Abstract: The present invention provides cyclic nitro compound, pharmaceutical compositions of cyclic nitro compounds and methods of using cyclic nitro compounds and/or pharmaceutical compositions thereof to treat or prevent diseases or disorders characterized by abnormal cell proliferation, such as cancer, inflammation, cardiovascular disease and autoimmune disease.

Abstract: Medical devices and methods for making and using medical devices are disclosed. An example medical device may include a guide extension catheter. The guide extension catheter may include a proximal member having a proximal end, a distal end, and a proximal diameter. The guide extension catheter may additionally include a collar member attached to an extension portion of the proximal member, where the extension portion may be located at the distal end of the proximal member. The extension portion may allow a delivery device to be inserted through the guide extension catheter to extend along a surface of the extension portion and align with a lumen of a distal sheath of the guide extension catheter.

Abstract: Medical devices and methods for making and using medical devices are disclosed. An example medical device may include a guide extension catheter. The guide extension catheter may include a proximal member having a proximal end, a distal end, and a proximal diameter. The guide extension catheter may additionally include a collar member attached to an extension portion of the proximal member, where the extension portion may be located at the distal end of the proximal member. The extension portion may allow a delivery device to be inserted through the guide extension catheter to extend along a surface of the extension portion and align with a lumen of a distal sheath of the guide extension catheter.

Abstract: Medical devices and methods for making and using medical devices are disclosed. An example medical device may include a guide extension catheter. The guide extension catheter may include a proximal shaft having a first outer diameter. A distal sheath may be attached to the proximal shaft and may have a second outer diameter greater than the first outer diameter. The distal sheath may be designed to extend past a coronary ostium and into a coronary artery so that another medical device can pass therethrough toward the coronary artery. An expandable balloon may be coupled to the distal sheath.

Abstract: Medical devices and methods for making and using medical devices are disclosed. An example medical device may include a guide extension catheter. The guide extension catheter may include a proximal member having a proximal end, a distal end, and a proximal diameter. The guide extension catheter may additionally include a collar member attached to an extension portion of the proximal member, where the extension portion may be located at the distal end of the proximal member. The extension portion may allow a delivery device to be inserted through the guide extension catheter to extend along a surface of the extension portion and align with a lumen of a distal sheath of the guide extension catheter.

Abstract: Medical devices and methods for making and using medical devices are disclosed. An example medical device may include a guide extension catheter. The guide extension catheter may include a proximal member having a proximal end, a distal end, and a proximal diameter. The guide extension catheter may additionally include a collar member attached to an extension portion of the proximal member, where the extension portion may be located at the distal end of the proximal member. The extension portion may allow a delivery device to be inserted through the guide extension catheter to extend along a surface of the extension portion and align with a lumen of a distal sheath of the guide extension catheter.

Abstract: A guide extension catheter may include a proximal shaft and a tubular distal sheath including an exchange channel allowing for access (e.g. side access) into the lumen. Guide extension catheters may be used in conjunction with a guide catheter and a medical device having a distal region disposed within the guide catheter and a proximal region disposed outside of the guide catheter. A portion of the proximal region of the medical device can be passed through the exchange channel and into the lumen, and the guide extension catheter can be advanced into the guide catheter over the medical device without removing the medical device from the guide catheter. The exchange channel can extend in a straight line path along the sheath, or may extend in an indirect path along the sheath.

Abstract: Systems and techniques are provided for security system re-arming. Input invoking restricted credentials may be received. The security system of an environment may be changed from a first mode to a second mode based on the restricted credentials. The restricted credentials used to change the security system to the second mode may be determined to be near expiration based on an expiration condition of the restricted credentials. A notification may be sent to a person associated with the restricted credentials including a reminder to use the restricted credentials to change the security system to the first mode before the restricted credentials expire.

Abstract: Systems and techniques are provided for security system re-arming. Input invoking restricted credentials may be received. The security system of an environment may be changed from a first mode to a second mode based on the restricted credentials. The restricted credentials used to change the security system to the second mode may be determined to be near expiration based on an expiration condition of the restricted credentials. A notification may be sent to a person associated with the restricted credentials including a reminder to use the restricted credentials to change the security system to the first mode before the restricted credentials expire.

Abstract: Medical devices and methods for making and using medical devices are disclosed. An example medical device may include a guide extension catheter. The guide extension catheter may include a proximal member having a proximal end, a distal end, and a proximal diameter. The guide extension catheter may additionally include a collar member attached to an extension portion of the proximal member, where the extension portion may be located at the distal end of the proximal member. The extension portion may allow a delivery device to be inserted through the guide extension catheter to extend along a surface of the extension portion and align with a lumen of a distal sheath of the guide extension catheter.

Abstract: Systems and techniques are provided for security system re-arming. Input invoking restricted credentials may be received. The security system of an environment may be changed from a first mode to a second mode based on the restricted credentials. The restricted credentials used to change the security system to the second mode may be determined to be near expiration based on an expiration condition of the restricted credentials. A notification may be sent to a person associated with the restricted credentials including a reminder to use the restricted credentials to change the security system to the first mode before the restricted credentials expire.

Abstract: Medical devices and methods for making and using medical devices are disclosed. An example medical device may include a guide extension catheter. The guide extension catheter may include a proximal shaft having a first outer diameter. A distal sheath may be attached to the proximal shaft and may have a second outer diameter greater than the first outer diameter. The distal sheath may be designed to extend past a coronary ostium and into a coronary artery so that another medical device can pass therethrough toward the coronary artery. An expandable balloon may be coupled to the distal sheath.

Abstract: Systems and techniques are provided for security system re-arming. Input invoking restricted credentials may be received. The security system of an environment may be changed from a first mode to a second mode based on the restricted credentials. The restricted credentials used to change the security system to the second mode may be determined to be near expiration based on an expiration condition of the restricted credentials. A notification may be sent to a person associated with the restricted credentials including a reminder to use the restricted credentials to change the security system to the first mode before the restricted credentials expire.

Abstract: A sheath assembly for protecting an endoscope insertion tube projecting from an endoscope head. The sheath assembly comprises: a resilient elongate tube comprising a bore for receiving the endoscope insertion tube; a resilient fitting for gripping the endoscope head; and a connector comprising a proximal end attached to the resilient fitting and a distal end attached to the tube. The connector and the resilient fitting are formed from different materials, the material forming the connector having a higher elastic modulus than the material forming the resilient fitting. The higher stiffness of the connector enables it to transmit axial forces evenly and efficiently to the fitting. The connector has a pair of laterally extending wings which provide a convenient and ergonomic point to grip the connector, making it easier to fit the assembly onto the endoscope head.

Abstract: A navigational plotter which generally comprises a rectangular elongated member comprising two straight edges and having a circular protractor rotatably secured thereto in the geometric center. The rectangular elongated member has a plurality of distance scales formed along and adjacent to each of the two opposite longitudinal straight edges thereof. These distance scales correspond to, for example, statute miles, nautical miles or kilometers, and each scale is spaced apart from the other to provide between adjacent scales a clear, unobstructed course line window which permits the navigational plotter to be placed over or adjacent to a course line on a chart without obscuring it. The scales along one longitudinal straight edge of the navigational plotter can correspond to the scaling of, for example, sectional charts, while those along the opposite longitudinal straight edge can correspond to, for example, the scaling of the WAC charts.