Engebretson, Nathan Blumberg, Lorne Golub
  • CURCUMIN ANALOGUES AS ZINC CHELATORS AND THEIR USES
    Publication number: 20120095051
    Abstract: This invention provides a compound having the structure wherein ?, ?, X, Y, and R1-R11 are defined herein. This invention also provides a pharmaceutical composition comprising the above compounds, a method of inhibiting the activity and/or levels of a matrix metalloproteinase (MMP), a method of inhibiting the production of a cytokine in a population of cells, a method of inhibiting the production of a growth factor in a population of cells, and a method of inhibiting NF?-B activation in a population of cells.
    Type: Application
    Filed: May 14, 2010
    Publication date: April 19, 2012
    Inventors: Francis Johnson, Lorne Golub
  • Use of non-antibacterial tetracycline formulations for inhibiting bacterial spores from becoming infectious vegetative cells
    Publication number: 20070015738
    Abstract: The invention relates to a method for inhibiting bacterial spores from becoming infectious vegetative cells in a mammal in need thereof. The method comprises administering to the mammal an effective amount of a non-antibacterial tetracycline formulation. In one embodiment, the non-antibacterial tetracycline formulation comprises an antibacterial tetracycline in a sub-antibacterial amount. In another embodiment, the non-antibacterial tetracycline formulation comprises a non-antibacterial tetracycline.
    Type: Application
    Filed: July 15, 2005
    Publication date: January 18, 2007
    Inventors: Stephen Walker, Lorne Golub, Sanford Simon
  • Use of non-antibacterial tetracycline formulations for inhibiting bacterial spores
    Publication number: 20070015739
    Abstract: The invention relates to a method for inhibiting bacterial spores from becoming infectious vegetative cells in a mammal in need thereof. In another embodiment, invention relates to a method for inhibiting outgrowth of bacterial spores in a mammal in need thereof. The method comprises administering to the mammal an effective amount of a non-antibacterial tetracycline formulation. In one embodiment, the non-antibacterial tetracycline formulation comprises an antibacterial tetracycline in a sub-antibacterial amount. In another embodiment, the non-antibacterial tetracycline formulation comprises a non-antibacterial tetracycline.
    Type: Application
    Filed: December 23, 2005
    Publication date: January 18, 2007
    Inventors: Stephen Walker, Lorne Golub, Sanford Simon
  • Method for reducing c-rective protein levels with non-antibacterial tetracycline formulations
    Publication number: 20050282786
    Abstract: The present invention is for a method for decreasing C-reactive protein levels (CRP) in a mammal in need thereof. The method comprises administering an effective amount of a non-antibacterial tetracycline formulation, to the mammal. In one embodiment, the non-antibacterial tetracycline formulation is a non-antibacterial amount of an antibacterial tetracycline. In another embodiment, the non-antibacterial tetracycline formulation is a non-antibacterial tetracycline.
    Type: Application
    Filed: July 11, 2003
    Publication date: December 22, 2005
    Inventors: David Brown, Lorne Golub, Hsi-Ming Lee, Robert Greenwald
  • Methods of treating eczema
    Publication number: 20050148552
    Abstract: A method of treating eczema in a human or other mammal in need thereof comprising administering systemically to said human or other mammal a tetracycline compound in an amount that is effective to treat eczema, but has substantially no antibacterial activity.
    Type: Application
    Filed: November 5, 2004
    Publication date: July 7, 2005
    Inventors: Maria Ryan, Yu Liu, Lorne Golub, Hsi-Ming Lee, Sanford Simon, Stephen Walker