Patents by Inventor Louis Brammer Hansen

Louis Brammer Hansen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for producing acylated peptides
    Patent number: 9562910
    Abstract: The present invention provides a method for acylating one or more amino groups of a peptide where the acylation reaction is to be performed in an aqueous mixture containing less than 10% w/w aprotic polar solvent.
    Type: Grant
    Filed: January 4, 2010
    Date of Patent: February 7, 2017
    Assignee: Novo Nordisk A/S
    Inventors: Dorte Lunoe Dunweber, Inge Holm Jensen, Louis Brammer Hansen
  • Method For Producing Acylated Peptides
    Publication number: 20100105863
    Abstract: The present invention provides a method for acylating one or more amino groups of a peptide where the acylation reaction is to be performed in an aqueous mixture containing less than 10% w/w aprotic polar solvent.
    Type: Application
    Filed: January 4, 2010
    Publication date: April 29, 2010
    Applicant: Novo Nordisk A/S
    Inventors: Dorte Lunoe Dunweber, Inge Holm Jensen, Louis Brammer Hansen
  • Method for producing acylated peptides
    Patent number: 7273921
    Abstract: The present invention provides a method for acylating one or more amino groups of a peptide where the acylation reaction is to be performed in an aqueous mixture containing less than 10% w/w aprotic polar solvent.
    Type: Grant
    Filed: September 25, 2003
    Date of Patent: September 25, 2007
    Assignee: Novo Nordisk A/S
    Inventors: Dorte Lunoe Dunweber, Inge Holm Jensen, Louis Brammer Hansen
  • Method for producing acylated peptides
    Publication number: 20040115759
    Abstract: The present invention provides a method for acylating one or more amino groups of a peptide where the acylation reaction is to be performed in an aqueous mixture containing less than 10% w/w aprotic polar solvent.
    Type: Application
    Filed: September 25, 2003
    Publication date: June 17, 2004
    Inventors: Dorte Lunoe Dunweber, Inge Holm Jensen, Louis Brammer Hansen
  • Method of acylating peptides and novel acylating agents
    Patent number: 6451974
    Abstract: Provided is a method for acylating one or more amino groups of a peptide or protein such as GLP-1. This method includes (a) reacting a peptide or protein having at least one free amino group with an acylating agent of formula I wherein n is 0-8; R1 is COOR4; R2 is a lipophilic moiety; R3 and its attached carboxyl group designate a reactive ester or a reactive N-hydroxy imide ester; and R4 is selected from hydrogen, C1-12-alkyl and benzyl, under basic conditions in a mixture of an aprotic polar solvent and water; and (b) if R4 is not hydrogen, saponifying the acylated peptide or protein ester group under basic conditions in order to obtain an N-acylated peptide or an N-acylated protein.
    Type: Grant
    Filed: March 13, 2000
    Date of Patent: September 17, 2002
    Assignee: Novo Nordisk A/S
    Inventor: Louis Brammer Hansen
  • Selective acylation method
    Patent number: 5905140
    Abstract: A method of selectively acylating an insulin, an insulin analogue or a precursor thereof having a free .epsilon.-amino group of a Lys residue contained therein and at least one free .alpha.-amino group which method comprises reacting the .epsilon.-amino group with an activated amide in a polar solvent in the presence of a base.
    Type: Grant
    Filed: July 8, 1997
    Date of Patent: May 18, 1999
    Assignee: Novo Nordisk A/S, Novo Alle
    Inventor: Louis Brammer Hansen
  • Acid addition salts of 2, 3, 4, 5-tetrahydro-1H-3-benzazepine compounds
    Patent number: 5658899
    Abstract: The invention provides a series of crystalline salts of (S)-8-chloro-5-(5-bromo-2,3-dihydrobenzofuran-7-yl)-3-methyl-2,3,4,5-tetra hydro-1H-3-benzazepine-7-ol, their preparation and use as therapeutic agents.
    Type: Grant
    Filed: March 14, 1995
    Date of Patent: August 19, 1997
    Assignee: Novo Nordisk A/S
    Inventors: Louis Brammer Hansen, Rolf Emil Amsler, Scott Eugene McGraw