Patents by Inventor Lou Dietz
Lou Dietz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220021823Abstract: Disclosed herein are embodiments of imaging biological specimens. An imaging system can include a microscope for directly viewing the biological specimen and a multi-spectral imaging apparatus for outputting digitally enhanced images, near-video rate imaging, and/or videos of the specimen. An imaging system can include a digital scanner that digitally processes images to produce a composite image with enhanced color contrast of features of interest.Type: ApplicationFiled: June 11, 2021Publication date: January 20, 2022Inventors: Larry Morrison, Lou Dietz
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Patent number: 11070750Abstract: Disclosed herein are embodiments of imaging biological specimens. An imaging system can include a microscope for directly viewing the biological specimen and a multi-spectral imaging apparatus for outputting digitally enhanced images, near-video rate imaging, and/or videos of the specimen. An imaging system can include a digital scanner that digitally processes images to produce a composite image with enhanced color contrast of features of interest.Type: GrantFiled: July 28, 2020Date of Patent: July 20, 2021Assignee: Ventana Medical Systems, Inc.Inventors: Larry Morrison, Lou Dietz
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Publication number: 20200358969Abstract: Disclosed herein are embodiments of imaging biological specimens. An imaging system can include a microscope for directly viewing the biological specimen and a multi-spectral imaging apparatus for outputting digitally enhanced images, near-video rate imaging, and/or videos of the specimen. An imaging system can include a digital scanner that digitally processes images to produce a composite image with enhanced color contrast of features of interest.Type: ApplicationFiled: July 28, 2020Publication date: November 12, 2020Inventors: Larry Morrison, Lou Dietz
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Patent number: 10778913Abstract: An imaging system that can include a microscope for directly viewing a biological specimen and a multi-spectral imaging apparatus for outputting digitally enhanced images, near-video rate imaging, and/or videos of the specimen. An imaging system that can include a digital scanner that digitally processes images to produce a composite image with enhanced color contrast of features of interest.Type: GrantFiled: September 13, 2013Date of Patent: September 15, 2020Assignee: Ventana Medical Systems, Inc.Inventors: Larry Morrison, Lou Dietz
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Patent number: 10242248Abstract: The subject disclosure presents systems and methods for separating colors in an image by automatically and adaptively adjusting reference vectors based on information specific to the assay being imaged, resulting in an optimized unmixing process that provides stain information that is physically and physiologically plausible. The reference vectors are optimized iteratively, based on minimizing non-negative color contributions, background contributions, high-frequencies in color channels specific to background or unwanted fluorescence, signals from known immunohistochemical markers, and pairs of stains known to carry physiologically independent information. Adjustments to the reference vectors may be allowed within a range that is predetermined based on measuring colors from multiple input images.Type: GrantFiled: May 28, 2014Date of Patent: March 26, 2019Assignee: Ventana Medical Systems, Inc.Inventors: Joerg Bredno, Lou Dietz, Jim F. Martin
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Patent number: 9792693Abstract: Processing of images acquired via fluorescence microscopy by identifying broadband and other undesired signals from the component signals of a scanned image, and processing selected regions of the image that are known to contain signals of interest, thereby extracting or identifying desired signals while subtracting undesired signals. One or more broadband signals are recognized by their unique signature and ubiquitous dispersion through the image. Regions of the scanned image may be tagged as consisting of predominantly broadband signals and are ignored during a spectral unmixing process. The remaining regions of the image, or selected regions of the image known to contain desired signals, may be unmixed, and the plurality of reference spectra subtracted from the components to extract or identify the target signals. The set of target signals may be refined by eliminating known or obvious sources of noise by, for instance, being compared to known or ideal sets of signals from similar materials.Type: GrantFiled: March 13, 2014Date of Patent: October 17, 2017Assignee: VENTANA MEDICAL SYSTEMS, INC.Inventors: Pascal Bamford, Srinivas Chukka, Lou Dietz, Ronald T. Kurnik, Bikash Sabata, Anindya Sarkar, Olcay Sertel
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Publication number: 20160131583Abstract: An imaging system (100) is capable of detecting of tissue situated on a microscope slide (180). The imaging system (100) includes a light source (150), an image capturing device (160) including a camera, and an imaging lens (170). The light source (150) directs light (154) towards one or more of the edges of the slide (180) such that the light (154) undergoes total internal reflection between a surface of the slide (180) and a coverslip (182) carried by the slide (180). The light (154) has a wavelength or waveband designed to stimulate one or more specimens carried on the slide (180). The imaging lens (170) is positioned to direct radiation emitted from the tissue and/or fluorophore onto the camera. The image capturing device (160) can capture an image of the whole slide (180) or a portion thereof.Type: ApplicationFiled: May 28, 2014Publication date: May 12, 2016Applicant: VENTANA MEDICAL SYSTEMS, INC.Inventors: Pascal Bamford, Lou Dietz, Elizabeth Little
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Publication number: 20160098590Abstract: The subject disclosure presents systems and methods for separating colors in an image by automatically and adaptively adjusting reference vectors based on information specific to the assay being imaged, resulting in an optimized unmixing process that provides stain information that is physically and physiologically plausible. The reference vectors are optimized iteratively, based on minimizing non-negative color contributions, background contributions, high-frequencies in color channels specific to background or unwanted fluorescence, signals from known immunohistochemical markers, and pairs of stains known to carry physiologically independent information. Adjustments to the reference vectors may be allowed within a range that is predetermined based on measuring colors from multiple input images.Type: ApplicationFiled: May 28, 2014Publication date: April 7, 2016Inventors: Joerg Bredno, Lou Dietz, Jim F. Martin
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Publication number: 20160035100Abstract: Processing of images acquired via fluorescence microscopy by identifying broadband and other undesired signals from the component signals of a scanned image, and processing selected regions of the image that are known to contain signals of interest, thereby extracting or identifying desired signals while subtracting undesired signals. One or more broadband signals are recognized by their unique signature and ubiquitous dispersion through the image. Regions of the scanned image may be tagged as consisting of predominantly broadband signals and are ignored during a spectral unmixing process. The remaining regions of the image, or selected regions of the image known to contain desired signals, may be unmixed, and the plurality of reference spectra subtracted from the components to extract or identify the target signals. The set of target signals may be refined by eliminating known or obvious sources of noise by, for instance, being compared to known or ideal sets of signals from similar materials.Type: ApplicationFiled: March 13, 2014Publication date: February 4, 2016Inventors: Pascal BAMFORD, Srinivas CHUKKA, Lou DIETZ, Ronald T. KURNIK, Bikash SABATA, Anindya SARKAR, Olcay SERTEL
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Publication number: 20140267672Abstract: Disclosed herein are embodiments of imaging biological specimens. An imaging system can include a microscope for directly viewing the biological specimen and a multi-spectral imaging apparatus for outputting digitally enhanced images, near-video rate imaging, and/or videos of the specimen. An imaging system can include a digital scanner that digitally processes images to produce a composite image with enhanced color contrast of features of interest.Type: ApplicationFiled: September 13, 2013Publication date: September 18, 2014Inventors: Larry Morrison, Lou Dietz
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Patent number: 8797396Abstract: Provided herein are systems methods including a design of a microscope slide scanner for digital pathology applications which provides high quality images and automated batch-mode operation at low cost. The instrument architecture is advantageously based on a convergence of high performance, yet low cost, computing technologies, interfaces and software standards to enable high quality digital microscopy at very low cost. Also provided is a method based in part on a stitching method that allows for dividing an image into a number of overlapping tiles and reconstituting the image with a magnification without substantial loss of accuracy. A scanner is employed in capturing snapshot images. The method allows for overlapping images captured in consecutive snapshots.Type: GrantFiled: December 6, 2011Date of Patent: August 5, 2014Assignee: Ventana Medical Systems, Inc.Inventors: Lou Dietz, Kurt Kuhlmann, Christopher Todd, Glenn Stark, Barry Rodriguez, Gregory Loney
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Patent number: 8675992Abstract: Provided herein are systems methods including a design of a microscope slide scanner for digital pathology applications which provides high quality images and automated batch-mode operation at low cost. The instrument architecture is advantageously based on a convergence of high performance, yet low cost, computing technologies, interfaces and software standards to enable high quality digital microscopy at very low cost. Also provided is a method based in part on a stitching method that allows for dividing an image into a number of overlapping tiles and reconstituting the image with a magnification without substantial loss of accuracy. A scanner is employed in capturing snapshot images. The method allows for overlapping images captured in consecutive snapshots.Type: GrantFiled: December 6, 2011Date of Patent: March 18, 2014Assignee: Ventana Medical Systems, Inc.Inventors: Lou Dietz, Lokesh Tatke, Suraj Somwanshi, Suhas Patil, Sujit Chivate
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Publication number: 20120092481Abstract: Provided herein are systems methods including a design of a microscope slide scanner for digital pathology applications which provides high quality images and automated batch-mode operation at low cost. The instrument architecture is advantageously based on a convergence of high performance, yet low cost, computing technologies, interfaces and software standards to enable high quality digital microscopy at very low cost. Also provided is a method based in part on a stitching method that allows for dividing an image into a number of overlapping tiles and reconstituting the image with a magnification without substantial loss of accuracy. A scanner is employed in capturing snapshot images. The method allows for overlapping images captured in consecutive snapshots.Type: ApplicationFiled: December 6, 2011Publication date: April 19, 2012Applicant: Ventana Medical Systems, Inc.Inventors: Lou Dietz, Kurt Kuhlmann, Lokesh Tatke, Suraj Somwanshi, Christopher Todd, Glenn Stark, Barry Rodriguez, Gregory Loney, Bikash Sabata, Ronald L. Allen, Suhas Patil, Sujit Chivate, Prashanth Ravindran, Sanford Barsky
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Publication number: 20120076436Abstract: Provided herein are systems methods including a design of a microscope slide scanner for digital pathology applications which provides high quality images and automated batch-mode operation at low cost. The instrument architecture is advantageously based on a convergence of high performance, yet low cost, computing technologies, interfaces and software standards to enable high quality digital microscopy at very low cost. Also provided is a method based in part on a stitching method that allows for dividing an image into a number of overlapping tiles and reconstituting the image with a magnification without substantial loss of accuracy. A scanner is employed in capturing snapshot images. The method allows for overlapping images captured in consecutive snapshots.Type: ApplicationFiled: December 7, 2011Publication date: March 29, 2012Applicant: Ventana Medical Systems, Inc.Inventors: Lou Dietz, Kurt Kuhlmann, Lokesh Tatke, Suraj Somwanshi, Christopher Todd, Glenn Stark, Barry Rodriguez, Gregory Loney, Bikash Sabata, Ronald L. Allen, Suhas Patil, Sujit Chivate, Prashanth Ravindran, Sanford Barsky
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Publication number: 20120076411Abstract: Provided herein are systems methods including a design of a microscope slide scanner for digital pathology applications which provides high quality images and automated batch-mode operation at low cost. The instrument architecture is advantageously based on a convergence of high performance, yet low cost, computing technologies, interfaces and software standards to enable high quality digital microscopy at very low cost. Also provided is a method based in part on a stitching method that allows for dividing an image into a number of overlapping tiles and reconstituting the image with a magnification without substantial loss of accuracy. A scanner is employed in capturing snapshot images. The method allows for overlapping images captured in consecutive snapshots.Type: ApplicationFiled: December 6, 2011Publication date: March 29, 2012Applicant: Ventana Medical Systems, Inc.Inventors: Lou Dietz, Kurt Kuhlmann, Lokesh Tatke, Suraj Somwanshi, Christopher Todd, Glenn Stark, Barry Rodriguez, Gregory Loney, Bikash Sabata, Ronald L. Allen, Suhas Patil, Sujit Chivate, Prashanth Ravindran, Sanford Barsky
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Publication number: 20120076391Abstract: Provided herein are systems methods including a design of a microscope slide scanner for digital pathology applications which provides high quality images and automated batch-mode operation at low cost. The instrument architecture is advantageously based on a convergence of high performance, yet low cost, computing technologies, interfaces and software standards to enable high quality digital microscopy at very low cost. Also provided is a method based in part on a stitching method that allows for dividing an image into a number of overlapping tiles and reconstituting the image with a magnification without substantial loss of accuracy. A scanner is employed in capturing snapshot images. The method allows for overlapping images captured in consecutive snapshots.Type: ApplicationFiled: December 6, 2011Publication date: March 29, 2012Applicant: Ventana Medical Systems, Inc.Inventors: Lou Dietz, Kurt Kuhlmann, Lokesh Tatke, Suraj Somwanshi, Christopher Todd, Glenn Stark, Barry Rodriguez, Gregory Loney, Bikash Sabata, Ronald L. Allen, Suhas Patil, Sujit Chivate, Prashanth Ravindran, Sanford Barsky
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Publication number: 20090162941Abstract: The present invention relates to methods and devices for air ingestion prevention. The invention provides a stopper or plug with one or more conduits and a recess that prevents air ingestion during outlet of a liquid from a liquid container covered with the stopper.Type: ApplicationFiled: December 21, 2007Publication date: June 25, 2009Inventors: James Winkler, Robyn Bennis, Lou Dietz, Keith Moravick, Haile Negussie
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Publication number: 20080240613Abstract: Provided herein are systems methods including a design of a microscope slide scanner for digital pathology applications which provides high quality images and automated batch-mode operation at low cost. The instrument architecture is advantageously based on a convergence of high performance, yet low cost, computing technologies, interfaces and software standards to enable high quality digital microscopy at very low cost. Also provided is a method based in part on a stitching method that allows for dividing an image into a number of overlapping tiles and reconstituting the image with a magnification without substantial loss of accuracy. A scanner is employed in capturing snapshot images. The method allows for overlapping images captured in consecutive snapshots.Type: ApplicationFiled: March 24, 2008Publication date: October 2, 2008Applicant: BIOIMAGENE, INC.Inventors: Lou Dietz, Kurt Kuhlmann, Lokesh Tatke, Suraj Somwanshi, Christopher Todd, Glenn Stark, Barry Rodriguez, Gregory Loney, Bikash Sabata, Ronald L. Allen, Suhas Patil, Sujit Chivate, Prashanth Ravindran, Sanford Barsky