Patents by Inventor Louis A. Zumstein

Louis A. Zumstein has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PROGNOSTIC FACTORS FOR ANTI-HYPERPROLIFERATIVE DISEASE GENE THERAPY
    Publication number: 20070231304
    Abstract: The present invention relates to the identification of various prognostic factors that predict response in patients with hyperproliferative disease such as cancer to gene therapy, and their use in methods of treating such patients with an anti-hyperproliferative disease gene therapy. Also described are methods of treatment for Li Fraumeni syndrome, and for assessing anti-cancer gene therapy using PET scans.
    Type: Application
    Filed: January 30, 2007
    Publication date: October 4, 2007
    Inventors: Robert Sobol, Sunil Chada, Louis Zumstein, Esteban Cvitkovic, Kerstin Menander
  • Adenoviral p53 gene transfer in the prevention and treatment of injury-induced vascular smooth muscle cell proliferation
    Publication number: 20030223967
    Abstract: The present invention provides for the use of expression constructs encoding the tumor suppressor p53 for the prevention or treatment of vascular stenosis caused by vascular smooth muscle cell (VSMC) proliferation and/or migration in response to vascular trauma. This p53 therapy may be used in conjunction with other therapies including secondary gene therapy, anti-thrombotics or anti-inflammatory agents.
    Type: Application
    Filed: May 9, 2003
    Publication date: December 4, 2003
    Inventors: Louis Zumstein, Sunil Chada
  • Senscent cell-derived inhibitors of DNA synthesis
    Patent number: 6372249
    Abstract: The use of liposomal formulations, particularly formulations of positively charged and neutral lipids facilitates cellular uptake of SDI molecules. The transcription and/or expression of SDI-1-encoding nucleic acid molecules is facilitated by constructs that contain intervening untranslated regions.
    Type: Grant
    Filed: October 24, 1994
    Date of Patent: April 16, 2002
    Assignee: Baylor College of Medicine
    Inventors: James R. Smith, David J. Drutz, Deborah R. Wilson, Louis A. Zumstein