Abstract: A system for manipulation of a tissue sample includes a chassis, a chamber defined in the chassis and configured to receive and retain a complimentary device including a sample processing compartment disposed between sheets of a flexible material and a waste chamber disposed between the sheets of the flexible material. The complimentary device is configured to retain the tissue sample during manipulation of the tissue sample by the system. A fluid mixing sub-system is configured to agitate and mix a fluid including the tissue sample within the sample processing compartment. A temperature control sub-system including at least one of a first heating element and a first cooling element is configured and arranged to be in thermal communication with the sample processing compartment. An electronic controller is in communication with, and programmed to control operation of the fluid mixing sub-system and the temperature control sub-systems.

Abstract: Embodiments of the present disclosure feature a filtration system comprising a filtration module for particle filtration and methods of using the device for the isolation of particles (e.g., viable cells). Advantageously, embodiments of the device provide for the high throughput filtration of large volumes of sample while preserving cell viability and providing high yields.

Abstract: In accordance with an aspect of the present disclosure there is provided an apparatus for the processing of biological sample. The apparatus comprises a first sheet of material, a second sheet of material bonded to the first sheet of material, and a plurality of chambers defined between the first sheet of material and the second sheet of material, the plurality of chambers including a sample dissociation chamber including an inlet and an outlet; a waste collection chamber including an inlet in fluid communication with the outlet of the sample dissociation chamber, and a cell refinement chamber including an inlet in fluid communication with the sample dissociation chamber and an outlet.

Abstract: Embodiments of the present disclosure feature a filtration system comprising a filtration module for particle filtration and methods of using the device for the isolation of particles (e.g., viable cells). Advantageously, embodiments of the device provide for the high throughput filtration of large volumes of sample while preserving cell viability and providing high yields.

Abstract: The present invention features a new and useful magnetic device and methods of its use for isolation, enrichment, and purification of cells, proteins, DNA, and other molecules. In general the device includes magnetic regions or obstacles to which magnetic particles can bind. The chemical groups, i.e., capture moieties, on the surface of the magnetic particles may then be used to bind particles, e.g., cells, or molecules of interest from complex samples, and the bound species may then be selectively released for downstream collection or further analysis.