Patents by Inventor Louai LABANIEH

Louai LABANIEH has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240082399
    Abstract: Provided are recombinant polypeptides that comprise a protein of interest, a protein localization tag, and a protease cleavage site disposed between the protein of interest and the protein localization tag. In certain embodiments, the recombinant polypeptides further comprise a protease, where the protease cleavage site is a cleavage site for the protease. Also provided are nucleic acids that encode the recombinant polypeptides, cells that comprise such nucleic acids, and compositions (e.g., pharmaceutical compositions) that comprise such cells. Methods of regulating cellular localization of a protein of interest, and methods of administering a regulatable cell-based therapy to an individual in need thereof, are also provided.
    Type: Application
    Filed: October 9, 2020
    Publication date: March 14, 2024
    Inventors: Crystal Mackall, Robbie Majzner, Louai Labanieh, Michael Lin
  • Publication number: 20230183312
    Abstract: Disclosed are chimeric antigen receptors comprising a CD2 co-stimulatory domain that retain function against CD58? and CD58low tumor cells, and CD2 co-stimulatory receptors that promote CAR function against CD58? and CD58low tumor cells.
    Type: Application
    Filed: February 12, 2021
    Publication date: June 15, 2023
    Inventors: Robbie G. MAJZNER, Crystal L. MACKALL, Aidan TOUSLEY, Michelle MONJE-DEISSEROTH, Louai LABANIEH, Christopher MOUNT
  • Publication number: 20220218751
    Abstract: The present disclosure generally relates to, inter alia, novel chimeric polypeptides and chimeric antigen receptors (CARs) that include a hinge domain from CD28 and optionally a costimulatory domain not from CD28. The disclosure also provides compositions and methods useful for producing such molecules, as well as methods for the detection and treatment of diseases, such as cancer.
    Type: Application
    Filed: May 6, 2020
    Publication date: July 14, 2022
    Inventors: Robbie G. Majzner, Crystal L. Mackall, Louai Labanieh, Skyler P. Rietberg
  • Publication number: 20220041686
    Abstract: Provided herein are cell surface receptors that include an extracellular binding domain, a transmembrane domain, an intracellular signaling domain, and a protease cleavage site disposed between the extracellular binding domain and the intracellular signaling domain. In certain aspects, the cell surface receptors are engineered cell surface receptors, such as chimeric antigen receptors (CARs). Also provided are cells that include such receptors (e.g., where the cells express the receptors on their surface) and pharmaceutical compositions including such cells. Nucleic acids that encode the cell surface receptors, cells including such nucleic acids, and pharmaceutical compositions including such cells, are also provided. Also provided are methods for regulating signaling of a cell surface receptor, and methods of using the cells of the present disclosure, including methods of using such cells to administer a regulatable cell-based therapy to an individual.
    Type: Application
    Filed: December 5, 2019
    Publication date: February 10, 2022
    Inventors: Crystal Mackall, Louai Labanieh, Robbie Majzner, Michael Z. Lin
  • Publication number: 20210171602
    Abstract: Provided are polypeptides that include, from N-terminus to C-terminus, a chimeric antigen receptor (CAR), a protease, and a degron, where the polypeptide further includes a cleavage site for the protease disposed between the CAR and the degron. Also provided are cells that include such polypeptides (e.g., where the cells express the CAR on their surface) and pharmaceutical compositions including such cells. Nucleic acids that encode the polypeptides, cells including such nucleic acids, and pharmaceutical compositions including such cells, are also provided. Also provided are methods for controlling the expression of a CAR on the surface of a cell, and methods of using the cells of the present disclosure, including methods of using such cells to administer a regulatable CAR cell-based therapy (e.g., a regulatable CAR T cell therapy) to an individual.
    Type: Application
    Filed: July 3, 2019
    Publication date: June 10, 2021
    Inventors: Crystal Mackall, Michael Lin, Robbie Majzner, Hokyung Chung, Louai Labanieh
  • Publication number: 20190046985
    Abstract: In alternative embodiments, provided are high-throughput, multiplexed systems or methods for detecting a chemical, biological, a physiological or a pathological analyte, or a single molecule or a single cell in droplets using the floating droplet array system, whereby droplets are trapped in an array of trapping structures. In alternative embodiments, high-throughput, multiplexed systems as provided herein are integrated with portable imaging systems such as CCD, CMOS, digital camera, or cell phone-based imaging.
    Type: Application
    Filed: September 15, 2016
    Publication date: February 14, 2019
    Inventors: Dong-ku KANG, Weian ZHAO, Louai LABANIEH
  • Publication number: 20160231324
    Abstract: In alternative embodiments, the invention provides high throughput, multiplexed systems or methods for detecting a biological, a physiological or a pathological maker, or a single molecule or a single cell using a droplet microfluidics system integrated with use of a sensor or a sensing system, an aptamer, or a DNAzyme. In alternative embodiments, the sensor or sensing system comprises a nucleic acid based, an antibody based, an enzyme based or a chemical based sensor or sensing system. In alternative embodiments, the invention provides methods for detecting a biological, a physiological or a pathological marker, or a single molecule or a single cell using a droplet system integrated with rapid and sensitive fluorescence detection systems including, for example, a 3D Particle Detector. In alternative embodiments, the invention provides systems comprising Integrated Comprehensive Droplet Digitial Detection (IC 3D).
    Type: Application
    Filed: September 24, 2014
    Publication date: August 11, 2016
    Inventors: Weian ZHAO, Dong-ku KANG, Kaixiang ZHANG, Md Monsur ALI, Mark A. ECKERT, Feng LI, Enrico GRATTON, MIchelle A. DIGMAN, Louai LABANIEH, Mengrou LU