Patents by Inventor Louis Barash

Louis Barash has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND METHODS FOR TREATING PULMONARY ARTERIAL HYPERTENSION (PAH) AND OTHER DISORDERS
    Publication number: 20240110190
    Abstract: Compositions and methods for treating fibrosis using oligonucleotide-based therapies are provided. These therapies can be used to increase expression of Bone morphogenetic protein receptor type II (BMPR2) via inhibition of upstream Open Reading Frames, thereby reducing vasoconstriction, vascular remodeling, and formation of fibrosis, particularly pulmonary arterial fibrosis related in patients in need thereof.
    Type: Application
    Filed: February 28, 2022
    Publication date: April 4, 2024
    Applicant: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
    Inventors: Yoseph BARASH, David Sheng Ming LEE, Louis R. GHANEM, Nicholas J. HAND
  • N-acyl derivatives of thienamycin
    Patent number: 4839352
    Abstract: Disclosed are N-acyl derivatives of the antibiotic thienamycin having the following structural formula: ##STR1## wherein R.sup.1 and R.sup.2 are independently selected from the group consisting of hydrogen and acyl. Such derivatives and their pharmaceutically acceptable salts, are useful as antibiotics. Also disclosed are processes for the preparation of such derivatives, pharmaceutical compositions comprising such derivatives, and methods of treatment comprising administering such derivatives and compositions when an antibiotic effect is indicated.
    Type: Grant
    Filed: August 27, 1987
    Date of Patent: June 13, 1989
    Assignee: Merck & Co., Inc.
    Inventors: Louis Barash, Burton G. Christensen, John Hannah, William J. Leanza, David H. Shih
  • Dipeptidase inhibitors
    Patent number: 4406902
    Abstract: Novel chemical compounds are provided which selectively inhibit the metabolism of dipeptidase (E.C.3.4.13.11) and therefore are useful in combination with antibacterial products. These chemical compounds are Z-2-(2,2-dimethylcyclo-propanecarboxamido)-.omega.-pyridylthio-2-alkenoic acids (and related arylthio and heterocyclylthio analogs).
    Type: Grant
    Filed: July 23, 1981
    Date of Patent: September 27, 1983
    Assignee: Merck & Co., Inc.
    Inventors: Wallace T. Ashton, Louis Barash, Jeannette E. Brown, Donald W. Graham