Patents by Inventor Lorne R. Palmer

Lorne R. Palmer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cationic peg-lipids and methods of use
    Publication number: 20040241855
    Abstract: The present invention provides cationic-polymer-lipid conjugates (CPLs) such as distal cationic-poly(ethylene glycol)-lipid conjugates which can be incorporated into conventional and stealth liposomes or other lipid-based formulation for enhancing cellular uptake. The CPLs of the present invention comprise a lipid moiety; a hydrophilic polymer; and a polycationic moiety. Method of increasing intracellular delivery of nucleic acids are also provided.
    Type: Application
    Filed: July 2, 2004
    Publication date: December 2, 2004
    Applicant: The University of British Columbia
    Inventors: Pieter R. Cullis, Tao Chen, David B. Fenske, Lorne R. Palmer, Kim Wong
  • Liposomal apparatus and manufacturing methods
    Publication number: 20040142025
    Abstract: The present invention provides apparatus and processes for producing liposomes. By providing a buffer solution in a first reservoir, and a lipid solution in a second reservoir, continuously diluting the lipid solution with the buffer solution in a mixing chamber produces a liposome. The lipid solution preferably comprises an organic solvent, such as a lower alkanol.
    Type: Application
    Filed: June 30, 2003
    Publication date: July 22, 2004
    Applicant: Protiva Biotherapeutics Ltd.
    Inventors: Ian MacLachlan, Lloyd Jeffs, Lorne R. Palmer, Cory Giesbrecht, Noelle Giesbrecht
  • Methods of enhancing SPLP-mediated transfection using endosomal membrane destabilizers
    Publication number: 20020072121
    Abstract: The present invention provides novel and surprisingly effective methods for delivering nucleic acids to cells. These methods are based upon the discovery that the presence of endosomal membrane destabilizers (e.g., calcium) leads to a dramatic increase in the transfection efficiency of plasmids formulated as SPLP, or “stabilized plasmid-lipid particles.
    Type: Application
    Filed: April 20, 2001
    Publication date: June 13, 2002
    Inventors: Angela M.I. Lam, Lorne R. Palmer, Pieter R. Cullis