Abstract: The present invention provides methods and assays for screening cells, such as stem cells, for chromosomal aberrations. In particular, the present invention provides a rapid, sensitive assay platform for detecting high and low levels of chromosomal aberrations present in a cell population. This includes, but is not limited to, detection of extra chromosomes (trisomies) as well as insertions of small segments that are undetectable using standard cytogenetic studies, wherein the abnormal cells comprise a low percentage of the total cell population.

Abstract: A composition for reducing the depth or intensity of fine wrinkles in skin affected by intrinsic or photo-induced aging is described. The topical formulation comprises in combination ascorbic acid, tyrosine and a non-toxic zinc salt and is preferably formulated in a hydrophilic ointment or cream base.

Abstract: A method and composition for accelerating the healing of wounds in animals and humans is disclosed. The method comprises administration of ascorbic acid, a source of biologically available calcium, a precursor or stimulant of epinephrine or nor-epinephrine selected from tyrosine and phenylalanine, and an anti-inflammatory substance selected from anti-inflammatory sugars, amino sugars and biocompatible acid addition salts thereof, and anti-inflammatory amino acids. Treatment in accordance with the present method reduces or prevents tissue degenerative effects of the inflammation associated with the natural wound healing process and promotes connective tissue (scar tissue) growth in the wound.

Abstract: A method and composition for treatment of tissue degenerative inflammatory disease in animals and humans afflicted with such disease or disposed to development thereof is disclosed. The method comprises oral administration of ascorbic acid, a source of biologically available calcium, a precursor or stimulant of epinephrine or nor-epinephrine selected from tyrosine and phenylalanine, and an anti-inflammatory substance selected from anti-inflammatory sugars, amino sugars and biocompatible acid addition salts thereof, and anti-inflammatory amino acids. Treatment in accordance with the present method reduces or prevents tissue degenerative effects of the inflammatory disease and promotes connective tissue regrowth.

Abstract: A composition for preventing and treating periodontal disease, comprising bone meal, ascorbic acid, tyrosine, and either glucosamine or cysteine.

Abstract: Peptides, polypeptides, proteins, proteinaceous hormones, and enzymes are modified by covalently bonding chondroitin thereto, whereby their stability toward in vivo degradation is increased.