Patents by Inventor Lorraine E. Reeve

Lorraine E. Reeve has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 6977045
    Abstract: A process for the purification or fractionation of aqueous soluble polymers using an aqueous two-phase system is described. The concentrations of the polymer to be fractionated and of an aqueous soluble salt, and the temperature of the aqueous fractionation medium are adjusted so that two phases form, the lower molecular weight polymer molecules partition into the high salt concentration phase, and the higher molecular weight polymer molecules partition into the low salt concentration phase. The resulting high molecular weight polymers are characterized by a higher average molecular weight and a narrower molecular weight distribution and decreased unsaturation than the unfractionated polymers. After being subjected to the fractionation process, polyol polymers that form hydrogels in aqueous solution exhibited higher viscosities and a liquid to gel transition over a narrower temperature range than the unfractionated polyol polymers.
    Type: Grant
    Filed: January 28, 2004
    Date of Patent: December 20, 2005
    Assignee: Pluromed, Inc.
    Inventors: Lorraine E. Reeve, Michael G. Hinsberg
  • Publication number: 20040266983
    Abstract: The present invention relates to fractionated block copolymers characterized by a higher average molecular weight, a narrower molecular weight distribution and decreased unsaturation compared to the unfractionated polymers. The polyoxyalkylene block copolymers exhibited higher viscosities, a liquid to gel transition at lower temperatures and a liquid to gel transition over a narrower temperature range than unfractionated polyoxyalkylene block copolymers at the same concentration. One specific aspect of the invention relates to a polyoxyalkylene block copolymer, wherein the polyoxyalkylene block copolymer transforms from a liquid to a gel over a temperature range of about 2° C. to about 5° C. Another specific aspect relates to a polyoxyalkylene block copolymer, wherein the viscosity of an aqueous solution of the polyoxyalkylene block copolymer increases by at least a factor of two over a temperature range of about 2° C.
    Type: Application
    Filed: March 26, 2004
    Publication date: December 30, 2004
    Inventors: Lorraine E. Reeve, Michael G. Hinsberg
  • Publication number: 20040222155
    Abstract: A process for the purification or fractionation of aqueous soluble polymers using an aqueous two-phase system is described. The concentrations of the polymer to be fractionated and of an aqueous soluble salt, and the temperature of the aqueous fractionation medium are adjusted so that two phases form, the lower molecular weight polymer molecules partition into the high salt concentration phase, and the higher molecular weight polymer molecules partition into the low salt concentration phase. The resulting high molecular weight polymers are characterized by a higher average molecular weight and a narrower molecular weight distribution and decreased unsaturation than the unfractionated polymers. After being subjected to the fractionation process, polyol polymers that form hydrogels in aqueous solution exhibited higher viscosities and a liquid to gel transition over a narrower temperature range than the unfractionated polyol polymers.
    Type: Application
    Filed: January 28, 2004
    Publication date: November 11, 2004
    Inventors: Lorraine E. Reeve, Michael G. Hinsberg
  • Patent number: 6761824
    Abstract: A process for the purification or fractionation of aqueous soluble polymers using an aqueous two-phase system is described. The concentrations of the polymer to be fractionated and of an aqueous soluble salt, and the temperature of the aqueous fractionation medium are adjusted so that two phases form, the lower molecular weight polymer molecules partition into the high salt concentration phase, and the higher molecular weight polymer molecules partition into the low salt concentration phase. The resulting high molecular weight polymers are characterized by a higher average molecular weight and a narrower molecular weight distribution and decreased unsaturation than the unfractionated polymers. After being subjected to the fractionation process, polyol polymers that form hydrogels in aqueous solution exhibited higher viscosities and a liquid to gel transition over a narrower temperature range than the unfractionated polyol polymers.
    Type: Grant
    Filed: August 13, 2001
    Date of Patent: July 13, 2004
    Inventors: Lorraine E. Reeve, Michael G. Hinsberg
  • Publication number: 20040073206
    Abstract: Methods are provided to assist a surgeon in ablating conduction paths in tissue, such as a heart. In one embodiment, the invention presents a method that includes placing a guide in contact with the tissue to be ablated, applying an ablation probe to the tissue using the guide to assist in control of movement of the ablation probe, measuring the effectiveness of the ablation probe in ablation of the conduction paths, and deactivating the ablation probe when the measured effectiveness meets a desired level. Placement of the guide in contact with the tissue allows the surgeon to more easily sever the conduction path to form a lesion in a desired location.
    Type: Application
    Filed: November 7, 2003
    Publication date: April 15, 2004
    Applicant: Iotek, Inc.
    Inventors: Frederick J. Foley, James S. Sharrow, Lorraine E. Reeve, Thomas G. Adelman, Michael F. Hoey
  • Patent number: 6663622
    Abstract: Devices and a method are provided to assist a surgeon in ablating conduction paths in tissue, such as a heart. A device can be configured to operate as a template that adheres to the tissue surface, and allows the surgeon to more easily sever the conduction path to form a lesion in a desired location. In particular, the template can be used to guide the surgeon's use of a surgical instrument along a desired ablation path. In some case, the template may incorporate hardware that structurally supports the instrument for travel along the ablation path. A surgical instrument such as an ablation probe, e.g., radio frequency, laser, ultrasonic, microwave, thermal, chemical, mechanical, or cryogenic ablation probe, may be used to sever the conduction paths. Measurements made substantially contemporaneously with the conduction path ablation operation may be used to evaluate whether the desired degree of ablation has been achieved.
    Type: Grant
    Filed: August 28, 2000
    Date of Patent: December 16, 2003
    Assignee: Iotek, Inc.
    Inventors: Frederick J. Foley, James S. Sharrow, Lorraine E. Reeve, Thomas G. Adelman, Michael F. Hoey
  • Patent number: 6641604
    Abstract: Devices and methods of manipulating and stabilizing organ tissue, such as heart tissue. The devices, which are of varying sizes, shapes and conformations, generally include a seal member having a chamber with a wall and a skirt-like member that extends outward from the chamber wall for contact with a surface of an organ. The skirt-like member is substantially compliant and tacky, thereby promoting adhesion with the organ surface. Adherence of the device to the tissue may be enhance by the mechanical or hydraulic application of vacuum pressure. The methods describe steps for manipulating, including moving, lifting, immobilizing, turning and reorienting, organ tissues. Additional methods describe steps for manipulating the heart.
    Type: Grant
    Filed: September 18, 2000
    Date of Patent: November 4, 2003
    Assignee: Iotek, Inc.
    Inventors: Thomas G. Adelman, Frederick J. Foley, James S. Sharrow, Lorraine E. Reeve, Michael F. Hoey
  • Publication number: 20030143274
    Abstract: Balanced pH, hyperosmotic, hypoosmotic, or isoosmotic gels are ideal vehicles for drug delivery. They are especially suited for topical body cavity or injection application of drugs or diagnostic agents; for drug or diagnostic agent delivery to the eye of a mammal; as protective corneal shields; or as ablatable corneal masks useful in laser reprofiling of the cornea. The compositions without the addition of a drug or diagnostic agent are useful as medical devices, for instance, in separating surgically or otherwise injured tissue as a means of preventing adhesions.
    Type: Application
    Filed: September 4, 2002
    Publication date: July 31, 2003
    Inventors: Tacey X. Viegas, Lorraine E. Reeve, Raymond L. Henry
  • Publication number: 20030129240
    Abstract: Non-gelling polyoxyalkylene compositions, and methods of their use for inhibiting surgical adhesion formation/reformation in mammals are disclosed. The useful non-gelling compositions preferably comprise polyoxyalkylene block copolymer at desired concentrations with or without a therapeutic agent. When used with an incorporated drug, the non-gelling compositions serve as a carrier providing sustained or prolonged release of the therapeutic agent.
    Type: Application
    Filed: November 12, 2002
    Publication date: July 10, 2003
    Inventors: Lorraine E. Reeve, Stephen G. Flore, Frederick J. Foley, Raymond L. Henry
  • Publication number: 20030108610
    Abstract: The present invention provides a composition comprising one or more constitutive polymers and modifier polymers and/or hydrophilic co-surfactants useful for reducing adhesions or delivering bioactive agents. Methods for preventing and/or reducing post-surgical adhesions or delivering bioactive agents are also provided.
    Type: Application
    Filed: January 2, 2003
    Publication date: June 12, 2003
    Inventors: Stephen G. Flore, Luis A. Dellamary, Lorraine E. Reeve, Jeffry G. Weers
  • Patent number: 6558314
    Abstract: Devices and methods of manipulating and stabilizing organ tissue, such as heart tissue. The devices, which are of varying sizes, shapes and conformations, generally include a seal member having a chamber with a wall and a skirt-like member that extends outward from the chamber wall for contact with a surface of an organ. The skirt-like member is substantially compliant and tacky, thereby promoting adhesion with the organ surface. Adherence of the device to the tissue may be enhance by the mechanical or hydraulic application of vacuum pressure. The methods describe steps for manipulating, including moving, lifting, immobilizing, turning and reorienting, organ tissues. Additional methods describe steps for manipulating the heart.
    Type: Grant
    Filed: October 19, 2000
    Date of Patent: May 6, 2003
    Assignee: Iotek, Inc.
    Inventors: Thomas G. Adelman, Frederick J. Foley, James S. Sharrow, Lorraine E. Reeve, Michael F. Hoey
  • Publication number: 20030077245
    Abstract: Non-gelling polyoxyalkylene compositions, and methods of their use for inhibiting surgical adhesion formation/reformation in mammals are disclosed. The useful non-gelling compositions preferably comprise polyoxyalkylene block copolymer at desired concentrations with or without a therapeutic agent. When used with an incorporated drug, the non-gelling compositions serve as a carrier providing sustained or prolonged release of the therapeutic agent.
    Type: Application
    Filed: July 10, 2002
    Publication date: April 24, 2003
    Inventors: Raymond L. Henry, Lorraine E. Reeve, Stephen G. Flore, Frederick J. Foley
  • Publication number: 20030077328
    Abstract: A method and compositions for reducing post-surgical adhesion formation/reformation in mammals following surgical injury to a body cavity or organs situated therein. The aqueous compositions comprising pentoxifylline and a polyoxyalkylene block copolymer are applied to the injured areas subsequent to surgical injury.
    Type: Application
    Filed: July 10, 2002
    Publication date: April 24, 2003
    Inventors: Lorraine E. Reeve, Stephen G. Flore
  • Publication number: 20020143326
    Abstract: Devices and a method are provided to assist a surgeon in ablating conduction paths in tissue, such as a heart. A device can be configured to operate as a template that adheres to the tissue surface, and allows the surgeon to more easily sever the conduction path to form a lesion in a desired location. In particular, the template can be used to guide the surgeon's use of a surgical instrument along a desired ablation path. In some case, the template may incorporate hardware that structurally supports the instrument for travel along the ablation path. A surgical instrument such as an ablation probe, e.g., radio frequency, laser, ultrasonic, microwave, thermal, chemical, mechanical, or cryogenic ablation probe, may be used to sever the conduction paths. Measurements made substantially contemporaneously with the conduction path ablation operation may be used to evaluate whether the desired degree of ablation has been achieved.
    Type: Application
    Filed: May 28, 2002
    Publication date: October 3, 2002
    Applicant: Lotek, Inc.
    Inventors: Frederick J. Foley, James S. Sharrow, Lorraine E. Reeve, Thomas G. Adelman, Michael F. Hoey
  • Publication number: 20020137973
    Abstract: A process for the purification or fractionation of aqueous soluble polymers using an aqueous two-phase system is described. The concentrations of the polymer to be fractionated and of an aqueous soluble salt, and the temperature of the aqueous fractionation medium are adjusted so that two phases form, the lower molecular weight polymer molecules partition into the high salt concentration phase, and the higher molecular weight polymer molecules partition into the low salt concentration phase. The resulting high molecular weight polymers are characterized by a higher average molecular weight and a narrower molecular weight distribution and decreased unsaturation than the unfractionated polymers. After being subjected to the fractionation process, polyol polymers that form hydrogels in aqueous solution exhibited higher viscosities and a liquid to gel transition over a narrower temperature range than the unfractionated polyol polymers.
    Type: Application
    Filed: August 13, 2001
    Publication date: September 26, 2002
    Inventors: Lorraine E. Reeve, Michael G. Hinsberg
  • Patent number: 6436425
    Abstract: Non-gelling polyoxyalkylene compositions, and methods of their use for inhibiting surgical adhesion formation/reformation in mammals are disclosed. The useful non-gelling compositions preferably comprise polyoxyalkylene block copolymer at desired concentrations with or without a therapeutic agent. When used with an incorporated drug, the non-gelling compositions serve as a carrier providing sustained or prolonged release of the therapeutic agent.
    Type: Grant
    Filed: February 8, 2000
    Date of Patent: August 20, 2002
    Assignee: MDV Technologies, Inc.
    Inventors: Raymond L. Henry, Lorraine E. Reeve, Stephen G. Flore, Frederick J. Foley
  • Publication number: 20020110577
    Abstract: Non-gelling polyoxyalkylene compositions, and methods of their use for inhibiting surgical adhesion formation/reformation in mammals are disclosed. The useful non-gelling compositions preferably comprise polyoxyalkylene block copolymer at desired concentrations with or without a therapeutic agent. When used with an incorporated drug, the non-gelling compositions serve as a carrier providing sustained or prolonged release of the therapeutic agent.
    Type: Application
    Filed: February 8, 2000
    Publication date: August 15, 2002
    Inventors: Raymond L. Henry, Lorraine E. Reeve, Stephen G. Flore, Frederick J. Foley
  • Patent number: 6399624
    Abstract: A method and compositions for reducing post-surgical adhesion formation/reformation in mammals following surgical injury to a body cavity or organs situated therein. The aqueous compositions comprising pentoxifylline and a polyoxyalkylene block copolymer are applied to the injured areas subsequent to surgical injury.
    Type: Grant
    Filed: March 1, 2000
    Date of Patent: June 4, 2002
    Assignee: MDV Technologies, Inc.
    Inventors: Lorraine E. Reeve, Stephen G. Flore
  • Publication number: 20020064514
    Abstract: Balanced pH, thermo-irreversible gels are ideal vehicles for drug delivery to a body cavity of a mammal. The gels contain a mixture of a polyoxyalkylene block copolymer or polyether together with an ionic polysaccharide which is thermo-irreversibly gelled in the presence of a counter-ion.
    Type: Application
    Filed: December 10, 2001
    Publication date: May 30, 2002
    Inventors: Tacey X. Viegas, Lorraine E. Reeve, Raymond L. Henry
  • Publication number: 20020048602
    Abstract: The present invention provides a composition comprising one or more constitutive polymers and modifier polymers and/or hydrophilic co-surfactants useful for reducing adhesions or delivering bioactive agents. Methods for preventing and/or reducing post-surgical adhesions or delivering bioactive agents are also provided.
    Type: Application
    Filed: August 15, 2001
    Publication date: April 25, 2002
    Applicant: Alliance Pharmaceutical Corp.
    Inventors: Stephen G. Flore, Luis A. Dellamary, Lorraine E. Reeve, Jeffry G. Weers