Abstract: An imaging assembly for use in a medical imaging device such as an endoscope or the like. In one embodiment, the imaging assembly includes a transparent distal cap that is shaped to receive an image sensor insert. The image sensor insert has a cooling channel that supplies a cooling liquid or gas to one or more illumination sources.

Abstract: A medical device and system capable of providing on-demand delivery of biologically active material to a body lumen patient, and a method of making such medical device. A first coating layer comprising a biologically active material and optionally a polymeric material is disposed on the surface of the medical device. A second coating layer comprising magnetic particles and a polymeric material is disposed on the first coating layer. The second coating layer, which is substantially free of a biologically active material, protects the biologically active material prior to delivery. The system includes the medical device and a source of energy, such as an electromagnetic or mechanical vibrational energy. When the patient is exposed to the energy source, the magnetic particles move out of the second coating layer and create channels therein through which the biologically active material can be released.

Abstract: An improved Optical Coherence Domain Reflectometry (OCDR) system is provided. One embodiment of this OCDR system outputs a detector signal carrying image depth information on multiple modulation frequencies, where each modulation frequency corresponds to a different image depth. The image depth information from the detector signal may be resolved by tuning to the desired modulation frequency. Another system for imaging body tissue uses multiple frequency modulators such that the light beam does not travel from an optical fiber to free space.

Abstract: A steerable endoscopic sheath has a proximal end, a distal end and a working channel lumen disposed therein. A plurality of solid state light emitting devices such as light emitting diodes are positioned near the distal end of the sheath and are selectively energized to illuminate internal body tissues. An imaging device such as a photo diode or CCD array creates an image from light reflected from the tissue. The distal tip of the endoscopic sheath is selectively moveable with a deflection device that is insertable into the sheath. The deflection device includes a tip deflection mechanism that allows a user to move the tip of the deflection device. With the deflection device inserted in the sheath, movement of the distal tip causes a corresponding movement in the distal tip of the sheath. The distal tip of the sheath has a shape retaining mechanism that allows it to retain the shape imparted by the deflection device once the deflection device is removed from the sheath.

Abstract: A disposable imaging catheter that produces high resolution, color images comparable to those obtained from an endoscope. The device may also be made to function as a guidewire. The device may also include a sheath which slides over the catheter body for stiffening and which may include a working channel for accepting interventional devices, as well as LEDs to illuminate the field of view. The vision catheter system includes a detector assembly, scanning mechanism, and distal objective lens. In one embodiment, a photodetector is mated to a lens/pinhole assembly that allows the detector to read light from a small discrete point. This assembly is then scanned in raster or spiral patterns via electric wire coils that actuate a magnetic scan plate to read the area of interest.

Abstract: A medical device such as a catheter or endoscope device includes an illumination light source having one or more organic light-emitting diodes (OLEDs). The OLEDs are energized to produce illumination light that is received by an image sensor or camera to produce images of tissue within a patient's body. A heat conductive polymer conducts heat away from the illumination light source.

Abstract: A system for measuring internal body cavities of a patient includes an interferometer having a reference leg and a patient leg that is inserted in the patient. The patient leg directs a beam of coherent light within a body cavity of the patient. Light exiting the patient leg is reflected by a tissue wall and is received by the patient leg where it is combined with light that is reflected through the reference leg. The light in the reference leg and patient leg combines to create fringes indicative of a difference in the optical path length between the two legs. A processor computes the dimensions of the body cavity from the difference in optical path length between the patient leg and the reference leg.

Abstract: An imaging transducer assembly is combined with a sensor of a medical positioning system, forming a transducer/sensor assembly. In one embodiment, the sensor includes a coil proximally coupled with the imaging transducer. A cable having first and second wires are proximally coupled to the coil. A non-conductive potting layer is wrapped around the coil. Traces are formed in the non-conductive potting layer that are used to electrically couple the imaging transducer with the first and second wires of the cable.

Abstract: A catheter with a small optical fiber or bundle of fibers includes a scanning mechanism constructed with the use of any vibration capable component. Magnetic, piezoelectric or other mechanisms are used to vibrate the end of the fiber and thus create a scanning effect which extends the field of view. This configuration can be used in a catheter with a relatively small diameter. A glass lens or lenses placed in front of the fiber focuses and magnifies the image. A CCD, CMOS, or photodiode camera at the proximal end of the fiber captures the image and transfers it to a computer or processor. A light splitter coupled to a light source provides light through an illumination fiber. The resulting vision catheter is relatively inexpensive and disposable.

Abstract: A catheter with a small optical fiber or bundle of fibers includes a scanning mechanism constructed with the use of any vibration capable component. Magnetic, piezoelectric or other mechanisms are used to vibrate the end of the fiber and thus create a scanning effect which extends the field of view. One or more lenses may be utilized, including a lens attached to the distal tip of the image fiber, or a lens attached to the distal tip of the catheter for creating an image plane which can be scanned by the fiber. In one embodiment, multiple light sources may be connected to the fiber for enabling the use of field sequential color techniques for real-time imaging, as well as real-time fluorescent imaging for disease detection. A photodetector assembly connected to the proximal end may contain both filtered and unfiltered detectors for use with both standard imaging and fluorescent imaging. The resulting vision catheter is relatively inexpensive and disposable.