Patents by Inventor Lothar Hennighausen

Lothar Hennighausen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Targeting gene expression to living tissue using jet injection
    Publication number: 20040193111
    Abstract: The present invention provides a method of targeting transient gene expression and stable gene expression from the exogenous administration of a DNA sequence, which sequence is less than a complete genome, wherein said DNA sequence encodes RNA and protein, or RNA only, to differentiate tissue of living organisms wherein said DNA sequence through a jet injector technique, and said DNA sequence of less than a complete genome is expressed in a living organism. The present invention further provides a flexible multi-nozzle injector device with a wide surface area to allow molding of the injector nozzle to the surface contours of the tissue. Another aspect of the present invention provides an injection device having a long nozzle for injection of DNA deep into the host tissue. Also, in a further aspect the present invention provides an injector device. modified to be used with and/or inject through an endoscopic device.
    Type: Application
    Filed: January 20, 2004
    Publication date: September 30, 2004
    Applicant: Government of the USA, represented by the Secretary, Department of Health and Human Services
    Inventors: Priscilla Anne Furth, Lothar Hennighausen
  • Targeting gene expression to living tissue using jet injection
    Patent number: 6730663
    Abstract: The present invention provides a method of targeting transient gene expression and stable gene expression from the exogenous administration of a DNA sequence, which sequence is less than a complete genome, wherein said DNA sequence encodes RNA and protein, or RNA only, to differentiate tissue of living organisms wherein said DNA sequence through a jet injector technique, and said DNA sequence of less than a complete genome is expressed in a living organism. The present invention further provides a flexible multi-nozzle injector device with a wide surface area to allow molding of the injector nozzle to the surface contours of the tissue. Another aspect of the present invention provides an injection device having a long nozzle for injection of DNA deep into the host tissue. Also, in a further aspect the present invention provides an injector device modified to be used with and/or inject through an endoscopic device.
    Type: Grant
    Filed: January 2, 2002
    Date of Patent: May 4, 2004
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Priscilla Anne Furth, Lothar Hennighausen
  • Transgenic animals secreting desired proteins into milk
    Patent number: 6727405
    Abstract: A DNA sequence containing a gene encoding a protein, the gene being under the transcriptional control in the DNA sequence of a mammalian milk protein promoter which does not naturally control the transcription of the gene, such DNA sequence including DNA enabling secretion of the protein.
    Type: Grant
    Filed: May 19, 1994
    Date of Patent: April 27, 2004
    Assignee: Genzyme Corporation
    Inventors: Katherine Gordon, Suzanne Groet, Lothar Hennighausen, Heiner Westphal
  • Targeting gene expression to living tissue using jet injection
    Publication number: 20020123148
    Abstract: The present invention provides a method of targeting transient gene expression and stable gene expression from the exogenous administration of a DNA sequence, which sequence is less than a complete genome, wherein said DNA sequence encodes RNA and protein, or RNA only, to differentiate tissue of living organisms wherein said DNA sequence through a jet injector technique, and said DNA sequence of less than a complete genome is expressed in a living organism. The present invention further provides a flexible multi-nozzle injector device with a wide surface area to allow molding of the injector nozzle to the surface contours of the tissue. Another aspect of the present invention provides an injection device having a long nozzle for injection of DNA deep into the host tissue. Also, in a further aspect the present invention provides an injector device modified to be used with and/or inject through an endoscopic device.
    Type: Application
    Filed: January 2, 2002
    Publication date: September 5, 2002
    Applicant: Department of Health and Human Services
    Inventors: Priscilla Anne Furth, Lothar Hennighausen
  • Targeting gene expression to living tissue using jet injection
    Patent number: 6361991
    Abstract: The present invention provides a method of targeting transient gene expression and stable gene expression from the exogenous administration of a DNA sequence, which sequence is less than a complete genome, wherein said DNA sequence encodes RNA and protein, or RNA only, to differentiate tissue of living organisms wherein said DNA sequence through a jet injector technique, and said DNA sequence of less than a complete genome is expressed in a living organism. The present invention further provides a flexible multi-nozzle injector device with a wide surface area to allow molding of the injector nozzle to the surface contours of the tissue. Another aspect of the present invention provides an injection device having a long nozzle for injection of DNA deep into the host tissue. Also, in a further aspect the present invention provides an injector device modified to be used with and/or inject through an endoscopic device.
    Type: Grant
    Filed: November 2, 1999
    Date of Patent: March 26, 2002
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Priscilla Anne Furth, Lothar Hennighausen
  • Expression of a heterologous protein C in mammary tissue of transgenic animals using a long whey acidic protein promoter
    Patent number: 6262336
    Abstract: An isolated DNA sequence which regulates the expression of a heterologous gene composed of a mouse whey acidic protein promoter having a length of greater than about 2.4 kb extending upstream from the unique KpnI site in the mouse whey acidic protein gene is disclosed. Specifically a mouse whey acidic protein promoter of about 4.1-4.2 kb in length extending upstream from the unique KpnI site is preferred. This mouse whey acid protein promoter is operably linked to a DNA sequence encoding a heterologous polypeptide and used to prepare transgenic non-human mammals expressing the heterologous polypeptide in their milk. Particularly efficient expression of both cDNAs and genomic DNAs encoding heterologous polypeptides was obtained in transgenic non-human mammals using this promoter, known as the long whey acidic protein promoter.
    Type: Grant
    Filed: May 28, 1999
    Date of Patent: July 17, 2001
    Assignees: American Red Cross, Virginia Tech Intellectual Properties, Inc., The United States of America as represented by the Department of Health and Human Services
    Inventors: Henryk Lubon, William N. Drohan, Lothar Hennighausen, William H. Velander
  • Targeting gene expression to living tissue using jet injection
    Patent number: 5998382
    Abstract: The present invention provides a method of targeting transient gene expression and stable gene expression from the exogenous administration of a DNA sequence, which sequence is less than a complete genome, wherein said DNA sequence encodes RNA and protein, or RNA only, to differentiate tissue of living organisms wherein said DNA sequence through a jet injector technique, and said DNA sequence of less than a complete genome is expressed in a living organism. The present invention further provides a flexible multi-nozzle injector device with a wide surface area to allow molding of the injector nozzle to the surface contours of the tissue. Another aspect of the present invention provides an injection device having a long nozzle for injection of DNA deep into the host tissue. Also, in a further aspect the present invention provides an injector device modified to be used with and/or inject through an endoscopic device.
    Type: Grant
    Filed: May 2, 1995
    Date of Patent: December 7, 1999
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Priscilla Anne Furth, Lothar Hennighausen