Patents by Inventor Lorrie Kirshenbaum

Lorrie Kirshenbaum has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Small molecule BAX inhibitors and uses thereof
    Patent number: 11938128
    Abstract: Compounds, compositions and method of using these compounds are disclosed for treating a disease or disorder in which it is desirable to inhibit BAX, such as a cardiovascular disease or disorder.
    Type: Grant
    Filed: March 9, 2018
    Date of Patent: March 26, 2024
    Assignees: Albert Einstein College of Medicine, The University of Manitoba
    Inventors: Evripidis Gavathiotis, Richard N. Kitsis, Thomas P. Garner, Dulguun Amgalan, Lorrie Kirshenbaum, Felix Kopp
  • SMALL MOLECULE BAX INHIBITORS AND USES THEREOF
    Publication number: 20200009132
    Abstract: Compounds, compositions and method of using these compounds are disclosed for treating a disease or disorder in which it is desirable to inhibit BAX, such as a cardiovascular disease or disorder.
    Type: Application
    Filed: March 9, 2018
    Publication date: January 9, 2020
    Inventors: Evripidis Gavathiotis, Richard N. Kitsis, Thomas Peter Garner, Dulguun Amgalan, Lorrie Kirshenbaum, Felix Kopp
  • BNIP3 ISOFORMS AND METHODS OF USE
    Publication number: 20130196922
    Abstract: The present invention provides isolated splice variants of Bnip3 and isolated polynucleotides encoding the splice variants. Also provided are isolated polypeptides present at the carboxy-terminus of Bnip3 splice variants, and antibody that specifically binds Bnip3 splice variants and/or the carboxy-terminus of Bnip3 splice variants. The present invention further provides methods of altering cellular apoptosis, cellular necrosis, cellular autophagy, or the combination thereof. For instance, the methods may include changing the amount of a Bnip3 splice variant or a carboxy-terminal region of a Bnip3 splice variant in a cell. Also provided herein are methods for determining whether death of cells in a tissue can be altered, methods for evaluating treatment options for a subject, and methods for identifying a compound that alters the amount or activity of a Bnip3 splice variant in a cell.
    Type: Application
    Filed: July 18, 2011
    Publication date: August 1, 2013
    Applicant: UNIVERSITY OF MANITOBA
    Inventor: Lorrie A. Kirshenbaum
  • NIP3 family of proteins
    Patent number: 7452869
    Abstract: Methods and compositions for modulating necrosis and for treating neurological and cardiovascular diseases are described. The inventors have shown that BNIP3 is involved in cell necrosis and cell death involved in cardiovascular and neurological diseases.
    Type: Grant
    Filed: November 8, 2002
    Date of Patent: November 18, 2008
    Assignee: University of Manitoba
    Inventors: Faye Hellner, legal representative, Jonathan D. Geiger, Lorrie A. Kirshenbaum, Arnold H. Greenberg
  • NIP3 family of proteins
    Publication number: 20030203867
    Abstract: Methods and compositions for modulating necrosis and for treating neurological and cardiovascular diseases are described. The inventors have shown that BNIP3 is involved in cell necrosis and cell death involved in cardiovascular and neurological diseases.
    Type: Application
    Filed: November 8, 2002
    Publication date: October 30, 2003
    Inventors: Arnold H. Greenberg, Jonathan D. Geiger, Lorrie A. Kirshenbaum, Faye Hellner