Patents by Inventor Louis Brogley

Louis Brogley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Hydroxypropyl amides for the treatment of Alzheimer's disease
    Patent number: 7262208
    Abstract: The present invention relates to compounds of formula (I): useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme that are useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of A beta peptide in a mammal. The compounds of the invention are useful in pharmaceutical compositions and methods of treatment to reduce A beta peptide formation.
    Type: Grant
    Filed: April 30, 2003
    Date of Patent: August 28, 2007
    Assignees: Elan Pharmaceuticals, Inc., Pharmacia & Upjohn Company
    Inventors: John A. Tucker, Brian A. Sherer, Ying Zi Xu, Louis Brogley, Shon R. Pulley, Jon S. Jacobs, James P. Beck, Varghese John
  • Sulfonylquinoxalone derivatives and related compounds as bradykinin antagonists
    Patent number: 7183281
    Abstract: Disclosed are sulfonylquinoxalone derivatives of the general formula: These compounds are useful as bradykinin antagonists.
    Type: Grant
    Filed: May 2, 2003
    Date of Patent: February 27, 2007
    Assignee: Elan Pharmaceuticals, Inc.
    Inventors: Francine S. Grant, Sarah Bartulis, Louis Brogley, Michael S. Dappen, Ramesh Kasar, Mohammed A. Khan, Martin Neitzel, Michael A. Pleiss, Eugene D. Thorsett, John Tucker, Michael Ye, Jon E. Hawkinson
  • Sulfonylquinoxalone derivatives and related compounds as bradykinin antagonists
    Publication number: 20060293332
    Abstract: Disclosed are sulfonylquinoxalone acetamide derivatives useful as bradykinin antagonists.
    Type: Application
    Filed: May 5, 2006
    Publication date: December 28, 2006
    Inventors: Francine Grant, Sarah Bartulis, Louis Brogley, Michael Dappen, Ramesh Kasar, Mohammed Khan, Martin Neitzel, Michael Pleiss, Eugene Thorsett, John Tucker, Michael Ye, Jon Hawkinson
  • Sulfonylquinoxalone derivatives as bradykinin antagonists
    Patent number: 7056937
    Abstract: Disclosed are 1-sulfonylquioxalone acetamides and derivatives thereof. The compounds are exemplified by compounds of the formula: Such compounds, derivatives and related compounds are useful as bradykinin antagonists.
    Type: Grant
    Filed: May 2, 2003
    Date of Patent: June 6, 2006
    Assignee: Elan Pharmaceuticals, Inc.
    Inventors: Francine S. Grant, Sarah Bartulis, Louis Brogley, Michael S. Dappen, Ramesh Kasar, Ryan Holcomb, Michael A. Pleiss, Eugene D. Thorsett, Michael Ye, Jon E. Hawkinson
  • Methods of treatment of amyloidosis using bi-cyclic aspartyl protease inhibitors
    Publication number: 20050239832
    Abstract: The invention relates to novel compounds and methods of treating diseases, disorders, and conditions associated with amyloidosis. Amyloidosis refers to a collection of diseases, disorders, and conditions associated with abnormal deposition of A-beta protein.
    Type: Application
    Filed: March 9, 2005
    Publication date: October 27, 2005
    Inventors: Varghese John, Michel Maillard, Lawrence Fang, John Tucker, Louis Brogley, Jose Aquino, Simeon Bowers, Gary Probst, Jay Tung
  • Substituted hydroxyethylamine aspartyl protease inhibitors
    Publication number: 20050239836
    Abstract: The invention relates to novel compounds and also to methods of treating at least one disease, disorder, or condition associated with amyloidosis using such compounds. Amyloidosis refers to a collection of diseases, disorders, and conditions associated with abnormal deposition of A-beta protein.
    Type: Application
    Filed: March 9, 2005
    Publication date: October 27, 2005
    Inventors: Varghese John, Michel Maillard, John Tucker, Jose Aquino, Barbara Jagodzinska, Louis Brogley, Jay Tung, Simeon Bowers, Darren Dressen, Gary Probst, Neerav Shah
  • Substituted hydroxyethylamine aspartyl protease inhibitors
    Publication number: 20050239790
    Abstract: The invention relates to novel compounds and also to methods of treating at least one disease, disorder, or condition associated with amyloidosis using such compounds. Amyloidosis refers to a collection of diseases, disorders, and conditions associated with abnormal deposition of A-beta protein.
    Type: Application
    Filed: March 9, 2005
    Publication date: October 27, 2005
    Inventors: Varghese John, Michel Maillard, John Tucker, Barbara Jagodzinska, Louis Brogley, Jay Tung, Neerav Shah, R. Neitz
  • Sulfonylquinoxalone acetamide derivatives as bradykinin antagonists
    Publication number: 20040147519
    Abstract: Disclosed are sulfonylquinoxalone acetamide derivatives useful as bradykinin antagonists.
    Type: Application
    Filed: May 2, 2003
    Publication date: July 29, 2004
    Inventors: Francine S. Grant, Sarah Bartulis, Louis Brogley, Michael S. Dappen, Ramesh Kasar, Ryan Holcomb, Michael A. Pleiss, Eugene D. Thorsett, Michael Ye, Jon E. Hawkinson
  • Sulfonylquinoxalone acetamide derivatives and related compounds as bradykinin antagonists
    Publication number: 20040147520
    Abstract: Disclosed are sulfonylquinoxalone acetamide derivatives useful as bradykinin antagonists.
    Type: Application
    Filed: May 2, 2003
    Publication date: July 29, 2004
    Inventors: Francine S. Grant, Sarah Bartulis, Louis Brogley, Michael S. Dappen, Ramesh Kasar, Mohammed A. Khan, Martin Neitzel, Michael A. Pleiss, Eugene D. Thorsett, John Tucker, Michael Ye, Jon E. Hawkinson
  • Hydroxypropyl amides for the treatment of Alzheimer's disease
    Publication number: 20040039034
    Abstract: The present invention relates to compounds of formula (I): 1
    Type: Application
    Filed: April 30, 2003
    Publication date: February 26, 2004
    Inventors: John A. Tucker, Brian A. Sherer, Ying Zi Xu, Louis Brogley, Shon R. Pulley, Jon S. Jacobs, James P. Beck, Varghese John
  • Peptidyl calcium channel blockers
    Patent number: 6423689
    Abstract: The present invention provides compounds that block calcium channels having the Formula I shown below. The present invention also provides methods of using the compounds of Formula I to treat stroke, cerebral ischemia, head trauma, or epilepsy and to pharmaceutical compositions that contain the compounds of Formula I.
    Type: Grant
    Filed: December 16, 1998
    Date of Patent: July 23, 2002
    Assignees: Warner-Lambert Company, Neurex Corporation
    Inventors: Richard John Booth, Louis Brogley, Wayne Livingston Cody, David Thomas Connor, Harriet Wall Hamilton, John Xiaoqiang He, Lain-Yen Hu, Leonard Joseph Lescosky, Thomas Charles Malone, Laszlo Nadasdi, Michael Francis Rafferty, Bruce David Roth, Diego F. Silva, Yuntao Song, Balazs G. Szoke, Laszlo Urge