Patents by Inventor Lorraine Sharp

Lorraine Sharp has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CRYSTALLINE FORMS OF (6S,7S)-6-FLUORO-7-(2-FLUORO-5-METHYLPHENYL)-3-(TETRAHYDRO-2H-PYRAN-4-YL)-5,6,7,8-TETRAHYDROPYRIDO[2,3-d]PYRIMIDINE-2,4(1H,3H)-DIONE
    Publication number: 20250034129
    Abstract: The present invention provides crystalline forms of (6S,7S)-6-fluoro-7-(2-fluoro-5-methylphenyl)-3-(tetrahydro-2H-pyran-4-yl)-5,6,7,8-tetrahydropyrido[2,3-d]pyrimidine-2,4(1H,3H)-dione (“Compound I”). Also provided are related pharmaceutical compositions, methods of preparation, and methods of treating hypertrophic cardiomyopathy (HCM), heart failure with preserved ejection fraction (HFpEF), diastolic dysfunction, left ventricular hypertrophy, and other cardiac diseases.
    Type: Application
    Filed: July 28, 2023
    Publication date: January 30, 2025
    Inventors: Ying YU, David Aimin ZHANG, Juan WANG, Neal HUANG, Jonathan LOUGHREY, Lorraine SHARP, Catherine DALENS, Franck TAILLEZ, Jerome MENEGOTTO, Harikirshna TUMMA, Lin WAN, Wei WANG, Rongfei YANG, Zheng Jane LI, Ruiping WANG, Yue LU
  • THERMODYNAMICALLY STABLE FORM OF SCO-101
    Publication number: 20240360087
    Abstract: The present invention relates to an improved crystal form of SCO-101, its preparation and use. Further, the invention relates to intermediary crystal forms of SCO-101 that can be converted to the improved crystal form of SCO-101.
    Type: Application
    Filed: July 11, 2022
    Publication date: October 31, 2024
    Inventors: Kaare G. RASMUSSEN, René EGEBRO, Klaus Snej JENSEN, Kiara LOBATO, Lorraine SHARP
  • CRYSTALLINE FORMS OF HYDROXYNORKETAMINE
    Publication number: 20220306569
    Abstract: The present invention provides novel, stable, processable and pharmaceutically acceptable salt forms of 2R,6R-hydrox-ynorketamineor 2S,6S-hydroxynorketamine with high aqueous solubility.
    Type: Application
    Filed: May 27, 2022
    Publication date: September 29, 2022
    Applicant: Small Pharma Ltd
    Inventors: David PEARSON, Lorraine SHARP, Alan ARMSTRONG, Richard MYERSON, Jonathan HULL, Paul BLANEY, Peter RANDS, Marie LAYZELL, Zelah JOEL
  • Crystalline forms of hydroxynorketamine
    Patent number: 11377416
    Abstract: The present invention provides novel, stable, processable and pharmaceutically acceptable salt forms of 2R,6R-hydroxynorketamine or 2S,6S-hydroxynorketamine with high aqueous solubility.
    Type: Grant
    Filed: July 31, 2018
    Date of Patent: July 5, 2022
    Assignee: SMALL PHARMA LTD.
    Inventors: David Pearson, Lorraine Sharp, Alan Armstrong, Richard Myerson, Jonathan Hull, Paul Blaney, Peter Rands, Marie Layzell, Zelah Joel
  • SOLID ORAL DOSAGE FORMS OF KETAMINE DERIVATIVES
    Publication number: 20210315840
    Abstract: This invention relates to high concentration solid oral dosage forms of a ketamine metabolite selected from 2R,6R-hydroxynorketamine, 2S,6S-hydroxynorketamine, R-5,6-dehydronorketamine and S-5,6-dehydronorketamine.
    Type: Application
    Filed: September 25, 2018
    Publication date: October 14, 2021
    Applicant: SMALL PHARMA LTD
    Inventors: Trevor ROBBINS, Benjamin PHILLIPS, David PEARSON, Lorraine SHARP, Richard MYERSON, Peter RANDS, Marie LAYZELL, Zelab JOEL, Tiffanie BENWAY, Ellen JAMES
  • CRYSTALLINE FORMS OF HYDROXYNORKETAMINE
    Publication number: 20200157040
    Abstract: The present invention provides novel, stable, processable and pharmaceutically acceptable salt forms of 2R,6R-hydroxynorketamine or 2S,6S-hydroxynorketamine with high aqueous solubility.
    Type: Application
    Filed: July 31, 2018
    Publication date: May 21, 2020
    Applicant: SMALL PHARMA LTD
    Inventors: David Pearson, Lorraine Sharp, Alan Armstrong, Richard Myerson, Jonathan Hull, Paul Blaney, Peter Rands, Marie Layzell, Zelah Joel