Abstract: The invention provides novel methods for preparing indolinobenzodiazepine dimer compounds and their synthetic precursors.

Abstract: A method for providing energy from waste heat from an electrolysis process to one or more commercial or industrial operations is provided. The method includes the steps of converting water to oxygen and a hydrogen product through an electrolysis process, wherein the hydrogen product has a carbon intensity less than about 0.45 kg CO2e/kg H2, and wherein at least some of the required energy for the electrolysis process is provided from a biomass power plant. The method further includes recovering waste heat from the electrolysis process, and then converting at least some of the waste heat to thermal energy for use in the one or more commercial or industrial operations. Examples of commercial and industrial operations includes, without limitation, greenhouses, algae farms, district cooling, and district heating.

Abstract: A method includes, at a controller, sensing a magnitude of a first force applied to the thumbstick in a substantially downward direction relative to a top portion of the housing while the thumbstick is in the stationary default position, and a magnitude of a second force applied to the thumbstick in the substantially downward direction relative to the top portion of the housing while the thumbstick is in a position other than the stationary default position. The method includes receiving the magnitude of the first and the second force, and determining whether the magnitude of the first force or the second force satisfies a predefined force value. The method further includes providing haptic feedback to the user in response to a determination that the magnitude of the first force or the second force satisfies the predefined force value.

Abstract: The invention relates to computer-implemented systems and methods for implementing a verified digital asset platform. An embodiment of the present invention is directed to enabling companies to provide professional recognition awards to employees utilizing digital assets, such as NFT (Non-Fungible Tokens). With an embodiment of the present invention, a digital wallet may store public and private keys and allow the owner to perform various actions including access assets, manage assets and sign transactions.

Abstract: The invention provides novel methods for preparing indolinobenzodiazepine monomer compounds and their synthetic precursors.

Abstract: The invention relates to novel benzodiazepine derivatives with antiproliferative activity and more specifically to novel benzodiazepine compounds of formulae (I), (II) and (III). The invention also provides conjugates of the benzodiazepine compounds linked to a cell-binding agent. The invention further provides compositions and methods useful for inhibiting abnormal cell growth or treating a proliferative disorder in a mammal using the compounds or conjugates of the invention.

Abstract: The invention provides novel methods for preparing substituted indoline compounds and their synthetic precursors.

Abstract: The invention relates to novel cell-binding agent-cytotoxic agent conjugates, wherein the cell-binding agent (CBA) is covalently linked to the cytotoxic agent through an aldehyde group obtained from oxidation of a 2-hydroxyethylamine moiety on the CBA. The invention also provides methods of preparing the conjugates of the present invention. The invention further provides composition and methods useful for inhibiting abnormal cell growth or treating a proliferative disorder in a mammal using the conjugates of the invention.

Abstract: The invention relates to novel methods for preparing indolinobenzodiazepine dimer compounds and their synthetic precursors.

Abstract: The invention relates to novel benzodiazepine derivatives with antiproliferative activity and more specifically to novel benzodiazepine compounds of formula (I)-(VI). The invention also provides conjugates of the benzodiazepine compounds linked to a cell-binding agent. The invention further provides compositions and methods useful for inhibiting abnormal cell growth or treating a proliferative disorder in a mammal using the compounds or conjugates of the invention.

Abstract: Methods and systems for reconnecting a device with an expired device operational certificate in a building management system (BMS) are disclosed. One method includes identifying that a device operational certificate of a first device has expired, sending an instruction to a second device to accept the expired device operational certificate as valid, receipt of the instruction causing the second device to relax an expiration date and accept the expired device operational certificate as valid, and delivering a replacement device operational certificate to the first device to replace the expired device operational certificate.

Abstract: The invention relates to benzodiazepine derivatives with antiproliferative activity and more specifically to benzodiazepine compounds of formulae (I), (II), (TI) and (T2). The invention also provides conjugates of the benzodiazepine compounds linked to a cell-binding agent. The invention further provides compositions and methods for inhibiting abnormal cell growth or treating a proliferative disorder in a mammal using the compounds or conjugates of the invention.

Abstract: The invention provides novel methods for preparing indolinobenzodiazepine dimer compounds and their synthetic precursors.

Abstract: The invention relates to novel benzodiazepine derivatives with antiproliferative activity and more specifically to novel benzodiazepines of formula (I) and (II), in which the diazepine ring (B) is fused with a heterocyclic ring (CD), wherein the heterocyclic ring is bicyclic or a compound of formula (III), in which the diazepine ring (B) is fused with a heterocyclic ring (C), wherein the heterocyclic ring is monocyclic. The invention provides cytotoxic dimers of these compounds. The invention also provides conjugates of the monomers and the dimers. The invention further provides compositions and methods useful for inhibiting abnormal cell growth or treating a proliferative disorder in a mammal using the compounds or conjugates of the invention. The invention further relates to methods of using the compounds or conjugates for in vitro, in situ, and in vivo diagnosis or treatment of mammalian cells, or associated pathological conditions.

Abstract: The invention relates to novel methods for preparing indolinobenzodiazepine dimer compounds and their synthetic precursors.

Abstract: The invention provides novel methods for preparing indolinobenzodiazepine dimer compounds and their synthetic precursors.

Abstract: A turbo machine, a computer-implemented method, and a computer system for operating a compressor assembly are provided. The method includes comparing a first data set and a second data set to determine a first correlation factor, comparing the first correlation factor to a first threshold that at least partially determines whether a stall precursor exists, removing mean values from the first data set and the second data set, comparing the first data set and the second data set each removed of mean values to determine a second correlation factor, and comparing the second correlation factor to the first threshold, and classifying the stall precursor as either a spike stall precursor, a modal stall precursor, or a combination stall precursor.

Abstract: A turbo machine, a computer-implemented method, and a computer system for operating a compressor assembly are provided. The method includes comparing a first data set and a second data set to determine a first correlation factor, comparing the first correlation factor to a first threshold that at least partially determines whether a stall precursor exists, removing mean values from the first data set and the second data set, comparing the first data set and the second data set each removed of mean values to determine a second correlation factor, and comparing the second correlation factor to the first threshold, and classifying the stall precursor as either a spike stall precursor, a modal stall precursor, or a combination stall precursor.

Abstract: The invention relates to novel cell-binding agent-cytotoxic agent conjugates, wherein the cell-binding agent (CBA) is covalently linked to the cytotoxic agent through an aldehyde group obtained from oxidation of a 2-hydroxyethylamine moiety on the CBA. The invention also provides methods of preparing the conjugates of the present invention. The invention further provides composition and methods useful for inhibiting abnormal cell growth or treating a proliferative disorder in a mammal using the conjugates of the invention.

Abstract: The invention relates to novel benzodiazepine derivatives with antiproliferative activity and more specifically to novel benzodiazepine compounds of formula (I)-(VII). The invention also provides conjugates of the benzodiazepine compounds linked to a cell-binding agent. The invention further provides compositions and methods useful for inhibiting abnormal cell growth or treating a proliferative disorder in a mammal using the compounds or conjugates of the invention.