Abstract: The invention provides pyrazolylsulfonamide compounds, pharmaceutical compositions, their use for inhibiting mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1), and their use in the treatment of a disease or condition, such as a proliferative disorder, inflammatory disorder, or autoimmune disorder.

Abstract: The invention provides pyridinylsulfonamide compounds, pharmaceutical compositions, their use for inhibiting mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1), and their use in the treatment of a disease or condition, such as a proliferative disorder, inflammatory disorder, or autoimmune disorder.

Abstract: A method and apparatus for impregnating a porous foam product with a fragrance which is released over an extended period of time. The method includes the steps of depositing scented particles on one surface of the foam and dispersing the particles within the foam by supplying heat to the foam and applying a vacuum to the opposite surface of the foam. Fragrance or fragrance particles may also be added directly to the foam during its manufacture and a semi-permeable film or fabric may also be affixed to the scented porous foam product to retard and thus extend the release of the fragrance. In a preferred embodiment, frangible encapsulated particles of fragrance are used so that the encapsulated fragrance is retained within the foam until it is later utilized and subject to external forces which break the capsule to release the fragrance.