Patents by Inventor Louis A. Carpino

Louis A. Carpino has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 5,6-dimethoxy-1,1-dioxobenzo[b]thiophene-2-methyloxycarbonyl (DM-Bsmoc) and related amino-protecting groups
    Patent number: 9975870
    Abstract: Amino acid protecting groups are provided for use in peptide synthesis. Particular compounds disclosed include 5,6-dimethoxy-1,1-dioxobenzo[b]thiophi methyloxycarbonyl (DM-Bsmoc) and related amino-protecting groups.
    Type: Grant
    Filed: July 16, 2014
    Date of Patent: May 22, 2018
    Assignee: MASSACHUSETTS, UNIVERSITY OF
    Inventors: Louis A. Carpino, Adel A. Abdel-Maksoud, Hesham A. Ahmed, Calin Dan Sferdean
  • THE 5,6-DIMETHOXY-1,1-DIOXOBENZO[B]THIOPHENE-2-METHYLOXYCARBONYL (DM-BSMOC) AND RELATED AMINO-PROTECTING GROUPS
    Publication number: 20160152591
    Abstract: Amino acid protecting groups are provided for use in peptide synthesis. Particular compounds disclosed include 5,6-dimethoxy-1,1-dioxobenzo[b]thiophi methyloxycarbonyl (DM-Bsmoc) and related amino-protecting groups.
    Type: Application
    Filed: July 16, 2014
    Publication date: June 2, 2016
    Inventors: Louis A. Carpino, Adel A. Abdel-Maksoud, Hesham A. Ahmed, Calin Dan Sferdean
  • Coupling agents for peptide synthesis
    Patent number: 8471006
    Abstract: The present invention is directed to compounds of the formula: or salts thereof or N-oxides and their use in peptide synthesis.
    Type: Grant
    Filed: July 9, 2012
    Date of Patent: June 25, 2013
    Assignee: University of Massachusetts
    Inventors: Louis A. Carpino, Jusong Xia, Chongwu Zhang, Calin Dan Sferdean
  • NEW COUPLING AGENTS FOR PEPTIDE SYNTHESIS
    Publication number: 20120277428
    Abstract: The present invention is directed to compounds of the formula: or salts thereof or N-oxides and their use in peptide synthesis.
    Type: Application
    Filed: July 9, 2012
    Publication date: November 1, 2012
    Inventors: Louis A. Carpino, Jusong Xia, Chongwu Zhang, Calin Dan Sferdean
  • Coupling agents for peptide synthesis
    Patent number: 8217169
    Abstract: The present invention is directed to compounds of the formula: or salts thereof or N-oxides and their use in peptide synthesis.
    Type: Grant
    Filed: October 11, 2010
    Date of Patent: July 10, 2012
    Assignee: University of Massachusetts
    Inventors: Louis A. Carpino, Jusong Xia, Chongwu Zhang, Calin Dan Sferdean
  • New Coupling Agents for Peptide Synthesis
    Publication number: 20110028720
    Abstract: The present invention is directed to compounds of the formula: or salts thereof or N-oxides and their use in peptide synthesis.
    Type: Application
    Filed: October 11, 2010
    Publication date: February 3, 2011
    Inventors: Louis A. Carpino, Jusong Xia, Chongwu Zhang, Calin Dan Sferdean
  • Coupling agents for peptide synthesis
    Patent number: 7812158
    Abstract: The present invention is directed to compounds of the formula (I) and (II) or salts thereof or N-oxides and their use in peptide synthesis.
    Type: Grant
    Filed: November 1, 2004
    Date of Patent: October 12, 2010
    Assignee: University of Massachusetts
    Inventors: Louis A. Carpino, Jusong Xia, Chongwu Zhang, Calin Dan Sferdean
  • New coupling agents for peptide synthesis
    Publication number: 20070112196
    Abstract: The present invention is directed to compounds of the formula (I) and (II) or salts thereof or N-oxides and their use in peptide synthesis.
    Type: Application
    Filed: November 1, 2004
    Publication date: May 17, 2007
    Inventors: Louis Carpino, Jusong Xia, Chongwu Zhang, Calin Sferdean
  • Uronium and immonium salts for peptide coupling
    Patent number: 6825347
    Abstract: The present invention is directed to salts of the formula: or N-oxides thereof, and their use in preparing an amide.
    Type: Grant
    Filed: May 21, 2002
    Date of Patent: November 30, 2004
    Assignee: Research Corporation Technologies, Inc.
    Inventors: Louis A. Carpino, Hideko Imazumi, Ayman El-Faham
  • Uronium and immonium salts for peptide coupling
    Publication number: 20030125561
    Abstract: The present invention is directed to salts of the formula: 1
    Type: Application
    Filed: May 21, 2002
    Publication date: July 3, 2003
    Inventors: Louis A. Carpino, Hideko Imazumi, Ayman El-Faham
  • Synthesis and use of amino acid fluorides as peptide coupling reagents
    Patent number: 6534627
    Abstract: The present invention is directed to the process of preparing a peptide comprising reacting a first amino acid or peptide with an amino acid fluoride of the formula: or the acid fluoride salts thereof wherein BLK is an N-amino protecting group; AA is an amino acid residue; and X is absent or a protecting group. The amino acid fluoride is useful as a coupling agent in peptide synthesis.
    Type: Grant
    Filed: February 23, 1999
    Date of Patent: March 18, 2003
    Assignee: Research Corporation Tecnologies, Inc.
    Inventors: Louis A. Carpino, Ayman Ahmed El-Faham
  • Method of peptide synthesis
    Patent number: 6204361
    Abstract: The present invention relates to a process for forming an N-&agr;-amino protected amino acid fluoride in situ by reacting an N-&agr;-amino protected amino acid with an ionic fluoride salt in the presence of a peptide coupling agent. It is also directed to the use of the amino acid fluoride thus formed in peptide synthesis.
    Type: Grant
    Filed: November 25, 1998
    Date of Patent: March 20, 2001
    Assignee: Research Corporation Technologies, Inc.
    Inventors: Louis A. Carpino, Dumitru Ionescu
  • Synthesis and use of amino acid fluorides as peptide coupling reagent
    Patent number: 6040422
    Abstract: The present invention is directed to a process for forming a peptide bond between a first amino acid having a free amino group and a protected carboxy group and a second amino acid or between a peptide having a free amino group and a blocking carboxy group with a second amino acid which comprises (a) reacting the second amino acid of the formula: ##STR1## with a fluoroformamidinium salt of the formula: ##STR2## and (b) reacting the product of (a) with the first amino acid or peptide.
    Type: Grant
    Filed: January 5, 1998
    Date of Patent: March 21, 2000
    Assignee: Research Corporation Technologies, Inc.
    Inventors: Louis A. Carpino, Ayman Ahmed El-Faham
  • Method of peptide synthesis
    Patent number: 5849954
    Abstract: The present invention relates to a process for forming an N-.alpha.-amino protected amino acid fluoride in situ by reacting an N-.alpha.-amino protected amino acid with an ionic fluoride salt in the presence of a peptide coupling agent. It is also directed to the use of the amino acid fluoride thus formed in peptide synthesis.
    Type: Grant
    Filed: January 18, 1996
    Date of Patent: December 15, 1998
    Assignee: Research Corporation Technologies, Inc.
    Inventors: Louis A. Carpino, Dumitru Ionesou
  • Synthesis and use of amino acid fluorides as peptide coupling reagents
    Patent number: 5750767
    Abstract: The present invention is directed to the process of preparing a peptide comprising reacting a first amino acid or peptide with an amino acid fluoride of the formula: ##STR1## or the acid fluoride salts thereof wherein BLK is an N-amino protecting groupAA is an amino acid residue andX is H or a protecting group useful,and the first amino and peptide have a free amino group and a blocked carboxy end.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: May 12, 1998
    Assignee: Research Corporation Technologies, Inc.
    Inventors: Louis A. Carpino, Ayman Ahmed El-Faham
  • Synthesis and use of amino acid fluorides as peptide coupling reagents
    Patent number: 5712418
    Abstract: The present invention is directed to the process of preparing a peptide comprising reacting a first amino acid or peptide with an amino acid fluoride of the formula: ##STR1## or the acid fluoride salts thereof wherein BLK is an N-amino protecting groupAA is an amino acid residue andX is H or a protecting group useful,and the first amino and peptide have a free amino group and a blocked carboxy end.
    Type: Grant
    Filed: August 2, 1994
    Date of Patent: January 27, 1998
    Assignee: Research Corporation Technologies, Inc.
    Inventors: Louis A. Carpino, Ayman Ahmed El-Faham
  • Reagents for peptide couplings
    Patent number: 5698675
    Abstract: This invention relates to a process for forming an amide or an ester from a reaction between an amine or an alcohol, respectively and an acylating derivative of a carboxylic acid, in the presence of an effective amount of a compound having the formula: ##STR1## and N-oxides thereof and salts thereof.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: December 16, 1997
    Assignee: Research Corporation Tech., Inc.
    Inventor: Louis A. Carpino
  • Reagents for peptide couplings
    Patent number: 5644029
    Abstract: This invention relates to a process for forming an amide or an ester from a reaction between an amine or an alcohol, respectively and an acylating derivative of a carboxylic acid, in the presence of an effective amount of a compound having the formula: ##STR1## and N-oxides thereof and salts thereof.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: July 1, 1997
    Assignee: Research Corporation Technologies, Inc.
    Inventor: Louis A. Carpino
  • Azahydroxybenzotriazoles and derivatives thereof for peptide coupling reactions
    Patent number: RE37686
    Abstract: This invention relates to a process for forming an amide or an ester from a reaction between an amine or an alcohol, respectively and an acylating derivative of a carboxylic acid, in the presence of an effective amount of a compound having the formula: and N-oxides thereof and salts thereof.
    Type: Grant
    Filed: December 3, 1998
    Date of Patent: April 30, 2002
    Assignee: Research Corporation Technologies, Inc.
    Inventor: Louis A. Carpino
  • Products for peptide coupling
    Patent number: RE38073
    Abstract: This invention relates to a process for forming an amide or an ester from a reaction between an amine or an alcohol, respectively and an acylating derivative of a carboxylic acid, in the presence of an effective amount of a compound having the formula: and N-oxides thereof and salts thereof.
    Type: Grant
    Filed: June 30, 1999
    Date of Patent: April 8, 2003
    Assignee: Research Corporations Technologies, Inc.
    Inventor: Louis A. Carpino