Patents by Inventor Louis Bonhomme
Louis Bonhomme has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9897520Abstract: Sample preparation device that allows for a complete bind, wash, elute, buffer-exchange and concentration process to be carried out without sample transfer between multiple devices. The device includes a reservoir, a column for holding chromatography media, a holder region for holding a filtration device, and an outlet. The filtration device plugs into the holder region of the centrifugal device, and the assembly can be placed in an optional holder. The assembly, with or without the optional holder, can be placed in a conventional centrifuge tube for centrifugation. The entire bind, wash, elute, buffer exchange and concentration steps can be carried out with the apparatus without any pipette transfers (and the associated sample losses. The sample preparation device also can be used for binding and washing steps, in which case the filtration device is not needed, and for buffer exchange and concentration steps, in which case the media is not needed.Type: GrantFiled: December 18, 2015Date of Patent: February 20, 2018Assignee: EMD Millipore CorporationInventors: Christopher A. Scott, Timothy K. Nadler, Kurt Greenizen, Louis Bonhomme, Sara D. Gutierrez, Masaharu Mabuchi, David Briggs, Phillip Clark, Ralph T. Scaduto
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Publication number: 20160103045Abstract: Sample preparation device that allows for a complete bind, wash, elute, buffer-exchange and concentration process to be carried out without sample transfer between multiple devices. The device includes a reservoir, a column for holding chromatography media, a holder region for holding a filtration device, and an outlet. The filtration device plugs into the holder region of the centrifugal device, and the assembly can be placed in an optional holder. The assembly, with or without the optional holder, can be placed in a conventional centrifuge tube for centrifugation. The entire bind, wash, elute, buffer exchange and concentration steps can be carried out with the apparatus without any pipette transfers (and the associated sample losses. The sample preparation device also can be used for binding and washing steps, in which case the filtration device is not needed, and for buffer exchange and concentration steps, in which case the media is not needed.Type: ApplicationFiled: December 18, 2015Publication date: April 14, 2016Inventors: Christopher A. Scott, Timothy K. Nadler, Kurt Greenizen, Louis Bonhomme, Sara D. Gutierrez, Masaharu Mabuchi, David Briggs, Phillip Clark, Ralph T. Scaduto
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Patent number: 9304070Abstract: Sample preparation device that allows for a complete bind, wash, elute, buffer-exchange and concentration process to be carried out without sample transfer between multiple devices. The device includes a reservoir, a column for holding chromatography media, a holder region for holding a filtration device, and an outlet. The filtration device plugs into the holder region of the centrifugal device, and the assembly can be placed in an optional holder. The assembly, with or without the optional holder, can be placed in a conventional centrifuge tube for centrifugation. The entire bind, wash, elute, buffer exchange and concentration steps can be carried out with the apparatus without any pipette transfers (and the associated sample losses. The sample preparation device also can be used for binding and washing steps, in which case the filtration device is not needed, and for buffer exchange and concentration steps, in which case the media is not needed.Type: GrantFiled: June 27, 2012Date of Patent: April 5, 2016Assignee: EMD Millipore CorporationInventors: Christopher A. Scott, Timothy K. Nadler, Kurt Greenizen, Louis Bonhomme, Sara D. Gutierrez, Masaharu Mabuchi, David Briggs, Phillip Clark, Ralph T. Scaduto
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Patent number: 9295947Abstract: Filtration device suited for concentration of liquid samples, particularly biomolecules, and a method of concentrating, desalting, purifying and/or fractionating liquid samples. In certain embodiments the device includes a housing having a sample reservoir, and two substantially vertically oriented and spaced apart membranes disposed in the housing. An underdrain is associated with each membrane such that fluid passing through each membrane flows through a respective underdrain into a filtrate collection chamber. The fluid that does not pass through the membrane is collected in the retentate collection chamber, and can be recovered such as by a reverse spinning step, achieving recoveries greater than about 90%. The substantially vertical orientation of the membranes increases the available membrane area by at least 2.7 times the area available in a conventional filter device.Type: GrantFiled: February 26, 2014Date of Patent: March 29, 2016Assignee: EMD Millipore CorporationInventors: Louis Bonhomme, John Doyle, Kurt Greenizen, George Gagne, Sean Devin, Gerard Lombard, Vincent Smith
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Patent number: 9103756Abstract: Sample preparation device that allows for a complete bind, wash, elute, buffer-exchange and concentration process to be carried out without sample transfer between multiple devices. The device includes a reservoir, a column for holding chromatography media, a holder region for holding a filtration device, and an outlet. The filtration device plugs into the holder region of the centrifugal device, and the assembly can be placed in an optional holder. The assembly, with or without the optional holder, can be placed in a conventional centrifuge tube for centrifugation. The entire bind, wash, elute, buffer exchange and concentration steps can be carried out with the apparatus without any pipette transfers (and the associated sample losses. The sample preparation device also can be used for binding and washing steps, in which case the filtration device is not needed, and for buffer exchange and concentration steps, in which case the media is not needed.Type: GrantFiled: September 19, 2013Date of Patent: August 11, 2015Assignee: EMD Millipore CorporationInventors: Christopher A. Scott, Timothy K. Nadler, Kurt Greenizen, Louis Bonhomme, Sara D. Gutierrez, Masaharu Mabuchi, David Briggs, Phillip Clark, Ralph T. Scaduto
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Patent number: 9050565Abstract: Filtration device suited for concentration of liquid samples, particularly biomolecules, and a method of concentrating, desalting, purifying and/or fractionating liquid samples. In certain embodiments the device includes a housing having a sample reservoir, and two substantially vertically oriented and spaced apart membranes disposed in the housing. An underdrain is associated with each membrane such that fluid passing through each membrane flows through a respective underdrain into a filtrate collection chamber. The fluid that does not pass through the membrane is collected in the retentate collection chamber, and can be recovered such as by a reverse spinning step, achieving recoveries greater than about 90%. The substantially vertical orientation of the membranes increases the available membrane area by at least 2.7 times the area available in a conventional filter device.Type: GrantFiled: January 11, 2013Date of Patent: June 9, 2015Assignee: EMD Millipore CorporationInventors: Louis Bonhomme, John Doyle, Kurt Greenizen, George Gagne, Sean Devin, Gerard Lombard, Vincent Smith
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Publication number: 20140224723Abstract: Filtration device suited for concentration of liquid samples, particularly biomolecules, and a method of concentrating, desalting, purifying and/or fractionating liquid samples. In certain embodiments the device includes a housing having a sample reservoir, and two substantially vertically oriented and spaced apart membranes disposed in the housing. An underdrain is associated with each membrane such that fluid passing through each membrane flows through a respective underdrain into a filtrate collection chamber. The fluid that does not pass through the membrane is collected in the retentate collection chamber, and can be recovered such as by a reverse spinning step, achieving recoveries greater than about 90%. The substantially vertical orientation of the membranes increases the available membrane area by at least 2.7 times the area available in a conventional filter device.Type: ApplicationFiled: February 26, 2014Publication date: August 14, 2014Applicant: EMD Millipore CorporationInventors: Louis Bonhomme, John Doyle, Kurt Greenizen, George Gagne, Sean Devin, Gerard Lombard, Vincent Smith
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Patent number: 8747670Abstract: Filtration device suited for concentration of liquid samples, particularly biomolecules, and a method of concentrating, desalting, purifying and/or fractionating liquid samples. In certain embodiments the device includes a housing having a sample reservoir, and two substantially vertically oriented and spaced apart membranes disposed in the housing. An underdrain is associated with each membrane such that fluid passing through each membrane flows through a respective underdrain into a filtrate collection chamber. The fluid that does not pass through the membrane is collected in the retentate collection chamber, and can be recovered such as by a reverse spinning step, achieving recoveries greater than about 90%. The substantially vertical orientation of the membranes increases the available membrane area by at least 2.7 times the area available in a conventional filter device.Type: GrantFiled: October 11, 2012Date of Patent: June 10, 2014Assignee: EMD Millipore CorporationInventors: Louis Bonhomme, John Doyle, Kurt Greenizen, George Gagne, Sean Devin, Gerard Lombard, Vincent Smith
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Publication number: 20140017151Abstract: Sample preparation device that allows for a complete bind, wash, elute, buffer-exchange and concentration process to be carried out without sample transfer between multiple devices. The device includes a reservoir, a column for holding chromatography media, a holder region for holding a filtration device, and an outlet. The filtration device plugs into the holder region of the centrifugal device, and the assembly can be placed in an optional holder. The assembly, with or without the optional holder, can be placed in a conventional centrifuge tube for centrifugation. The entire bind, wash, elute, buffer exchange and concentration steps can be carried out with the apparatus without any pipette transfers (and the associated sample losses. The sample preparation device also can be used for binding and washing steps, in which case the filtration device is not needed, and for buffer exchange and concentration steps, in which case the media is not needed.Type: ApplicationFiled: September 19, 2013Publication date: January 16, 2014Applicant: EMD Millipore CorporationInventors: Christopher A. Scott, Timothy K. Nadler, Kurt Greenizen, Louis Bonhomme, Sara D. Gutierrez, Masaharu Mabuchi, David Briggs, Phillip Clark, Ralph T. Scaduto
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Patent number: 8357296Abstract: Filtration device suited for concentration of liquid samples, particularly biomolecules, and a method of concentrating, desalting, purifying and/or fractionating liquid samples. In certain embodiments the device includes a housing having a sample reservoir, and two substantially vertically oriented and spaced apart membranes disposed in the housing. An underdrain is associated with each membrane such that fluid passing through each membrane flows through a respective underdrain into a filtrate collection chamber. The fluid that does not pass through the membrane is collected in the retentate collection chamber, and can be recovered such as by a reverse spinning step, achieving recoveries greater than about 90%. The substantially vertical orientation of the membranes increases the available membrane area by at least 2.7 times the area available in a conventional filter device.Type: GrantFiled: September 24, 2007Date of Patent: January 22, 2013Assignee: EMD Millipore CorporationInventors: Louis Bonhomme, John Doyle, Kurt Greenizen, George Gagne, Sean Devin, Gerard Lombard, Vincent Smith, Mark Kavonian
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Publication number: 20130017620Abstract: Sample preparation device that allows for a complete bind, wash, elute, buffer-exchange and concentration process to be carried out without sample transfer between multiple devices. The device includes a reservoir, a column for holding chromatography media, a holder region for holding a filtration device, and an outlet. The filtration device plugs into the holder region of the centrifugal device, and the assembly can be placed in an optional holder. The assembly, with or without the optional holder, can be placed in a conventional centrifuge tube for centrifugation. The entire bind, wash, elute, buffer exchange and concentration steps can be carried out with the apparatus without any pipette transfers (and the associated sample losses. The sample preparation device also can be used for binding and washing steps, in which case the filtration device is not needed, and for buffer exchange and concentration steps, in which case the media is not needed.Type: ApplicationFiled: June 27, 2012Publication date: January 17, 2013Applicant: EMD MILLIPORE CORPORATIONInventors: Christopher A. Scott, Timothy K. Nadler, Kurt Greenizen, Louis Bonhomme, Sara D. Gutierrez, Masaharu Mabuchi, David Briggs, Phillip Clark, Ralph T. Scaduto
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Patent number: 7806274Abstract: The present invention is a filter assembly for vacuum filtration formed of a housing having an upper portion and lower portion, a filter separating the upper from the lower portion of the housing, an inlet formed in the upper housing, an outlet and a vacuum port formed in the lower portion, a gasket arranged at a lowermost surface of the lower portion and the upper portion is having a height sufficient to trap any air that might enter and keep it away from the membrane surface. Preferably, it is of a curved shape, preferably in the form of a dome. Optionally, the upper portion of the housing may also contain a vent, particularly a vent controlled by a valve, for the removal of air periodically from the upper portion, especially when a large incursion of air has occurred.Type: GrantFiled: February 2, 2004Date of Patent: October 5, 2010Assignee: Millipore CorporationInventors: Chris A. Scott, Matthew John Dunleavy, Louis Bonhomme
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Publication number: 20090078638Abstract: Filtration device suited for concentration of liquid samples, particularly biomolecules, and a method of concentrating, desalting, purifying and/or fractionating liquid samples. In certain embodiments the device includes a housing having a sample reservoir, and two substantially vertically oriented and spaced apart membranes disposed in the housing. An underdrain is associated with each membrane such that fluid passing through each membrane flows through a respective underdrain into a filtrate collection chamber. The fluid that does not pass through the membrane is collected in the retentate collection chamber, and can be recovered such as by a reverse spinning step, achieving recoveries greater than about 90%. The substantially vertical orientation of the membranes increases the available membrane area by at least 2.7 times the area available in a conventional filter device.Type: ApplicationFiled: September 24, 2007Publication date: March 26, 2009Inventors: Louis Bonhomme, John Doyle, Kurt Geenizen, George Gagne, Sean Devin, Gerard Lombard, Vincent Smith
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Publication number: 20050051471Abstract: The present invention provides an underdrain having an improved spout. The underdrain has particular utility in the construction of both single-well and microarray filtration devices. In a principal embodiment, the underdrain is characterized by its incorporation of a straight-walled, roughly-textured spout, the spout being provided with microhole(s) at a terminal end thereof for the discharge of fluid conducted through the underdrain. An array comprising several of such underdrains can be mated with a corresponding array of wells, with separation material (e.g., membrane material) provided therebetween. The resultant microarray filtration device can be used for conducting several fluid assays contemporaneously with, for example, good “pendant drop” control and low “cross-talk”.Type: ApplicationFiled: September 4, 2003Publication date: March 10, 2005Inventors: Joseph Lane, Louis Bonhomme, Douglas Boucher, Richard Burnham, Kenneth Desilets, Luc Lirot, Stephane Olivier, Steven Sheridan
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Publication number: 20040188344Abstract: The present invention is a filter assembly for vacuum filtration formed of a housing having an upper portion and lower portion, a filter separating the upper from the lower portion of the housing, an inlet formed in the upper housing, an outlet and a vacuum port formed in the lower portion, a gasket arranged at a lowermost surface of the lower portion and the upper portion is having a height sufficient to trap any air that might enter and keep it away from the membrane surface. Preferably, it is of a curved shape, preferably in the form of a dome. Optionally, the upper portion of the housing may also contain a vent, particularly a vent controlled by a valve, for the removal of air periodically from the upper portion, especially when a large incursion of air has occurred.Type: ApplicationFiled: February 2, 2004Publication date: September 30, 2004Inventors: Chris A. Scott, Matthew John Dunleavy, Louis Bonhomme